Dopamine/Serotonin Receptor Ligands. 121:  SAR Studies on Hexahydro-dibenz[d,g]azecines Lead to 4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the First Picomolar D5-Selective Dopamine-Receptor Antagonist

Patrick Mohr; Michael Decker; Christoph Enzensperger; Jochen Lehmann

doi:10.1021/jm051237e

Dopamine/Serotonin Receptor Ligands. 121: SAR Studies on Hexahydro-dibenz[d,g]azecines Lead to 4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the First Picomolar D5-Selective Dopamine-Receptor Antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm051237e ◽

2006 ◽

Vol 49 (6) ◽

pp. 2110-2116 ◽

Cited By ~ 27

Author(s):

Patrick Mohr ◽

Michael Decker ◽

Christoph Enzensperger ◽

Jochen Lehmann

Keyword(s):

Receptor Antagonist ◽

Dopamine Receptor ◽

Serotonin Receptor ◽

Receptor Ligands ◽

Dopamine Receptor Antagonist ◽

Sar Studies ◽

Selective Dopamine

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Dopamine/Serotonin Receptor Ligands, Part III [1]: Synthesis and Biological Activities of 7, 7′—Alkylene-bis-6, 7, 8, 9, 14, 15-hexahydro-5H-benz[d]indolo[2, 3-g]azecines — Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist

Archiv der Pharmazie ◽

10.1002/1521-4184(200211)335:8<367::aid-ardp367>3.0.co;2-c ◽

2002 ◽

Vol 335 (8) ◽

pp. 367-373 ◽

Cited By ~ 14

Author(s):

Ashraf H. Abadi ◽

Stefan Lankow ◽

Barbara Hoefgen ◽

Michael Decker ◽

Matthias U. Kassack ◽

...

Keyword(s):

Receptor Antagonist ◽

Dopamine Receptor ◽

Serotonin Receptor ◽

Biological Activities ◽

Receptor Ligands ◽

Bivalent Ligand ◽

Dopamine Receptor Antagonist

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Dopamine/Serotonin Receptor Ligands. Part 3. Synthesis and Biological Activities of 7,7′-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo [2,3-g]azecines — Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist.

ChemInform ◽

10.1002/chin.200304166 ◽

2003 ◽

Vol 34 (4) ◽

Author(s):

Ashraf H. Abadi ◽

Stefan Lankow ◽

Barbara Hoefgen ◽

Michael Decker ◽

Matthias U. Kassack ◽

...

Keyword(s):

Receptor Antagonist ◽

Dopamine Receptor ◽

Serotonin Receptor ◽

Biological Activities ◽

Receptor Ligands ◽

Bivalent Ligand ◽

Dopamine Receptor Antagonist

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Dopamine/Serotonin Receptor Ligands. 131: Homologization of a Benzindoloazecine-Type Dopamine Receptor Antagonist Modulates the Affinities for Dopamine D1−D5Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm060213k ◽

2006 ◽

Vol 49 (21) ◽

pp. 6408-6411 ◽

Cited By ~ 12

Author(s):

Christoph Enzensperger ◽

Jochen Lehmann

Keyword(s):

Receptor Antagonist ◽

Dopamine Receptor ◽

Serotonin Receptor ◽

Receptor Ligands ◽

Dopamine Receptor Antagonist

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Meta-analysis of amisulpride — A selective dopamine receptor antagonist with an “atypical” profile

European Neuropsychopharmacology ◽

10.1016/s0924-977x(00)80396-x ◽

2000 ◽

Vol 10 ◽

pp. 326

Author(s):

S. Leucht ◽

G. Pitschel-Walz ◽

W. Kissling

Keyword(s):

Receptor Antagonist ◽

Dopamine Receptor ◽

Meta Analysis ◽

Dopamine Receptor Antagonist ◽

Selective Dopamine

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Effects of the dopamine receptor antagonist raclopride and the serotonin receptor antagonist LY 53857 alone and in combination on extracellular recordings of substantia nigra reticulata neurons of the rat brain

Schizophrenia Research ◽

10.1016/s0920-9964(97)88738-5 ◽

1998 ◽

Vol 29 (1-2) ◽

pp. 169

Author(s):

R. Bruggeman ◽

M.J. Heeringa ◽

B.H.C. Westerink ◽

W. Timmerman

Keyword(s):

Substantia Nigra ◽

Receptor Antagonist ◽

Rat Brain ◽

Dopamine Receptor ◽

Serotonin Receptor ◽

Dopamine Receptor Antagonist ◽

Extracellular Recordings ◽

Substantia Nigra Reticulata ◽

Serotonin Receptor Antagonist ◽

Ly 53857

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Dopamine/serotonin receptor ligands. Part VIII[1]:the dopamine receptor antagonist LE300 - modelled and X-ray structure plus further pharmacological characterization, including serotonin receptor binding, biogenic amine transporter testing and in vivo testings

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2004.02.001 ◽

2004 ◽

Vol 39 (6) ◽

pp. 481-489 ◽

Cited By ~ 12

Author(s):

Michael Decker ◽

Klaus-Jürgen Schleifer ◽

Martin Nieger ◽

Jochen Lehmann

Keyword(s):

Receptor Antagonist ◽

Receptor Binding ◽

Biogenic Amine ◽

Serotonin Receptor ◽

Receptor Ligands ◽

Pharmacological Characterization ◽

Dopamine Receptor Antagonist ◽

X Ray ◽

Serotonin Receptor Binding

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Effects of L-741,741, a selective dopamine receptor antagonist, on anxiety tested in the elevated plus-maze in mice

Methods and Findings in Experimental and Clinical Pharmacology ◽

10.1358/mf.2003.25.1.724862 ◽

2003 ◽

Vol 25 (1) ◽

pp. 45 ◽

Cited By ~ 4

Author(s):

J.F. Navarro ◽

G. Luna ◽

F. García ◽

C. Pedraza

Keyword(s):

Receptor Antagonist ◽

Dopamine Receptor ◽

Elevated Plus Maze ◽

Dopamine Receptor Antagonist ◽

Plus Maze ◽

Selective Dopamine

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Evaluation of Dual Injection of LHRHa and the Dopamine Receptor Antagonist Pimozide in Cage Spawning of Channel Catfish Ictalurus punctatus

Journal of the World Aquaculture Society ◽

10.1111/j.1749-7345.1999.tb00874.x ◽

1999 ◽

Vol 30 (2) ◽

pp. 263-268 ◽

Cited By ~ 22

Author(s):

Jeffrey T. Silverstein ◽

Brian G. Bosworth ◽

William R. Wolters

Keyword(s):

Receptor Antagonist ◽

Dopamine Receptor ◽

Ictalurus Punctatus ◽

Channel Catfish ◽

Dopamine Receptor Antagonist ◽

Dual Injection

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Effects of the D3 dopamine receptor antagonist, U99194A, on brain stimulation and d-amphetamine reward, motor activity, and c-fos expression in ad libitum fed and food-restricted rats

Psychopharmacology ◽

10.1007/s00213-002-1132-0 ◽

2002 ◽

Vol 163 (1) ◽

pp. 76-84 ◽

Cited By ~ 25

Author(s):

K. Carr ◽

N. Yamamoto ◽

M. Omura ◽

S. Cabeza de Vaca ◽

L. Krahne

Keyword(s):

Motor Activity ◽

Receptor Antagonist ◽

Dopamine Receptor ◽

Brain Stimulation ◽

Dopamine Receptor Antagonist ◽

Ad Libitum ◽

Fos Expression

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BUSPIRONE AS A DOPAMINE RECEPTOR ANTAGONIST IN DRUG DISCRIMINATION

Behavioural Pharmacology ◽

10.1097/00008877-199210000-00016 ◽

1992 ◽

Vol 3 (5) ◽

pp. 527

Author(s):

BERENDSEN H.H. G. ◽

BROEKKAMP C.L. E.

Keyword(s):

Receptor Antagonist ◽

Drug Discrimination ◽

Dopamine Receptor ◽

Dopamine Receptor Antagonist

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