scholarly journals Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

2014 ◽  
Vol 136 (52) ◽  
pp. 17987-17995 ◽  
Author(s):  
Yibing Wu ◽  
Belgin Canturk ◽  
Hyunil Jo ◽  
Chunlong Ma ◽  
Eleonora Gianti ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
Type Versus ◽  
Wild Type ◽  
Dual Inhibitors ◽  
M2 Proton Channel

scholarly journals Discovery of Novel Dual Inhibitors of the Wild-Type and the Most Prevalent Drug-Resistant Mutant, S31N, of the M2 Proton Channel from Influenza A Virus

2013 ◽  
Vol 56 (7) ◽  
pp. 2804-2812 ◽  
Author(s):  
Jizhou Wang ◽  
Chunlong Ma ◽  
Jun Wang ◽  
Hyunil Jo ◽  
Belgin Canturk ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Resistant Mutant ◽  
Proton Channel ◽  
Drug Resistant ◽  
Wild Type ◽  
Drug Resistant Mutant ◽  
Dual Inhibitors ◽  
M2 Proton Channel

scholarly journals Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

2018 ◽  
Vol 10 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Qing-Yan Guo ◽  
Long-Hua Zhang ◽  
Chao Zuo ◽  
Dong-Liang Huang ◽  
Zhipeng A. Wang ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Mirror Image ◽  
Proton Channel ◽  
Channel Activity ◽  
M2 Proton Channel

scholarly journals New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode

2015 ◽  
Vol 96 ◽  
pp. 318-329 ◽  
Author(s):  
Matias Rey-Carrizo ◽  
Sabrina Gazzarrini ◽  
Salomé Llabrés ◽  
Marta Frigolé-Vivas ◽  
Jordi Juárez-Jiménez ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Binding Mode ◽  
Wild Type ◽  
Dual Inhibitors

scholarly journals Asp44 Stabilizes the Trp41 Gate of the M2 Proton Channel of Influenza A Virus

Structure ◽  
2013 ◽  
Vol 21 (11) ◽  
pp. 2033-2041 ◽  
Author(s):  
Chunlong Ma ◽  
Giacomo Fiorin ◽  
Vincenzo Carnevale ◽  
Jun Wang ◽  
Robert A. Lamb ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel

Recent Advances in Computational Studies on Influenza A Virus M2 Proton Channel

2012 ◽  
Vol 12 (10) ◽  
pp. 971-978 ◽  
Author(s):  
Jing-Fang Wang ◽  
Kuo-Chen Chou
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
Computational Studies ◽  
Recent Advances ◽  
M2 Proton Channel

scholarly journals Pharmacological Relevant Amantadine Binding Site is in the Pore of Influenza a Virus M2 Proton Channel

2010 ◽  
Vol 98 (3) ◽  
pp. 539a
Author(s):  
Chunlong Ma ◽  
Yuki Ohigashi ◽  
Xianghong Jing ◽  
Robert A. Lamb ◽  
Lawrence H. Pinto
Keyword(s):  
Binding Site ◽  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel

Structural Comparison of the Wild-Type and Drug-Resistant Mutants of the Influenza A M2 Proton Channel by Molecular Dynamics Simulations

2013 ◽  
Vol 117 (20) ◽  
pp. 6042-6051 ◽  
Author(s):  
Ruo-Xu Gu ◽  
Limin Angela Liu ◽  
Yong-Hua Wang ◽  
Qin Xu ◽  
Dong-Qing Wei
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Influenza A ◽  
Proton Channel ◽  
Drug Resistant ◽  
Wild Type ◽  
Structural Comparison ◽  
Resistant Mutants ◽  
M2 Proton Channel ◽  
Dynamics Simulations

scholarly journals Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

2016 ◽  
Vol 59 (3) ◽  
pp. 1207-1216 ◽  
Author(s):  
Fang Li ◽  
Chunlong Ma ◽  
William F. DeGrado ◽  
Jun Wang
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
Drug Resistant ◽  
M2 Proton Channel

scholarly journals Structure and mechanism of the M2 proton channel of influenza A virus

Nature ◽  
2008 ◽  
Vol 451 (7178) ◽  
pp. 591-595 ◽  
Author(s):  
Jason R. Schnell ◽  
James J. Chou
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel
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