Gold Metal-Catalyzed Reactions of Isocyanides with Primary Amines and Oxygen:  Analogies with Reactions of Isocyanides in Transition Metal Complexes

2006 ◽  
Vol 128 (32) ◽  
pp. 10613-10620 ◽  
Author(s):  
Mihaela Lazar ◽  
Robert J. Angelici
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Primary Amines ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Gold Metal

Chemistry of Unsymmetrical C1-Substituted Oxabenzonorbornadienes

2021 ◽  
Vol 17 ◽  
Author(s):  
Austin Pounder ◽  
Angel Ho ◽  
Matthew Macleod ◽  
William Tam
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Substituent Effects ◽  
Face Selectivity ◽  
Transition Metal Catalyzed ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Synthetic Intermediate

: Oxabenzonorbornadiene (OBD) is a useful synthetic intermediate which can be readily activated by transition metal complexes with great face selectivity due to its dual-faced nature and intrinsic angle strain on the alkene. To date, the understanding of transition-metal catalyzed reactions of OBD itself has burgeoned; however, this has not been the case for unsymmetrical OBDs. Throughout the development of these reactions, the nature of C1-substituent has proven to have a profound effect on both the reactivity and selectivity of the outcome of the reaction. Upon substitution, different modes of reactivity arise, contributing to the possibility of multiple stereo-, regio-, and in extreme cases, constitutional isomers which can provide unique means of constructing a variety of synthetically useful cyclic frameworks. To maximize selectivity, an understanding of bridgehead substituent effects is crucial. To that end, this review outlines hitherto reported examples of bridgehead substituent effects on the chemistry of unsymmetrical C1-substituted OBDs.

Recent Advances in Transition Metal Catalyzed C-H Functionalization Reactions Involving Aza/Oxabicyclic Alkenes

Synthesis ◽  
2021 ◽  
Author(s):  
Masilamani Jeganmohan ◽  
Pinki Sihag
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Ring Opening ◽  
Bond Activation ◽  
Considerable Progress ◽  
Double Bonds ◽  
Facial Selectivity ◽  
Ring Opening Reactions ◽  
Metal Catalyzed

Bicyclic alkenes, including Oxa- and azabicyclic alkenes can be readily activated by using transition-metal complexes with facial selectivity, because of the intrinsic angle strain on carbon-carbon double bonds of these unsymmetrical bicyclic systems. During last decades considerable progress has been done in the area of ring-opening of bicyclic strained ring by employing the concept of C-H activation. This Review comprehensively compiles the various C-H bond activation assisted reactions of oxa- and azabicyclic alkenes, viz., ring-opening reactions, hydroarylation as well as annulation reactions.

Catalytic activation of nitrogen derivatives with transition-metal complexes

2006 ◽  
Vol 78 (2) ◽  
pp. 363-375 ◽  
Author(s):  
Hélène Lebel ◽  
Olivier Leogane ◽  
Kim Huard ◽  
Sylvain Lectard
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Curtius Rearrangement ◽  
Catalytic Activation ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
High Level

Studies regarding the transition-metal-catalyzed decomposition of nitrogen derivatives toward Curtius rearrangement and the formation of nitrenes which undergo C-H insertion and aziridination reactions are presented. These processes lead to the formation of C-N bond with a high level of selectivity and efficiency.

scholarly journals APPLICATION OF METAL COMPLEXES OF SCHIFF BASES AS AN ANTIMICROBIAL DRUG: A REVIEW OF RECENT WORKS

2017 ◽  
Vol 9 (3) ◽  
pp. 27 ◽  
Author(s):  
Kumble Divya ◽  
Geetha M. Pinto ◽  
Asha F Pinto
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Transition Metal Complexes ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Antimicrobial Activities ◽  
Primary Amines ◽  
Unusual Structure

Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities including antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, herbicidal, and anti-inflammatory activities. The biological activity of the transition metal complexes derived from the Schiff base ligands has been widely studied. This review summarizes the importance, Scope and antimicrobial activities of Schiff base metal complexes.

scholarly journals Bis-silylation of internal alkynes enabled by Ni(0) catalysis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yun Zhang ◽  
Xi-Chao Wang ◽  
Cheng-Wei Ju ◽  
Dongbing Zhao
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Catalytic System ◽  
Building Blocks ◽  
Potential Utility ◽  
Internal Alkynes ◽  
Silyl Groups ◽  
Metal Catalyzed ◽  
Wide Potential

Abstract1,2-Bis-silyl alkenes have exciting synthetic potential for programmable sequential synthesis via manipulation of the two vicinal silyl groups. Transition metal-catalyzed bis-silylation of alkynes with disilanes is the most straightforward strategy to access such useful building blocks. However, this process has some limitations: (1) symmetric disilanes are frequently employed in most of the reactions to assemble two identical silyl groups, which makes chemoselective differentiation for stepwise downstream transformations difficult; (2) the main catalysts are low-valent platinum group transition metal complexes, which are expensive; and (3) internal alkynes remain challenging substrates with low inherent reactivity. Thus, the development of abundant metal-catalyzed bis-silylation of internal alkynes with unsymmetrical disilanes is of significance. Herein, we solve most of the aforementioned limitations in bis-silylation of unsaturated bonds by developing a strongly coordinating disilane reagent and a Ni(0) catalytic system. Importantly, we sufficiently realize the stepwise recognition of the two silyl groups, making this synthetic protocol of wide potential utility.

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