Design, Synthesis, and Biological Activities of ClassicalN-{4-[2-(2-Amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-l-glutamic Acid and Its 6-Methyl Derivative as Potential Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase and as Potential Antitumor Agents1

2003 ◽  
Vol 46 (4) ◽  
pp. 591-600 ◽  
Author(s):  
Aleem Gangjee ◽  
Jianming Yu ◽  
Roy L. Kisliuk ◽  
William H. Haile ◽  
Giulia Sobrero ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Biological Activities ◽  
Methyl Derivative ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Potential Antitumor

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

2000 ◽  
Vol 43 (21) ◽  
pp. 3837-3851 ◽  
Author(s):  
Aleem Gangjee ◽  
Jianming Yu ◽  
John J. McGuire ◽  
Vivian Cody ◽  
Nikolai Galitsky ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Dual Inhibitor ◽  
Design Synthesis ◽  
X Ray

Pteridine–sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity

2010 ◽  
Vol 18 (14) ◽  
pp. 5081-5089 ◽  
Author(s):  
Sérgio M. Marques ◽  
Éva A. Enyedy ◽  
Claudiu T. Supuran ◽  
Natalia I. Krupenko ◽  
Sergey A. Krupenko ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Dihydrofolate Reductase ◽  
Carbonic Anhydrases ◽  
Dual Inhibitors ◽  
Potential Antitumor
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