Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA

2011 ◽  
Vol 89 (3) ◽  
pp. 326-330 ◽  
Author(s):  
Sriram Kanvah ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Dna Analysis ◽  
Duplex Dna ◽  
Charge Migration ◽  
Electron Hole ◽  
Dna Oligomers ◽  
Phosphodiester Backbone ◽  
Cation Migration ◽  
Covalently Linked ◽  
Positively Charged

A series of DNA oligomers were prepared that contain guanidinium linkages (positively charged) positioned selectively in place of and among the normal negatively charged phosphodiester backbone groups of duplex DNA. One-electron oxidation of these DNA oligomers by UV irradiation of a covalently linked anthraquinone group generates a radical cation (electron “hole”) that migrates by hopping through the DNA and is trapped at reactive sites, GG steps, to form mutated bases that are detected by strand cleavage after subsequent piperidine treatment of the irradiated DNA. Analysis of the strand cleavage pattern reveals that guanidinium substitution in these oligomers does not measurably affect the charge migration rate but it does inhibit reaction at nearby guanines.

Polaronic semiconductor behavior of long-range charge transfer in DNA oligomers in solution: controlling barriers to long-distance radical cation migration in DNA with thymine analogs

2006 ◽  
Vol 131 ◽  
pp. 357-365 ◽  
Author(s):  
Abraham Joy ◽  
Gozde Guler ◽  
Shahadat Ahmed ◽  
Larry W. McLaughlin ◽  
Gary B. Schuster
Keyword(s):  
Charge Transfer ◽  
Long Range ◽  
Radical Cation ◽  
Long Distance ◽  
Dna Oligomers ◽  
Cation Migration ◽  
Semiconductor Behavior ◽  
Charge Transfer In Dna

Base Sequence Effects in Radical Cation Migration in Duplex DNA:  Support for the Polaron-Like Hopping Model

2003 ◽  
Vol 125 (20) ◽  
pp. 6098-6102 ◽  
Author(s):  
Chu-Sheng Liu ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Base Sequence ◽  
Duplex Dna ◽  
Cation Migration ◽  
Sequence Effects ◽  
Hopping Model

Long-Distance Radical Cation Migration in Duplex DNA:  The Effect of Contiguous A·A and T·T Mismatches on Efficiency and Mechanism

2003 ◽  
Vol 125 (51) ◽  
pp. 15732-15733 ◽  
Author(s):  
Nathan W. Schlientz ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Duplex Dna ◽  
Long Distance ◽  
Cation Migration

scholarly journals Oligothymidylates covalently linked to an acridine derivative and with modified phosphodiester backbone: circular dichroism studies of their Interactions with complementary sequences

1989 ◽  
Vol 17 (5) ◽  
pp. 1823-1837 ◽  
Author(s):  
M. Durand ◽  
J.C Maurizot ◽  
U. Asseline ◽  
C. Barbier ◽  
N.T. Thuong ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Phosphodiester Backbone ◽  
Acridine Derivative ◽  
Complementary Sequences ◽  
Covalently Linked ◽  
Circular Dichroïsm

Positively Charged Surface Induces Discontinuous Transition for the High Order Structure in Duplex DNA

1995 ◽  
Vol 214 (3) ◽  
pp. 1040-1044 ◽  
Author(s):  
Y.S. Melnikova ◽  
N. Kumazawa ◽  
K. Yoshikawa
Keyword(s):  
High Order ◽  
Order Structure ◽  
Duplex Dna ◽  
Charged Surface ◽  
High Order Structure ◽  
Discontinuous Transition ◽  
Positively Charged

Direct Observation of Guanine Radical Cation Deprotonation in Duplex DNA Using Pulse Radiolysis

2003 ◽  
Vol 125 (34) ◽  
pp. 10213-10218 ◽  
Author(s):  
Kazuo Kobayashi ◽  
Seiichi Tagawa
Keyword(s):  
Radical Cation ◽  
Direct Observation ◽  
Pulse Radiolysis ◽  
Duplex Dna

RNase H1 Can Catalyze RNA/DNA Hybrid Formation and Cleavage with Stable Hairpin or Duplex DNA Oligomers†

Biochemistry ◽  
1998 ◽  
Vol 37 (15) ◽  
pp. 5154-5161 ◽  
Author(s):  
Jing Li ◽  
Roger M. Wartell
Keyword(s):  
Duplex Dna ◽  
Dna Oligomers ◽  
Hybrid Formation

ATOMISTIC SIMULATION OF DISSIPATIVE CHARGE CARRIER DYNAMICS FOR PHOTOCATALYSIS

2012 ◽  
Vol 1390 ◽  
Author(s):  
Talgat M. Inerbaev ◽  
Dmitri S. Kilin ◽  
James Hoefelmeyer
Keyword(s):  
Charge Transfer ◽  
High Surface ◽  
High Surface Area ◽  
Oxidation Catalysis ◽  
Electron Hole ◽  
Charge Carrier Dynamics ◽  
Electron Hole Pair ◽  
Charge Transfer Dynamics ◽  
Reduced Density ◽  
Positively Charged

ABSTRACTPhoto-excitation of high surface area semiconductor nanorods decorated with surface catalyst particles are investigated. DFT-based simulation is applied to the charge transfer dynamics at the interface of the supported nanocatalyst by modeling dynamics of photo-excitations. The modeling is performed by reduced density matrix method in the basis of Kohn-Sham orbitals. The energy of photo-excitation is dissipating due to interaction with lattice vibrations, treated through non-adiabatic coupling as the electron/hole pair relaxes to the conduction / valence band edges. The methodology is applied to TiO2 nanorod modeled as a periodic anatase (100) slab functionalized by minimalistic nano-clusters or doping. Simulations of these models demonstrate the formation of charge transfer state in both time and frequency domain. Computed charge dynamics leads to creation of positively charged areas on the nanorod surface that is an important prerequisite for oxidation catalysis. Our computation identifies optimal composition and morphology of nanocatalyst for such applications as water splitting for hydrogen production or solar cells.

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