Application of Response Surface Methodology to the Study of Methyl Glucoside Polyester Synthesis Parameters in a Solvent-Free System

2000 ◽  
Vol 48 (4) ◽  
pp. 1124-1128 ◽  
Author(s):  
Chwen-Jen Shieh ◽  
Yu-Fu Lai
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Solvent Free ◽  
Methyl Glucoside ◽  
Free System ◽  
Synthesis Parameters ◽  
Solvent Free System

scholarly journals Optimisation and Characterisation of Lipase-Catalysed Synthesis of a Kojic Monooleate Ester in a Solvent-Free System by Response Surface Methodology

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144664 ◽  
Author(s):  
Khairulazhar Jumbri ◽  
Mohd Fahruddin Al-Haniff Rozy ◽  
Siti Efliza Ashari ◽  
Rosfarizan Mohamad ◽  
Mahiran Basri ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Solvent Free ◽  
Free System ◽  
Solvent Free System

scholarly journals Optimization of enzymatic synthesis of ethyl hexanoate in a solvent free system using response surface methodology (RSM)

Biocatalysis ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 14-26 ◽  
Author(s):  
Sarita D. Gawas ◽  
Nidya Lokanath ◽  
Virendra K. Rathod
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Solvent Free ◽  
Molar Ratio ◽  
Esterification Reaction ◽  
Enzymatic Esterification ◽  
Ethyl Hexanoate ◽  
Free System ◽  
Acid Ratio ◽  
Solvent Free System

Abstract The present paper demonstrates application of biocatalysis to the synthesis of ethyl hexanoate, i.e. pineapple flavour ester, in a solvent free system. In order to evaluate the effect of various process parameters on reaction conversion, response surface methodology (RSM) complemented by central composite design (CCD) was employed. A maximum conversion of 88.57% was obtained while changing one factor at a time, at optimum conditions of temperature (50 °C), enzyme dose (2%), molar ratio acid to alcohol (1:3), speed of agitation 250 rpm and reaction time of 120 min. Based on this RSM study, the optimum predicted conditions were: 1:3.39 alcohol to acid ratio, 2.35% enzyme loading and 48.83 oC, for a predicted conversion of 90.99%. The activation energy for the enzymatic esterification was determined and calculated to be 25.76 kJ/mol. The positive values of Gibbs-free energy (ΔG), enthalpy (ΔH) and negative value of entropy (ΔS) revealed that the esterification reaction was non-spontaneous and an endothermic reaction. The reaction seems to follow bi-substrate Ping Pong Bi Bi mechanism with inhibition by both substrates.

Lipase-catalyzed synthesis of butyl propionate in solvent-free system: Optimization by response surface methodology

2014 ◽  
Vol 45 (5) ◽  
pp. 2233-2237 ◽  
Author(s):  
Wei-Chen Dai ◽  
Shwu-Jer Chiu ◽  
Dao-Yi Huang ◽  
Horng-Yi Juan ◽  
Cheng-Yu Chen ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
System Optimization ◽  
Solvent Free ◽  
Free System ◽  
Solvent Free System
Sign in / Sign up

Export Citation Format

Share Document