Synthesis ofN-{4-[(2,4-Diamino-5-methyl-4,7-dihydro-3H- pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-l-glutamic Acid andN-{4-[(2-Amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin- 6-yl)thio]benzoyl}-l-glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase and as Potential Antitumor Agents

2005 ◽  
Vol 48 (23) ◽  
pp. 7215-7222 ◽  
Author(s):  
Aleem Gangjee ◽  
Xin Lin ◽  
Roy L. Kisliuk ◽  
John J. McGuire
Keyword(s):  
Glutamic Acid ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Antitumor Agents ◽  
Dual Inhibitors ◽  
Potential Antitumor

Pteridine–sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity

2010 ◽  
Vol 18 (14) ◽  
pp. 5081-5089 ◽  
Author(s):  
Sérgio M. Marques ◽  
Éva A. Enyedy ◽  
Claudiu T. Supuran ◽  
Natalia I. Krupenko ◽  
Sergey A. Krupenko ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Dihydrofolate Reductase ◽  
Carbonic Anhydrases ◽  
Dual Inhibitors ◽  
Potential Antitumor

ChemInform Abstract: Design and Synthesis of Cyclopenta[g]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents.

ChemInform ◽  
2010 ◽  
Vol 31 (35) ◽  
pp. no-no
Author(s):  
Vassilios Bavetsias ◽  
Jonathan H. Marriott ◽  
Camille Melin ◽  
Rosemary Kimbell ◽  
Zbigniew S. Matusiak ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
Antitumor Agents ◽  
Design And Synthesis ◽  
Potential Antitumor
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