Synthesis and Structure−Activity Relationship of a Novel Series of Aminoalkylindoles with Potential for Imaging the Neuronal Cannabinoid Receptor by Positron Emission Tomography

2005 ◽  
Vol 48 (18) ◽  
pp. 5813-5822 ◽  
Author(s):  
Peter G. Willis ◽  
Olga A. Pavlova ◽  
Svetlana I. Chefer ◽  
D. Bruce Vaupel ◽  
Alexey G. Mukhin ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Cannabinoid Receptor ◽  
Structure Activity Relationship ◽  
Emission Tomography ◽  
Activity Relationship ◽  
Structure Activity ◽  
Positron Emission ◽  
Relationship Of

Synthesis and structure–activity relationship of novel diarylpyrazole imide analogues as CB1 cannabinoid receptor ligands

2009 ◽  
Vol 17 (8) ◽  
pp. 3080-3092 ◽  
Author(s):  
Kwang-Seop Song ◽  
Min Ju Kim ◽  
Hee Jeong Seo ◽  
Sung-Han Lee ◽  
Myung Eun Jung ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligands ◽  
Cb1 Cannabinoid Receptor ◽  
Structure Activity ◽  
Relationship Of

scholarly journals The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation

2016 ◽  
Vol 8 ◽  
pp. PMC.S32171 ◽  
Author(s):  
Eric W. Bow ◽  
John M. Rimoldi
Keyword(s):  
Cannabis Sativa ◽  
Cannabinoid Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Binding Modes ◽  
Structural Elements ◽  
Structure Activity ◽  
Simple Class ◽  
Initial Discovery ◽  
Relationship Of

The cannabinoids are members of a deceptively simple class of terpenophenolic secondary metabolites isolated from Cannabis sativa highlighted by (-)-Δ 9 -tetrahydrocannabinol (THC), eliciting distinct pharmacological effects mediated largely by cannabinoid receptor (CB1 or CB2) signaling. Since the initial discovery of THC and related cannabinoids, synthetic and semisynthetic classical cannabinoid analogs have been evaluated to help define receptor binding modes and structure–CB1/CB2 functional activity relationships. This perspective will examine the classical cannabinoids, with particular emphasis on the structure–activity relationship of five regions: C3 side chain, phenolic hydroxyl, aromatic A-ring, pyran B-ring, and cyclohexenyl C-ring. Cumulative structure–activity relationship studies to date have helped define the critical structural elements required for potency and selectivity toward CB1 and CB2 and, more importantly, ushered the discovery and development of contemporary nonclassical cannabinoid modulators with enhanced physicochemical and pharmacological profiles.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Structure Activity Relationship of Kahalalide F and its Analogs Against Fusarium Spp

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
N Kasanah ◽  
AG Shilabin ◽  
DE Wedge ◽  
MT Hamann
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Fusarium Spp ◽  
Structure Activity ◽  
Kahalalide F ◽  
Relationship Of
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