P1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting Enzyme

1994 ◽  
Vol 37 (5) ◽  
pp. 563-564 ◽  
Author(s):  
Roland E. Dolle ◽  
Denton Hoyer ◽  
C. V. C. Prasad ◽  
Stanley J. Schmidt ◽  
Carla T. Helaszek ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Time Dependent ◽  
Interleukin 1 Beta ◽  
Converting Enzyme ◽  
Methyl Ketones

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

Biochemistry ◽  
1994 ◽  
Vol 33 (13) ◽  
pp. 3934-3940 ◽  
Author(s):  
Nancy A. Thornberry ◽  
Erin P. Peterson ◽  
Justin J. Zhao ◽  
Andrew D. Howard ◽  
Patrick R. Griffin ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Converting Enzyme ◽  
Methyl Ketones

scholarly journals Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells.

1993 ◽  
Vol 268 (24) ◽  
pp. 18062-18069 ◽  
Author(s):  
D.K. Miller ◽  
J.M. Ayala ◽  
L.A. Egger ◽  
S.M. Raju ◽  
T.T. Yamin ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Converting Enzyme ◽  
Purification And Characterization ◽  
Monocytic Cells

scholarly journals Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1994 ◽  
Vol 269 (30) ◽  
pp. 19331-19337 ◽  
Author(s):  
T. Komiyama ◽  
C.A. Ray ◽  
D.J. Pickup ◽  
A.D. Howard ◽  
N.A. Thornberry ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Cowpox Virus ◽  
Interleukin 1 Beta ◽  
Converting Enzyme

Interleukin-1 beta modulation of norepinephrine release from rat myenteric nerves

1993 ◽  
Vol 264 (1) ◽  
pp. G30-G35 ◽  
Author(s):  
S. Hurst ◽  
S. M. Collins
Keyword(s):  
Myenteric Plexus ◽  
Longitudinal Muscle ◽  
Interleukin 1 ◽  
Electrical Field Stimulation ◽  
Time Dependent ◽  
Interleukin 1 Beta ◽  
Norepinephrine Release ◽  
Rat Intestine ◽  
Electrical Field ◽  
Methionine Uptake

We examined the ability of human recombinant interleukin-1 beta (hrIL-1 beta) to alter the release of [3H]norepinephrine ([3H]NE) by KCl or electrical field stimulation in longitudinal muscle-myenteric plexus of rat intestine. The cytokine had no immediate effect on either the basal or evoked release of [3H]NE. However, hrIL-1 beta caused a biphasic time-dependent suppression of evoked [3H]NE release that was delayed in onset. IL-1 beta also stimulated the cycloheximide-sensitive uptake of [35S] methionine uptake by the tissue. The initial suppression of [3H]NE release was observed after 30 min and could not be inhibited by cycloheximide. A delayed peak was observed after 120 min and was inhibited by cycloheximide. The effect of IL-1 beta was maximal at 10 ng/ml and could be prevented by a neutralizing anti-IL-1 beta antibody or by preincubating the tissue with an IL-1-receptor antagonist. These results indicate that IL-1 beta suppresses [3H]NE release from rat myenteric plexus by two mechanisms, one of which is independent of protein synthesis and the other of which is mediated by endogenous IL-1.

scholarly journals Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 ◽  
Vol 93 (5) ◽  
pp. 2234-2238 ◽  
Author(s):  
C. Kayalar ◽  
T. Ord ◽  
M. P. Testa ◽  
L. T. Zhong ◽  
D. E. Bredesen
Keyword(s):  
Interleukin 1 ◽  
Dnase I ◽  
Interleukin 1 Beta ◽  
Converting Enzyme
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