Structure-activity correlations for the central nervous system depressant 2-imidazolidinones

1970 ◽  
Vol 13 (4) ◽  
pp. 623-626 ◽  
Author(s):  
Eric J. Lien ◽  
Mehdi. Hussain ◽  
Michael P. Golden
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Structure Activity ◽  
Central Nervous System Depressant ◽  
The Central Nervous System

PENENTUAN NILAI PARAMETER LIPOFILITAS SENYAWA 4-KLOROBENZOILTIOUREA DAN UJI POTENSIASI TERHADAP TIOPENTAL PADA MENCIT PUTIH (Mus musculus)

2019 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Dini Kesuma
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Electronic Properties ◽  
Mus Musculus ◽  
Log P ◽  
P Value ◽  
Lead Compounds ◽  
Significant Difference ◽  
Central Nervous System Depressant ◽  
The Central Nervous System

Synthesis of the 4-chlorobenzoylthiourea compound was carried out by acylating thiourea with 4-chlorobenzoyl chloride. The 4-chlorobenzoylthiourea compound  will increase the lipophilic and the electronic properties other than the lead compounds of benzoylthiourea in order to, by expectation, raise the central nervous system depressant as well. The lipophilic would affect the ability of the compounds in penetrating biological membranes, which is highly dependent on the solubility of the drug within lipid/water. Log P is the most common method used in determining the parameter value. This experiment was to mix two dissolvents (octanol and water) which are immissible. The both levels of the compounds were carefully observed by a spectrophotometer UV-Vis. From the test, the result of log P value of the 4-chlorobenzoylthiourea compound was 2.32, while the theoretical log P value of the compounds, by using the π Hansch-Fujita method is 1.62 and the f Rekker-Mannhold method is 2.225. Consequently, the result of the test shows that there is a significant difference between the progress experiment and both theoretical log P methods. Moreover, in the test of the central nervous system depressant through the potentiation test to thiopental using mice indicates that the 4-chlorobenzoylthiourea compound have potentiation effects to thiopental compared to the lead compounds of benzoylthiourea.

Synthesis of 2-exo- and 2-endo-mecamylamine analogs. Structure-activity relationships for nicotinic antagonism in the central nervous system

1991 ◽  
Vol 34 (3) ◽  
pp. 1003-1010 ◽  
Author(s):  
John A. Suchocki ◽  
Everette L. May ◽  
Thomas J. Martin ◽  
Clifford George ◽  
Billy R. Martin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
The Central Nervous System

scholarly journals Behavioral analyses of the central nervous system depressant activity of 2-amino-4-phenylthiazole upon fishes.

1974 ◽  
Vol 40 (4) ◽  
pp. 325-337 ◽  
Author(s):  
Takahiko KIKUCHI ◽  
Yasuharu SEKIZAWA ◽  
Yayoi IKEDA ◽  
Hisao OZAKI
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Depressant ◽  
The Central Nervous System

scholarly journals Evaluation of central nervous system depressant activity of Cleome rutidosperma

2012 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Anindya Bose ◽  
Anuradha Khuntia ◽  
Jayanta Kumar Gupta ◽  
Sudam Si
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ethanol Extract ◽  
Traditional Use ◽  
Cns Depressant ◽  
Aerial Parts ◽  
Central Nervous System Depressant ◽  
The Central Nervous System ◽  
Cns Depressant Activity ◽  
Cleome Rutidosperma

The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

scholarly journals Preliminary study on the central nervous system depressant effect of Picrorhiza kurrooa Royle. (Scrophulariaceae) in mice models

2008 ◽  
Vol 8 (4) ◽  
pp. 448-451 ◽  
Author(s):  
Tasmina Rahman ◽  
Khandaker Ashfaqur Rahman ◽  
Sultana Rajia ◽  
Mahiuddin Alamgir ◽  
Mahmud Tareq Hassan Khan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Depressant Effect ◽  
Picrorhiza Kurrooa ◽  
Central Nervous System Depressant ◽  
The Central Nervous System ◽  
Preliminary Study
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