Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogs

1984 ◽  
Vol 27 (11) ◽  
pp. 1486-1492 ◽  
Author(s):  
Morris J. Robins ◽  
Peter W. Hatfield ◽  
Jan Balzarini ◽  
Erik De Clercq
Keyword(s):  
Nucleic Acid ◽  
Biological Activities ◽  
Nucleoside Analogs ◽  
Acyclic Nucleoside ◽  
Related Compounds

Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides

1983 ◽  
Vol 26 (5) ◽  
pp. 661-666 ◽  
Author(s):  
Erik De Clercq ◽  
Johan Descamps ◽  
Jan Balzarini ◽  
Jerzy Giziewicz ◽  
Philip J. Barr ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Biological Activities ◽  
Related Compounds

Nucleic acid related compounds. 37. Convenient and high-yield syntheses of N-[(2-hydroxyethoxy)methyl] heterocycles as "acyclic nucleoside" analogues

1982 ◽  
Vol 60 (5) ◽  
pp. 547-553 ◽  
Author(s):  
Morris J. Robins ◽  
Peter W. Hatfield
Keyword(s):  
Nucleic Acid ◽  
Methyl Bromide ◽  
Antiviral Agent ◽  
Nucleoside Analogues ◽  
High Yield ◽  
Purine Derivatives ◽  
Acetyl Bromide ◽  
Acyclic Nucleoside Analogues ◽  
Acyclic Nucleoside ◽  
Related Compounds

Treatment of 1,3-dioxolane with acetyl bromide gave (2-acetoxyethoxy)methyl bromide (2a) in 88% yield. A number of pyrimidines and three chloropurines were trimethylsilylated and coupled with 2a. The respective N-1 and N-9 alkylated products (obtained in 79–89% yields) were deacetylated to give N-[(2-hydroxyethoxy)methyl] heterocycles. The 6-amino or 6-chloro substituent of the 2-amino-6-substituted-purine derivatives was hydrolyzed smoothly with adenosine deaminase to give 9-[(2-hydroxyethoxy)methyl]guanine (acycloguanosine), the potent antiviral agent.

ChemInform Abstract: NUCLEIC ACID RELATED COMPOUNDS. 40. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 5-ALKYNYLURACIL NUCLEOSIDES

1983 ◽  
Vol 14 (38) ◽  
Author(s):  
E. DE CLERCQ ◽  
J. DESCAMPS ◽  
J. BALZARINI ◽  
J. GIZIEWICZ ◽  
P. J. BARR ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Biological Activities ◽  
Related Compounds

Biotransformation of Coumarins by Filamentous Fungi: An Alternative Way for Achievement of Bioactive Analogs

2019 ◽  
Vol 16 (6) ◽  
pp. 568-577 ◽  
Author(s):  
Jainara Santos do Nascimento ◽  
João Carlos Silva Conceição ◽  
Eliane de Oliveira Silva
Keyword(s):  
Filamentous Fungi ◽  
Chemical Reactions ◽  
Biological Activities ◽  
Chemical Transformations ◽  
Chemical Structures ◽  
Pattern Structures ◽  
Pharmacological Interest ◽  
Aspergillus Sp ◽  
The Impact ◽  
Related Compounds

Coumarins are natural 1,2-benzopyrones, present in remarkable amounts as secondary metabolites in edible and medicinal plants. The low yield in the coumarins isolation from natural sources, along with the difficulties faced by the total synthesis, make them attractive for biotechnological studies. The current literature contains several reports on the biotransformation of coumarins by fungi, which can generate chemical analogs with high selectivity, using mild and eco-friendly conditions. Prompted by the enormous pharmacological interest in the coumarin-related compounds, their alimentary and chemical applications, this review covers the biotransformation of coumarins by filamentous fungi. The chemical structures of the analogs were presented and compared with those from the pattern structures. The main chemical reactions catalyzed the insertion of functional groups, and the impact on the biological activities caused by the chemical transformations were discussed. Several chemical reactions can be catalyzed by filamentous fungi in the coumarin scores, mainly lactone ring opening, C3-C4 reduction and hydroxylation. Chunninghamella sp. and Aspergillus sp. are the most common fungi used in these transformations. Concerning the substrates, the biotransformation of pyranocoumarins is a rarer process. Sometimes, the bioactivities were improved by the chemical modifications and coincidences with the mammalian metabolism were pointed out.

scholarly journals Myeloperoxidase Catalyzed Bromination of Nucleic Acid Bases and Related Compounds

1989 ◽  
Vol 62 (11) ◽  
pp. 3750-3751 ◽  
Author(s):  
Toshio Itahara ◽  
Naoko Ide
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Bases ◽  
Related Compounds

scholarly journals GraphBind: protein structural context embedded rules learned by hierarchical graph neural networks for recognizing nucleic-acid-binding residues

2021 ◽  
Author(s):  
Ying Xia ◽  
Chun-Qiu Xia ◽  
Xiaoyong Pan ◽  
Hong-Bin Shen
Keyword(s):  
Neural Networks ◽  
Nucleic Acid ◽  
Biological Activities ◽  
New Drugs ◽  
Superior Performance ◽  
Nucleic Acid Binding ◽  
Hierarchical Graph ◽  
Binding Residue ◽  
Binding Residues ◽  
Graph Neural Networks

Abstract Knowledge of the interactions between proteins and nucleic acids is the basis of understanding various biological activities and designing new drugs. How to accurately identify the nucleic-acid-binding residues remains a challenging task. In this paper, we propose an accurate predictor, GraphBind, for identifying nucleic-acid-binding residues on proteins based on an end-to-end graph neural network. Considering that binding sites often behave in highly conservative patterns on local tertiary structures, we first construct graphs based on the structural contexts of target residues and their spatial neighborhood. Then, hierarchical graph neural networks (HGNNs) are used to embed the latent local patterns of structural and bio-physicochemical characteristics for binding residue recognition. We comprehensively evaluate GraphBind on DNA/RNA benchmark datasets. The results demonstrate the superior performance of GraphBind than state-of-the-art methods. Moreover, GraphBind is extended to other ligand-binding residue prediction to verify its generalization capability. Web server of GraphBind is freely available at http://www.csbio.sjtu.edu.cn/bioinf/GraphBind/.

scholarly journals THE ASSIMILATION OF NUCLEIC ACID DERIVATIVES AND RELATED COMPOUNDS BY YEASTS

1951 ◽  
Vol 189 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Frederick J. Di Carlo ◽  
Alfred S. Schultz ◽  
Doris K. McManus
Keyword(s):  
Nucleic Acid ◽  
Related Compounds

Acyclic nucleoside analogs: synthesis of open-ring riboside or deoxyriboside analogs lacking C(3') or the C(3')-C(4') bond

1979 ◽  
Vol 44 (21) ◽  
pp. 3733-3734 ◽  
Author(s):  
Jerry D. Bryant ◽  
Gene E. Keyser ◽  
Jorge R. Barrio
Keyword(s):  
Nucleoside Analogs ◽  
Open Ring ◽  
Acyclic Nucleoside
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