Long-Distance Radical Cation Migration in Duplex DNA:  The Effect of Contiguous A·A and T·T Mismatches on Efficiency and Mechanism

2003 ◽  
Vol 125 (51) ◽  
pp. 15732-15733 ◽  
Author(s):  
Nathan W. Schlientz ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Duplex Dna ◽  
Long Distance ◽  
Cation Migration

Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA

2011 ◽  
Vol 89 (3) ◽  
pp. 326-330 ◽  
Author(s):  
Sriram Kanvah ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Dna Analysis ◽  
Duplex Dna ◽  
Charge Migration ◽  
Electron Hole ◽  
Dna Oligomers ◽  
Phosphodiester Backbone ◽  
Cation Migration ◽  
Covalently Linked ◽  
Positively Charged

A series of DNA oligomers were prepared that contain guanidinium linkages (positively charged) positioned selectively in place of and among the normal negatively charged phosphodiester backbone groups of duplex DNA. One-electron oxidation of these DNA oligomers by UV irradiation of a covalently linked anthraquinone group generates a radical cation (electron “hole”) that migrates by hopping through the DNA and is trapped at reactive sites, GG steps, to form mutated bases that are detected by strand cleavage after subsequent piperidine treatment of the irradiated DNA. Analysis of the strand cleavage pattern reveals that guanidinium substitution in these oligomers does not measurably affect the charge migration rate but it does inhibit reaction at nearby guanines.

Long-Distance Radical Cation Migration through A/T Base Pairs in DNA:  An Experimental Test of Theory

2001 ◽  
Vol 105 (45) ◽  
pp. 11057-11059 ◽  
Author(s):  
Valerie Sartor ◽  
Edna Boone ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Experimental Test ◽  
Base Pairs ◽  
Long Distance ◽  
Cation Migration

Synthesis and Incorporation of a Cationic Pyridinium Nucleoside Mimic in Duplex DNA:  Effect on Long-Distance Radical Cation Transport

2006 ◽  
Vol 8 (23) ◽  
pp. 5255-5258 ◽  
Author(s):  
Frank O. Onyemauwa ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Cation Transport ◽  
Duplex Dna ◽  
Long Distance

Long-Distance Radical Cation Migration in Z-Form DNA

2001 ◽  
Vol 123 (27) ◽  
pp. 6696-6697 ◽  
Author(s):  
Ibrahim M. Abdou ◽  
Valerie Sartor ◽  
Huachuan Cao ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Long Distance ◽  
Cation Migration

Polaronic semiconductor behavior of long-range charge transfer in DNA oligomers in solution: controlling barriers to long-distance radical cation migration in DNA with thymine analogs

2006 ◽  
Vol 131 ◽  
pp. 357-365 ◽  
Author(s):  
Abraham Joy ◽  
Gozde Guler ◽  
Shahadat Ahmed ◽  
Larry W. McLaughlin ◽  
Gary B. Schuster
Keyword(s):  
Charge Transfer ◽  
Long Range ◽  
Radical Cation ◽  
Long Distance ◽  
Dna Oligomers ◽  
Cation Migration ◽  
Semiconductor Behavior ◽  
Charge Transfer In Dna

Base Sequence Effects in Radical Cation Migration in Duplex DNA:  Support for the Polaron-Like Hopping Model

2003 ◽  
Vol 125 (20) ◽  
pp. 6098-6102 ◽  
Author(s):  
Chu-Sheng Liu ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Base Sequence ◽  
Duplex Dna ◽  
Cation Migration ◽  
Sequence Effects ◽  
Hopping Model

scholarly journals Effect of condensate formation on long-distance radical cation migration in DNA

2005 ◽  
Vol 102 (40) ◽  
pp. 14227-14231 ◽  
Author(s):  
P. Das ◽  
G. B. Schuster
Keyword(s):  
Radical Cation ◽  
Long Distance ◽  
Cation Migration ◽  
Condensate Formation
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