A Structure–Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are δ/μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

Takashi Yamamoto; Padma Nair; Josef Vagner; Tally Largent-Milnes; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Henry I. Yamamura; Todd W. Vanderah; Frank Porreca; Victor J. Hruby

doi:10.1021/jm070332f

A Structure–Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are δ/μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm070332f ◽

2008 ◽

Vol 51 (5) ◽

pp. 1369-1376 ◽

Cited By ~ 36

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Josef Vagner ◽

Tally Largent-Milnes ◽

Peg Davis ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Synthetic Approach ◽

Neurokinin 1 Receptor ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Relationship Study ◽

Neurokinin 1 ◽

Opioid Receptor Agonists

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Design, Synthesis, and Structure–Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00487 ◽

2020 ◽

Author(s):

Huoming Huang ◽

Xinwei Li ◽

Wei Guo ◽

Chen Zhu ◽

Yuanyuan Qian ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.6b00460 ◽

2017 ◽

Vol 8 (6) ◽

pp. 1327-1337 ◽

Cited By ~ 11

Author(s):

Stefan M. Noha ◽

Helmut Schmidhammer ◽

Mariana Spetea

Keyword(s):

Molecular Dynamics ◽

Molecular Docking ◽

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Development of κ Opioid Receptor Agonists by Focusing on Phenyl Substituents of 4-Dimethylamino-3-phenylpiperidine Derivatives: Structure–Activity Relationship Study of Matrine Type Alkaloids

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c15-00963 ◽

2016 ◽

Vol 64 (5) ◽

pp. 420-431 ◽

Cited By ~ 3

Author(s):

Hiroyoshi Teramoto ◽

Takayasu Yamauchi ◽

Shigeru Sasaki ◽

Kimio Higashiyama

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity ◽

Relationship Study ◽

Opioid Receptor Agonists

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Discovery, structure–activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.07.012 ◽

2014 ◽

Vol 22 (17) ◽

pp. 4694-4703 ◽

Cited By ~ 8

Author(s):

Ming-Fu Cheng ◽

Li-Chin Ou ◽

Shu-Chun Chen ◽

Wan-Ting Chang ◽

Ping-Yee Law ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm061369n ◽

2007 ◽

Vol 50 (12) ◽

pp. 2779-2786 ◽

Cited By ~ 40

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Peg Davis ◽

Shou-wu Ma ◽

Edita Navratilova ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Neurokinin 1 Receptor ◽

Modified Peptides ◽

Μ Opioid Receptor ◽

Neurokinin 1 ◽

Opioid Receptor Agonists ◽

Synthesis And Biological Evaluation

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Design, structure–activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.08.070 ◽

2011 ◽

Vol 19 (21) ◽

pp. 6430-6446 ◽

Cited By ~ 4

Author(s):

Junya Shirai ◽

Takeshi Yoshikawa ◽

Masayuki Yamashita ◽

Yasuharu Yamamoto ◽

Makiko Kawamoto ◽

...

Keyword(s):

Asymmetric Synthesis ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

Neurokinin 1 Receptor ◽

Highly Efficient ◽

Structure Activity ◽

Design Structure ◽

Neurokinin 1

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Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.5b00092 ◽

2015 ◽

Vol 6 (8) ◽

pp. 1411-1419 ◽

Cited By ~ 36

Author(s):

Kimberly M. Lovell ◽

Kevin J. Frankowski ◽

Edward L. Stahl ◽

Stephen R. Slauson ◽

Euna Yoo ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Kappa Opioid ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Structure-Activity Relationship Study of Nonpeptideδ-Opioid Receptor Ligands

Helvetica Chimica Acta ◽

10.1002/1522-2675(20011114)84:11<3299::aid-hlca3299>3.0.co;2-b ◽

2001 ◽

Vol 84 (11) ◽

pp. 3299-3305 ◽

Cited By ~ 4

Author(s):

Joaquín Lahsen ◽

Helmut Schmidhammer ◽

Bernd M. Rode

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Ligands ◽

Structure Activity ◽

Opioid Receptor Ligands ◽

Relationship Study

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Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.09.003 ◽

2017 ◽

Vol 126 ◽

pp. 202-217 ◽

Cited By ~ 6

Author(s):

Sheng-Ren Chen ◽

Yi-Yu Ke ◽

Teng-Kuang Yeh ◽

Shu-Yu Lin ◽

Li-Chin Ou ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Design and Synthesis of a Piperidinone Scaffold as an Analgesic through Kappa-Opioid Receptor: Structure–Activity Relationship Study of Matrine Alkaloids

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c15-00962 ◽

2016 ◽

Vol 64 (5) ◽

pp. 410-419 ◽

Cited By ~ 6

Author(s):

Hiroyoshi Teramoto ◽

Takayasu Yamauchi ◽

Yasushi Terado ◽

Sanae Odagiri ◽

Shigeru Sasaki ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Kappa Opioid ◽

Design And Synthesis ◽

Receptor Structure ◽

Structure Activity ◽

Relationship Study

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