Synthesis and Anticancer Activity of Simplified Indenoisoquinoline Topoisomerase I Inhibitors Lacking Substituents on the Aromatic Rings

2004 ◽  
Vol 47 (23) ◽  
pp. 5651-5661 ◽  
Author(s):  
Muthukaman Nagarajan ◽  
Andrew Morrell ◽  
Brian C. Fort ◽  
Marintha Rae Meckley ◽  
Smitha Antony ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Topoisomerase I ◽  
Aromatic Rings ◽  
Topoisomerase I Inhibitors

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

2021 ◽  
Vol 215 ◽  
pp. 113261
Author(s):  
Mostafa M. Elbadawi ◽  
Wagdy M. Eldehna ◽  
Wenjie Wang ◽  
Keli K. Agama ◽  
Yves Pommier ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Topoisomerase I ◽  
New Class ◽  
Topoisomerase I Inhibitors

Synthesis of New Dihydroindeno[1,2-c]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal Model

2002 ◽  
Vol 45 (1) ◽  
pp. 242-249 ◽  
Author(s):  
Muthusamy Jayaraman ◽  
Brian M. Fox ◽  
Melinda Hollingshead ◽  
Glenda Kohlhagen ◽  
Yves Pommier ◽  
...  
Keyword(s):  
Animal Model ◽  
Anticancer Activity ◽  
Hollow Fiber ◽  
Topoisomerase I ◽  
Topoisomerase I Inhibitors

Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

2015 ◽  
Vol 14 (23) ◽  
pp. 2722-2728 ◽  
Author(s):  
Concepcion Alonso ◽  
Maria Fuertes ◽  
Maria Gonzalez ◽  
Alicia Rodriguez-Gascon ◽  
Gloria Rubiales ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Biological Evaluation ◽  
Antiproliferative Agents ◽  
Topoisomerase I Inhibitors ◽  
New Family ◽  
Synthesis And Biological Evaluation

Investigation of Isoindolo[2,1-a]quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods

2017 ◽  
Vol 13 (3) ◽  
Author(s):  
Balazs Balogh ◽  
Anna Carbone ◽  
Virginia Spanò ◽  
Alessandra Montalbano ◽  
Paola Barraja ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Topoisomerase I ◽  
Modeling Methods ◽  
Topoisomerase I Inhibitors

Radiation lethality enhancement with 9-aminocamptothecin: Comparison to other topoisomerase I inhibitors

1996 ◽  
Vol 36 (2) ◽  
pp. 369-376 ◽  
Author(s):  
John P. Lamond ◽  
Meizhi Wang ◽  
Timothy J. Kinsella ◽  
David A. Boothman
Keyword(s):  
Topoisomerase I ◽  
Topoisomerase I Inhibitors
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