scholarly journals Discovery of Novel Dual Inhibitors of the Wild-Type and the Most Prevalent Drug-Resistant Mutant, S31N, of the M2 Proton Channel from Influenza A Virus

2013 ◽  
Vol 56 (7) ◽  
pp. 2804-2812 ◽  
Author(s):  
Jizhou Wang ◽  
Chunlong Ma ◽  
Jun Wang ◽  
Hyunil Jo ◽  
Belgin Canturk ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Resistant Mutant ◽  
Proton Channel ◽  
Drug Resistant ◽  
Wild Type ◽  
Drug Resistant Mutant ◽  
Dual Inhibitors ◽  
M2 Proton Channel

Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus

2016 ◽  
Vol 108 ◽  
pp. 605-615 ◽  
Author(s):  
Jianghong Dong ◽  
Shengwei Chen ◽  
Runfeng Li ◽  
Wei Cui ◽  
Haiming Jiang ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Resistant Mutant ◽  
Drug Resistant ◽  
Wild Type ◽  
Drug Resistant Mutant ◽  
Dual Inhibitors

scholarly journals Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

2014 ◽  
Vol 136 (52) ◽  
pp. 17987-17995 ◽  
Author(s):  
Yibing Wu ◽  
Belgin Canturk ◽  
Hyunil Jo ◽  
Chunlong Ma ◽  
Eleonora Gianti ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
Type Versus ◽  
Wild Type ◽  
Dual Inhibitors ◽  
M2 Proton Channel

Structural Comparison of the Wild-Type and Drug-Resistant Mutants of the Influenza A M2 Proton Channel by Molecular Dynamics Simulations

2013 ◽  
Vol 117 (20) ◽  
pp. 6042-6051 ◽  
Author(s):  
Ruo-Xu Gu ◽  
Limin Angela Liu ◽  
Yong-Hua Wang ◽  
Qin Xu ◽  
Dong-Qing Wei
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Influenza A ◽  
Proton Channel ◽  
Drug Resistant ◽  
Wild Type ◽  
Structural Comparison ◽  
Resistant Mutants ◽  
M2 Proton Channel ◽  
Dynamics Simulations

scholarly journals Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

2016 ◽  
Vol 59 (3) ◽  
pp. 1207-1216 ◽  
Author(s):  
Fang Li ◽  
Chunlong Ma ◽  
William F. DeGrado ◽  
Jun Wang
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
Drug Resistant ◽  
M2 Proton Channel

scholarly journals Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

2018 ◽  
Vol 10 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Qing-Yan Guo ◽  
Long-Hua Zhang ◽  
Chao Zuo ◽  
Dong-Liang Huang ◽  
Zhipeng A. Wang ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Mirror Image ◽  
Proton Channel ◽  
Channel Activity ◽  
M2 Proton Channel

scholarly journals Baloxavir Marboxil Treatment of Nude Mice Infected With Influenza A Virus

2019 ◽  
Vol 221 (10) ◽  
pp. 1699-1702 ◽  
Author(s):  
Maki Kiso ◽  
Seiya Yamayoshi ◽  
Jurika Murakami ◽  
Yoshihiro Kawaoka
Keyword(s):  
Nude Mice ◽  
Influenza A ◽  
Body Weight Loss ◽  
Resistant Mutant ◽  
Prolonged Treatment ◽  
Drug Resistant ◽  
Neuraminidase Inhibitors ◽  
Drug Resistant Mutant ◽  
Suboptimal Dose ◽  
Resistant Mutants

Abstract Background Immunocompromised patients infected with influenza virus require prolonged treatment with neuraminidase inhibitors, because these patients are not able to eradicate the virus from the respiratory tract, leading to the emergence of drug-resistant mutant viruses. Methods In this study, we examined the efficacy of baloxavir marboxil in nude mice that were immunologically deficient. Results Daily treatment with a suboptimal dose of baloxavir marboxil increased the survival time of the virus-infected nude mice but did not clear the virus from their respiratory organs, resulting in gradual body weight loss after termination of treatment. Conclusions Despite the prolonged baloxavir marboxil treatment, few resistant mutants were detected.

scholarly journals New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode

2015 ◽  
Vol 96 ◽  
pp. 318-329 ◽  
Author(s):  
Matias Rey-Carrizo ◽  
Sabrina Gazzarrini ◽  
Salomé Llabrés ◽  
Marta Frigolé-Vivas ◽  
Jordi Juárez-Jiménez ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Binding Mode ◽  
Wild Type ◽  
Dual Inhibitors
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