Thyromimetics. VI. The Synthesis and Biological Screening of 3,5-Diiodothyroacetic and -propionic Acid Analogs

:Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines.

Download Full-text

Excess molar volumes of binary mixtures of acetic acid and propionic acid with some members of homologous series of alkanes

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19910736 ◽

1991 ◽

Vol 56 (4) ◽

pp. 736-744 ◽

Cited By ~ 11

Author(s):

Ondřej Drábek ◽

Ivan Cibulka

Keyword(s):

Acetic Acid ◽

Propionic Acid ◽

Alkyl Chain ◽

Excess Molar Volumes ◽

Liquid Mixtures ◽

Entire Concentration Range ◽

Molar Volumes ◽

Binary Liquid ◽

Alkane Molecule ◽

Increasing Temperature

Excess molar volumes of binary liquid mixtures of (acetic or propionic acid = hexane) at 25 and 35°C, and (acetic or propionic acid + heptane or octane) and (acetic acid + dodecane) at 25°C, measured with a tilting dilution dilatometer, are reported. The excess volumes are positive over the entire concentration range for all mixtures and increase with increasing length of an alkane molecule, decrease with increasing of the alkyl chain in a molecule of carboxylic acid, and increase with increasing temperature.

Download Full-text

Vapour-liquid equilibrium in the ternary system cyclohexane-acetic acid-propionic acid

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19892840 ◽

1989 ◽

Vol 54 (11) ◽

pp. 2840-2847 ◽

Cited By ~ 1

Author(s):

Ivona Malijevská ◽

Alena Maštalková ◽

Marie Sýsová

Keyword(s):

Acetic Acid ◽

Ternary System ◽

Propionic Acid ◽

Activity Coefficients ◽

Error Propagation ◽

Analytical Techniques ◽

Liquid Equilibrium ◽

Consistency Test ◽

Propagation Law ◽

Equilibrium Data

Isobaric equilibrium data (P = 101.3 kPa) for the system cyclohexane-acetic acid-propionic acid have been measured by two different analytical techniques. Activity coefficients calculated by simultaneous solving of equations for the chemical and phase equilibria were subjected to a consistency test based on inaccuracies determined from the error propagation law, and were correlated by Wilson’s equation. The activity coefficients measured were compared with those calculated from binary vapour-liquid equilibrium data and with values predicted by the UNIFAC method.

Download Full-text

XXI.—The Synthesis of Some Methyl- and Dimethylfluoranthenes

Proceedings of the Royal Society of Edinburgh Section A Mathematical and Physical Sciences ◽

10.1017/s0080454100008773 ◽

1972 ◽

Vol 69 (4) ◽

pp. 281-286

Author(s):

H. F. Andrew ◽

Neil Campbell ◽

E. M. Swan ◽

N. H. Wilson

Keyword(s):

Benzene Ring ◽

Propionic Acid ◽

Hydrofluoric Acid ◽

Phenyl Ring ◽

Ring Closure ◽

Methyl Group ◽

Image Position

3-Methylfluorene-9-propionic acid (1) with hydrofluoric acid undergoes ring-closure on the substituted ring to give 1,2,3,10b-tetrahydro-5-methylfluoranthen-3-one (II).Wolff-Kishner reduction of the ketone yielded l,2,3,10b-tetrahydro-5-methylfluoranthene which on dehydrogenation gave 2-methylfluoranthene (III, R=H) identical with a sample prepared according to the method of Tucker (1952) and differing from 8-methylfluoranthene. This proved that ring-closure of (I) had occurred as expected on the methyl-bearing benzene ring. In this instance ring-closure occurs in the position meta to the methyl group and is reminiscent of the similar ring-closure of 2-phenyl-2-p-tolylpropionic acid to give 6-methyl-3-phenylindanone (Pfeiffer and Roos 1941). It thus provided a further example of the limitations of von Braun's statement that Friedel-Crafts ring-closure occurs much less readily at the position meta to a methyl group than on a phenyl ring (von Braun, Manz and Reinsch 1928).

Download Full-text