Synthesis, Structure–Activity Relationship, and Pharmacological Studies of Novel Melanin-Concentrating Hormone Receptor 1 Antagonists 3-Aminomethylquinolines: Reducing Human Ether-a-go-go-Related Gene (hERG) Associated Liabilities

Activity Relationship ◽

Related Gene ◽

Structure Activity ◽

Pharmacological Studies ◽

Melanin-concentrating hormone receptor 1 antagonists: Synthesis, structure–activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.09.007 ◽

2011 ◽

Vol 19 (21) ◽

pp. 6261-6273 ◽

Cited By ~ 10

Author(s):

Shizuo Kasai ◽

Masahiro Kamaura ◽

Makoto Kamata ◽

Kazuyoshi Aso ◽

Hitomi Ogino ◽

...

Keyword(s):

Hormone Receptor ◽

Docking Studies ◽

Biological Evaluation ◽

Activity Relationship ◽

Structure Activity ◽

Synthesis and Structure–Activity Relationship of Naphtho[1,2-b]furan-2-carboxamide Derivatives as Melanin Concentrating Hormone Receptor 1 Antagonists

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c13-00486 ◽

2013 ◽

Vol 61 (12) ◽

pp. 1239-1247 ◽

Cited By ~ 8

Author(s):

Chae Jo Lim ◽

Jun Young Choi ◽

Byung Ho Lee ◽

Kwang-Seok Oh ◽

Kyu Yang Yi

Keyword(s):

Hormone Receptor ◽

Activity Relationship ◽

Structure Activity ◽

Melanin Concentrating Hormone ◽

Relationship Of

Three-dimensional quantitative structure–activity relationship CoMSIA/CoMFA and LeapFrog studies on novel series of bicyclo [4.1.0] heptanes derivatives as melanin-concentrating hormone receptor R1 antagonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2010.07.011 ◽

2010 ◽

Vol 45 (10) ◽

pp. 4509-4522 ◽

Cited By ~ 18

Author(s):

Alejandro Morales-Bayuelo ◽

Hernan Ayazo ◽

Ricardo Vivas-Reyes

Keyword(s):

Hormone Receptor ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Discovery, synthesis, and structure–activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.07.038 ◽

2011 ◽

Vol 19 (18) ◽

pp. 5539-5552 ◽

Cited By ~ 8

Author(s):

Makoto Kamata ◽

Toshiro Yamashita ◽

Toshihiro Imaeda ◽

Toshio Tanaka ◽

Jun Terauchi ◽

...

Keyword(s):

Hormone Receptor ◽

Activity Relationship ◽

Structure Activity ◽

Melanin Concentrating Hormone ◽

Relationship Of

Design, synthesis, and structure–activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptor β (TRβ) selective agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.12.002 ◽

2013 ◽

Vol 21 (3) ◽

pp. 592-607 ◽

Cited By ~ 5

Author(s):

Hiroaki Shiohara ◽

Tetsuya Nakamura ◽

Norihiko Kikuchi ◽

Tomonaga Ozawa ◽

Akane Matsuzawa ◽

...

Keyword(s):

Thyroid Hormone ◽

Hormone Receptor ◽

Thyroid Hormone Receptor ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Selective Agonists ◽

Thyroid Hormone Receptor Β

6-Acylamino-2-aminoquinolines as Potent Melanin-Concentrating Hormone 1 Receptor Antagonists. Identification, Structure−Activity Relationship, and Investigation of Binding Mode

Journal of Medicinal Chemistry ◽

10.1021/jm050103y ◽

2005 ◽

Vol 48 (18) ◽

pp. 5684-5697 ◽

Cited By ~ 43

Author(s):

Trond Ulven ◽

Thomas M. Frimurer ◽

Jean-Marie Receveur ◽

Paul Brian Little ◽

Øystein Rist ◽

...

Keyword(s):

Binding Mode ◽

Activity Relationship ◽

Receptor Antagonists ◽

Structure Activity ◽

Quantitative Structure-Activity Relationship Models for Predicting Biological Properties, Developed by Combining Structure- and Ligand-Based Approaches: An Application to the Human Ether-a-go-go-Related Gene Potassium Channel Inhibition

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2009.00873.x ◽

2009 ◽

Vol 74 (4) ◽

pp. 416-433 ◽

Cited By ~ 5

Author(s):

Alessio Coi ◽

Ilaria Massarelli ◽

Marilena Saraceno ◽

Niccolò Carli ◽

Lara Testai ◽

...

Keyword(s):

Potassium Channel ◽

Quantitative Structure Activity Relationship ◽

Biological Properties ◽

Activity Relationship ◽

Quantitative Structure ◽

Related Gene ◽

Structure Activity ◽

Channel Inhibition

Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Journal of Medicinal Chemistry ◽

10.1021/jm0204542 ◽

2003 ◽

Vol 46 (12) ◽

pp. 2413-2426 ◽

Cited By ~ 47

Author(s):

Richard W. Friesen ◽

Yves Ducharme ◽

Richard G. Ball ◽

Marc Blouin ◽

Louise Boulet ◽

...

Keyword(s):

Potassium Channel ◽

Binding Affinity ◽

Tertiary Alcohol ◽

Activity Relationship ◽

Related Gene ◽

Phosphodiesterase 4 ◽

Structure Activity

Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.301.2.427 ◽

2002 ◽

Vol 301 (2) ◽

pp. 427-434 ◽

Cited By ~ 187

Author(s):

Sean Ekins ◽

William J. Crumb ◽

R. Dustan Sarazan ◽

James H. Wikel ◽

Steven A. Wrighton

Keyword(s):

Potassium Channel ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Related Gene ◽

Structure Activity

Structure-Activity Relationship Studies of Melanin-concentrating Hormone (MCH)-related Peptide Ligands at SLC-1, the Human MCH Receptor

Journal of Biological Chemistry ◽

10.1074/jbc.m010727200 ◽

2001 ◽

Vol 276 (17) ◽

pp. 13554-13562 ◽

Cited By ~ 45

Author(s):

Valérie Audinot ◽

Philippe Beauverger ◽

Chantal Lahaye ◽

Thomas Suply ◽

Marianne Rodriguez ◽

...

Keyword(s):

Peptide Ligands ◽

Activity Relationship ◽

Related Peptide ◽

Structure Activity ◽