Synthesis and Biological Evaluation of Imidazoquinoxalinones, Imidazole Analogues of Pyrroloiminoquinone Marine Natural Products

2007 ◽  
Vol 50 (19) ◽  
pp. 4561-4571 ◽  
Author(s):  
Hung Hoang ◽  
Daniel V. LaBarbera ◽  
Kaleem A. Mohammed ◽  
Chris M. Ireland ◽  
Edward B. Skibo
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

The first total synthesis and biological evaluation of marine natural products ma’edamines A and B

2013 ◽  
Vol 23 (4) ◽  
pp. 1013-1016 ◽  
Author(s):  
Sanjay Saha ◽  
Ch. Venkata Ramana Reddy ◽  
T. Chiranjeevi ◽  
Uma Addepally ◽  
T.S. Chinta Rao ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Total synthesis and biological evaluation of ustiloxin natural products and two analogs

2006 ◽  
Vol 16 (18) ◽  
pp. 4804-4807 ◽  
Author(s):  
Pixu Li ◽  
Cory D. Evans ◽  
Erin M. Forbeck ◽  
Haengsoon Park ◽  
Ruoli Bai ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

MedChemComm ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 1205-1211
Author(s):  
Alhanouf Z. Aljahdali ◽  
Seth A. Freedman ◽  
Jana Scott ◽  
Miaosheng Li ◽  
George A. O'Doherty
Keyword(s):  
Natural Products ◽  
Biological Evaluation ◽  
Anticancer Activities ◽  
Synthesis And Biological Evaluation

The synthesis and biological evaluation of two phomopsolide natural products (D and E) and two analogues is presented.

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