Mechanism for Radical Cation Transport in Duplex DNA Oligonucleotides

2004 ◽  
Vol 126 (9) ◽  
pp. 2877-2884 ◽  
Author(s):  
Chu-Sheng Liu ◽  
Rigoberto Hernandez ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Cation Transport ◽  
Duplex Dna ◽  
Dna Oligonucleotides

Synthesis and Incorporation of a Cationic Pyridinium Nucleoside Mimic in Duplex DNA:  Effect on Long-Distance Radical Cation Transport

2006 ◽  
Vol 8 (23) ◽  
pp. 5255-5258 ◽  
Author(s):  
Frank O. Onyemauwa ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Cation Transport ◽  
Duplex Dna ◽  
Long Distance

Direct Observation of Guanine Radical Cation Deprotonation in Duplex DNA Using Pulse Radiolysis

2003 ◽  
Vol 125 (34) ◽  
pp. 10213-10218 ◽  
Author(s):  
Kazuo Kobayashi ◽  
Seiichi Tagawa
Keyword(s):  
Radical Cation ◽  
Direct Observation ◽  
Pulse Radiolysis ◽  
Duplex Dna

Radical Cation Transport and Reaction in Triplex DNA:  Long-Range Guanine Damage

1999 ◽  
Vol 121 (50) ◽  
pp. 11607-11614 ◽  
Author(s):  
Yongzhi Kan ◽  
Gary B. Schuster
Keyword(s):  
Long Range ◽  
Radical Cation ◽  
Cation Transport ◽  
Triplex Dna

Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA

2011 ◽  
Vol 89 (3) ◽  
pp. 326-330 ◽  
Author(s):  
Sriram Kanvah ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Dna Analysis ◽  
Duplex Dna ◽  
Charge Migration ◽  
Electron Hole ◽  
Dna Oligomers ◽  
Phosphodiester Backbone ◽  
Cation Migration ◽  
Covalently Linked ◽  
Positively Charged

A series of DNA oligomers were prepared that contain guanidinium linkages (positively charged) positioned selectively in place of and among the normal negatively charged phosphodiester backbone groups of duplex DNA. One-electron oxidation of these DNA oligomers by UV irradiation of a covalently linked anthraquinone group generates a radical cation (electron “hole”) that migrates by hopping through the DNA and is trapped at reactive sites, GG steps, to form mutated bases that are detected by strand cleavage after subsequent piperidine treatment of the irradiated DNA. Analysis of the strand cleavage pattern reveals that guanidinium substitution in these oligomers does not measurably affect the charge migration rate but it does inhibit reaction at nearby guanines.

Site selective generation of guanine radical cation in duplex DNA: modulation of the direction of hole transport

2000 ◽  
Vol 41 (51) ◽  
pp. 10041-10045 ◽  
Author(s):  
Kazuhiko Nakatani* ◽  
Chikara Dohno ◽  
Isao Saito
Keyword(s):  
Radical Cation ◽  
Hole Transport ◽  
Duplex Dna ◽  
Selective Generation ◽  
Site Selective

Simultaneous detection of duplex DNA oligonucleotides using a SERS-based micro-network gradient chip

Lab on a Chip ◽  
2012 ◽  
Vol 12 (24) ◽  
pp. 5160 ◽  
Author(s):  
Namhyun Choi ◽  
Kangsun Lee ◽  
Dong Woo Lim ◽  
Eun Kyu Lee ◽  
Soo-Ik Chang ◽  
...  
Keyword(s):  
Simultaneous Detection ◽  
Duplex Dna ◽  
Dna Oligonucleotides

Long-distance radical cation transport in DNA: horizontal charge hopping in a dimeric quadruplex

2006 ◽  
Vol 4 (21) ◽  
pp. 4015 ◽  
Author(s):  
Thabisile Ndlebe ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Cation Transport ◽  
Long Distance ◽  
Charge Hopping
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