1-Oxo-2-oxa-1-phosphabicyclo[2.2.2]octane:  A New Mechanistic Probe for the Basic Hydrolysis of Phosphate Esters

1996 ◽  
Vol 118 (42) ◽  
pp. 10168-10174 ◽  
Author(s):  
Andrzej E. Wróblewski ◽  
John G. Verkade
Keyword(s):  
Phosphate Esters ◽  
Mechanistic Probe ◽  
Basic Hydrolysis ◽  
Hydrolysis Of

ChemInform Abstract: 1-Oxo-2-oxa-1-phosphabicyclo(2.2.2)octane: A New Mechanistic Probe for the Basic Hydrolysis of Phosphate Esters.

ChemInform ◽  
2010 ◽  
Vol 28 (6) ◽  
pp. no-no
Author(s):  
A. E. WROBLEWSKI ◽  
J. G. VERKADE
Keyword(s):  
Phosphate Esters ◽  
Mechanistic Probe ◽  
Basic Hydrolysis ◽  
Hydrolysis Of

Basic hydrolysis of carbamate to amine in aqueous ethanol

10.1039/sp734 ◽  
2014 ◽  
Author(s):  
John MacMillan
Keyword(s):  
Aqueous Ethanol ◽  
Basic Hydrolysis ◽  
Hydrolysis Of

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

Tunable fluorescent and antimicrobial properties of poly(vinyl amine) affected by the acidic or basic hydrolysis of poly(N‐vinylformamide)

2021 ◽  
pp. 51234
Author(s):  
S. Duygu Sütekin ◽  
Sahin Demirci ◽  
Saliha B. Kurt ◽  
Olgun Güven ◽  
Nurettin Sahiner
Keyword(s):  
Antimicrobial Properties ◽  
Basic Hydrolysis ◽  
Hydrolysis Of

ChemInform Abstract: THE UNUSUALLY MILD AND FACILE BASIC HYDROLYSIS OF N-NITROSO-2-(METHYLAMINO)ACETONITRILE

1977 ◽  
Vol 8 (9) ◽  
pp. no-no
Author(s):  
S. K. CHANG ◽  
G. W. HARRINGTON ◽  
H. S. VEALE ◽  
D. SWERN
Keyword(s):  
Basic Hydrolysis ◽  
Hydrolysis Of

The synthesis of norbornanes with functionalized carbon substituents at a bridgehead. 1-(3-Oxonorborn-1-yl)ethanone and 1-(3-oxonorborn-1-yl)-2-propanone

1992 ◽  
Vol 70 (5) ◽  
pp. 1492-1505 ◽  
Author(s):  
Peter Yates ◽  
Magdy Kaldas
Keyword(s):  
Acetic Acid ◽  
Carboxylic Acid ◽  
Hydrogen Bromide ◽  
Tertiary Alcohol ◽  
Ethyl Bromoacetate ◽  
Second Molar ◽  
Molar Equivalent ◽  
Acid Lactone ◽  
Basic Hydrolysis ◽  
Hydrolysis Of

Treatment of 2-norobornene-1-carboxylic acid (7) with one equivalent of methyllithium in ether followed by a second molar equivalent after dilution with tetrahydrofuran gave 1-(norborn-2-en-lyl)ethanone (10) and only a trace of the tertiary alcohol 11. Reaction of 7 with formic acid followed by hydrolysis gave a 4:3 mixture of exo-3- and exo-2-hydroxynorbornane-1-carboxylic acid (16 and 17), whereas oxymercuration–demercuration gave only the exo-3-hydroxy isomer 16. Oxidation of 16 and 17 gave 3- and 2-oxonorbornane-1-carboxylic acid (27 and 29), respectively. Oxymercuration–demercuration of 10 gave exclusively 1-(exo-3-hydroxynorborn-1-yl)ethanone (30), which was also prepared by treatment of 16 with methyllithium in analogous fashion to that used for the conversion of 7 to 10. Oxidation of 30 gave 1-(3-oxonorborn-1-yl)ethanone (1). Dehydrobromination of exo-2-bromonorbornane-1-acetic acid and dehydration of 2-hydroxy-norbornane-2-acetic acid derivatives gave 1-(norborn-2-ylidene) acetic acid derivatives to the exclusion of norborn-2-ene-1 -acetic acid derivatives. Treatment of exo-5-acetyloxy-2-norobornanone (52) with ethyl bromoacetate and zinc gave ethyl exo-5-acetyloxy-2-hydroxynorbornane-(exo- and endo-2-acetate (53 and 54). Reaction of 53 with hydrogen bromide gave initially ethyl endo-3-acetyloxy-exo-6-bromonorbornane-1-acetate (59), which was subsequently converted to a mixture of 59 and its exo-3-acetyloxy epimer 61. Catalytic hydrogenation of this mixture gave a mixture of ethyl endo- and exo-3-acetyloxynorbornane-1 -acetate (62 and 63). Basic hydrolysis of this gave a mixture of the corresponding hydroxy acids, 70 and 71; the former was slowly converted to the latter at pH 5. Oxidation of the mixture of 70 and 71 gave 3-oxonorbornane-1-acetic acid (72). Treatment of the mixture with methyllithium as for 16 gave a mixture of 1-(endo- and exo-3-hydroxynorborn-1-yl)-2-propanone (73 and 74), which was oxidized to 1-(3-oxo-norborn-1-yl)-2-propanone (2). Reaction of exo-2-hydroxynorbornane-1-acetic acid lactone (75) with methyllithium in ether gave (1-(exo-2-hydroxynorborn-1-yl)-2-propanone (76), which on oxidation gave the 2-oxo isomer 78 of 2.

ChemInform Abstract: Cationic Water-Soluble Calixarenes: New Host Molecules Which Catalyze Basic Hydrolysis of a Phosphate Ester

ChemInform ◽  
1990 ◽  
Vol 21 (4) ◽  
Author(s):  
S. SHINKAI ◽  
Y. SHIRAHAMA ◽  
T. TSUBAKI ◽  
O. MANABE
Keyword(s):  
Water Soluble ◽  
Phosphate Ester ◽  
New Host ◽  
Host Molecules ◽  
Basic Hydrolysis ◽  
Hydrolysis Of

Oligomeric stannoxanes

1968 ◽  
Vol 46 (14) ◽  
pp. 2409-2413 ◽  
Author(s):  
Shmuel Migdal ◽  
David Gertner ◽  
Albert Zilkha
Keyword(s):  
Dicarboxylic Acids ◽  
Molar Ratio ◽  
Sodium Salts ◽  
Interfacial Conditions ◽  
Organotin Polyesters ◽  
Basic Hydrolysis ◽  
Hydrolysis Of

The controlled basic hydrolysis of tetrabutyl-1,3-dichlorodistannoxane under interfacial conditions was found to lead to α,ω-dichlorooligostannoxanes, Cl(SnBu2O)nSnBu2Cl, n being controlled by the molar ratio of base to distannoxane. These oligostannoxanes were identical with those prepared by other methods. They were used in the preparation of oligostannoxane dicarboxylates and organotin polyesters, having stannoxane recurring units in their backbone, by reaction with the sodium salts of mono- or dicarboxylic acids under interfacial conditions.

Hydrolysis of phosphate esters and anhydrides: role of metal ions

1987 ◽  
Vol 79 (3) ◽  
pp. 293-319 ◽  
Author(s):  
G.P. Haight
Keyword(s):  
Metal Ions ◽  
Phosphate Esters ◽  
Hydrolysis Of

Perkin communications. Cationic water-soluble calixarenes: new host molecules which catalyse basic hydrolysis of a phosphate ester

1989 ◽  
pp. 1859 ◽  
Author(s):  
Seiji Shinkai ◽  
Yoshiharu Shirahama ◽  
Takayuki Tsubaki ◽  
Osamu Manabe
Keyword(s):  
Water Soluble ◽  
Phosphate Ester ◽  
New Host ◽  
Host Molecules ◽  
Basic Hydrolysis ◽  
Hydrolysis Of
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