Macrocyclization of Interferon–Poly(α-amino acid) Conjugates Significantly Improves the Tumor Retention, Penetration, and Antitumor Efficacy

2018 ◽  
Vol 140 (3) ◽  
pp. 1170-1178 ◽  
Author(s):  
Yingqin Hou ◽  
Yu Zhou ◽  
Hao Wang ◽  
Ruijue Wang ◽  
Jingsong Yuan ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antitumor Efficacy ◽  
Amino Acid Conjugates ◽  
Tumor Retention

Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies

2020 ◽  
Vol 17 (1) ◽  
pp. 71-84
Author(s):  
Riham M. Bokhtia ◽  
Siva S. Panda ◽  
Adel S. Girgis ◽  
Hitesh H. Honkanadavar ◽  
Tarek S. Ibrahim ◽  
...  
Keyword(s):  
Experimental Data ◽  
Antibacterial Activity ◽  
Amino Acid ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Antibacterial Properties ◽  
Computational Studies ◽  
Protecting Group ◽  
Amino Acid Conjugates ◽  
Molecular Modeling Studies

Background: Bacterial infections are considered as one of the major global health threats, so it is very essential to design and develop new antibacterial agents to overcome the drawbacks of existing antibacterial agents. Method: The aim of this work is to synthesize a series of new fluoroquinolone-3-carboxamide amino acid conjugates by molecular hybridization. We utilized benzotriazole chemistry to synthesize the desired hybrid conjugates. Result: All the conjugates were synthesized in good yields, characterized, evaluated for their antibacterial activity. The compounds were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Synthesized conjugates were tested for activity against medically relevant pathogens; Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27856) Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis (ATCC 19433). Conclusion: The observed antibacterial experimental data indicates the selectivity of our synthesized conjugates against E.Coli. The protecting group on amino acids decreases the antibacterial activity. The synthesized conjugates are non-toxic to the normal cell lines. The experimental data were supported by computational studies.

scholarly journals Nicotinamide riboside–amino acid conjugates that are stable to purine nucleoside phosphorylase

2020 ◽  
Vol 18 (15) ◽  
pp. 2877-2885
Author(s):  
Faisal Hayat ◽  
Marie E. Migaud
Keyword(s):  
Amino Acid ◽  
Acid Ester ◽  
Purine Nucleoside Phosphorylase ◽  
Amino Acid Ester ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
Amino Acid Conjugates ◽  
Nicotinamide Riboside

O5′ amino acid ester conjugates of nicotinamide riboside, generated via a reduced intermediate, are stable to purine nucleoside phosphorylase.

Synthesis and anti-phlogistic potency of some new non-proteinogenic amino acid conjugates of ?Diclofenac?

Amino Acids ◽  
1999 ◽  
Vol 16 (3-4) ◽  
pp. 425-440 ◽  
Author(s):  
M. H. Abo-Ghalia ◽  
A. M. Shalaby ◽  
W. I. El-Eraqi ◽  
H. M. Awad
Keyword(s):  
Amino Acid ◽  
Amino Acid Conjugates ◽  
Proteinogenic Amino Acid

Synthesis and evaluation of some amino acid conjugates of pirprofen

2013 ◽  
Vol 3 (3) ◽  
pp. 241-246 ◽  
Author(s):  
S.K. Sharma ◽  
C. Karthikeyan ◽  
N.S. Hari Narayana Moorthy ◽  
D.K. Jain ◽  
P. Trivedi
Keyword(s):  
Amino Acid ◽  
Amino Acid Conjugates

Pyranosyl Sugar Amino Acid Conjugates

2001 ◽  
pp. 493-534 ◽  
Author(s):  
Jacquelyn Gervay-Hague ◽  
Thomas Weathers Jr
Keyword(s):  
Amino Acid ◽  
Amino Acid Conjugates

scholarly journals Synthesis of Enantiomerically Pure (Purin-6-yl)phenylalanines and Their Nucleosides, a Novel Type of Purine-Amino Acid Conjugates.

ChemInform ◽  
2005 ◽  
Vol 36 (52) ◽  
Author(s):  
Petr Capek ◽  
Radek Pohl ◽  
Michal Hocek
Keyword(s):  
Amino Acid ◽  
Enantiomerically Pure ◽  
Amino Acid Conjugates

Testing of 2,4,5-T-amino acid conjugates for mutagenic activity in Salmonella typhimurium strains

1984 ◽  
Vol 136 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Kamal A. Rashid ◽  
John G. Babish ◽  
Ralph O. Mumma
Keyword(s):  
Amino Acid ◽  
Salmonella Typhimurium ◽  
Mutagenic Activity ◽  
Amino Acid Conjugates

Amino acid conjugates and further new derivatives of dihydroartemisinin

1997 ◽  
Vol 339 (1) ◽  
pp. 642-645 ◽  
Author(s):  
Tran Duc Quan ◽  
Tran Van Sung ◽  
Helmut Ripperger ◽  
Günter Adam
Keyword(s):  
Amino Acid ◽  
Amino Acid Conjugates ◽  
Derivatives Of
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