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2022 ◽  
pp. 113706
Author(s):  
Nicole M. Gilbertson ◽  
Natalie Z.M. Eichner ◽  
Julian M. Gaitán ◽  
John M. Pirtle ◽  
Jennifer L. Kirby ◽  
...  

2021 ◽  
Vol 37 (6) ◽  
pp. 1366-1370
Author(s):  
Minto Supeno ◽  
Agung Pratama

Sorbitol has a low calorie value, this is due to the presence of a pair of O-H free electrons on the sorbitol molecule. The pair of free electrons can be removed by the Tunnel method (through the shadow of the sorbitol container). Sorbitol which has lost a pair of free electrons from the O-H group is called sorbitol switching. The instrument used to prove the release of a pair of free electrons in the O-H group is to use FTIR and clinical trials conducted on mice given sorbitol to prove the effectiveness between sorbitol and sorbitol switching. The results show that sorbitol switching is able to maintain the stability of blood sugar levels in the body of mice and can reduce blood sugar levels.


Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 33
Author(s):  
Enric Sánchez ◽  
Maria-Dolores Santos ◽  
Maitane Nuñez-Garcia ◽  
Marta Bueno ◽  
Ignacio Sajoux ◽  
...  

Weight loss after bariatric surgery decreases the earlier expansion of the adventitial vasa vasorum (VV), a biomarker of early atheromatous disease. However, no data are available regarding weight loss achieved by very low calorie ketogenic diets (VLCKD) on VV and lipid-based atherogenic indices. A randomized clinical trial was performed to examine changes in adventitial VV density in 20 patients with moderate obesity who underwent a 6-month very low calorie ketogenic diet (VLCKD, 600–800 kcal/day), and 10 participants with hypocaloric diet based on the Mediterranean Diet (MedDiet, estimated reduction of 500 kcal on the usual intake). Contrast-enhanced carotid ultrasound was used to assess the VV. Body composition analysis was also used. The atherogenic index of plasma (log (triglycerides to high-density lipoprotein cholesterol ratio)) and the triglyceride-glucose index were calculated. Serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured. The impact of weight on quality of life-lite (IWQOL-Lite) questionnaire was administered. Participants of intervention groups displayed a similar VV values. Significant improvements of BMI (−5.3 [−6.9 to −3.6] kg/m2, p < 0.001), total body fat (−7.0 [−10.7 to −3.3] %, p = 0.003), and IWQOL-Lite score (−41.4 [−75.2 to −7.6], p = 0.027) were observed in VLCKD group in comparison with MedDiet group. Although after a 6-months follow-up period VV density (mean, right and left sides) did not change significantly in any group, participants in the VLCKD exhibited a significantly decrease both in their atherogenic index of plasma and serum concentration of sICAM-1. A 6-month intervention with VLCKD do not impact in the density of the adventitial VV in subjects with moderate obesity, but induces significant changes in markers of endothelial dysfunction and CV risk.


Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4468
Author(s):  
Ivan Ožvald ◽  
Dragan Božičević ◽  
Lidija Duh ◽  
Ivana Vinković Vrček ◽  
Ivan Pavičić ◽  
...  

Although a very-low-calorie diet (VLCD) is considered safe and has demonstrated benefits among other types of diets, data are scarce concerning its effects on improving health and weight loss in severely obese patients. As part of the personalized weight loss program developed at the Duga Resa Special Hospital for Extended Treatment, Croatia, we evaluated anthropometric, biochemical, and permanent DNA damage parameters (assessed with the cytochalasin B-blocked micronucleus cytome assay—CBMN) in severely obese patients (BMI ≥ 35 kg m−2) after 3-weeks on a 567 kcal, hospital-controlled VLCD. This is the first study on the permanent genomic (in)stability in such VLCD patients. VLCDs caused significant decreases in weight (loss), parameters of the lipid profile, urea, insulin resistance, and reduced glutathione (GSH). Genomic instability parameters were lowered by half, reaching reference values usually found in the healthy population. A correlation was found between GSH decrease and reduced DNA damage. VLCDs revealed susceptible individuals with remaining higher DNA damage for further monitoring. In a highly heterogeneous group (class II and III in obesity, differences in weight, BMI, and other categories) consisting of 26 obese patients, the approach demonstrated its usefulness and benefits in health improvement, enabling an individual approach to further monitoring, diagnosis, treatment, and risk assessment based on changing anthropometric/biochemical VLCD parameters, and CBMN results.


2021 ◽  
Author(s):  
Michal Folwarczny

In the recent decade, marketing literature has acknowledged the advantages of applying an evolutionary lens to understand consumer behavior in different domains. Food choice context is one such domain, having implications for societal well-being, especially for public health and addressing environmental issues. In this thesis, I investigate how mechanisms that have emerged as adaptations to food scarcity—frequent throughout human history—affect modern consumers’ food preferences, potentially leading to maladaptive outcomes. In Paper I, we highlight that selection pressures adjusted humans to forage in ancestral, hostile environments when they were wandering between periods of food scarcity and food sufficiency. Consequently, consumers often fail to choose foods appropriate to their current needs in contemporary retail contexts. Rather than attempting to override these hardwired and evolutionarily outdated food preferences, we recommend policymakers leverage them in such a way that facilitates healthier food choices. A series of studies reported in Paper II show that exposing people to climate change-induced food scarcity distant in time and space shifts their current food preferences. Specifically, people exposed to such video content exhibit a stronger preference toward energy-dense (vs. low-calorie) foods than their peers exposed to a control video. In Paper III, we aimed to account for potential confounds stemming from the control video used in studies reported in Paper II. Additionally, we strived to conceptually replicate these earlier findings by exposing participants to subtle cues to food scarcity—a winter forest walk. Although not all studies yielded significant results at conventional levels, this empirical package—when taken together—corroborated the earlier findings. Despite that studies described in Papers II–III provided a shred of empirical evidence showing a potency of food scarcity cues in increasing preferences toward energy-dense (vs. low-calorie) products, it was still unclear what drove such a shift in food liking. Thus, in Paper IV, we have developed and psychometrically validated the Anticipated Food Scarcity Scale (AFSS), measuring the degree to which people perceive food resources as becoming less available in the future. Aside from being a candidate mechanism partially explaining findings reported in Papers II–III, anticipated food scarcity (AFS) is also related to some aspects of prosociality. Studies presented in this thesis suggest that when environmental cues to food scarcity are present, people show a stronger preference toward energy-dense (vs. low-calorie) foods than their peers unexposed to such cues. Policymakers should consider these results when designing climate change and other similar campaigns, as such communication often depicts food scarcity. Additional research may explore the possibility that exposure to food scarcity cues affects food choices. Considering that we found AFS correlated with certain prosocial attitudes, it is a new psychological construct that warrants future investigation through multidisciplinary research.


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