Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity

2012 ◽  
Vol 55 (9) ◽  
pp. 4521-4525 ◽  
Author(s):  
Won Jun Choi ◽  
Hwa-Jin Chung ◽  
Girish Chandra ◽  
Varughese Alexander ◽  
Long Xuan Zhao ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Broad Spectrum

scholarly journals SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules

2018 ◽  
Vol 17 (4) ◽  
pp. 763-775 ◽  
Author(s):  
Fang Wang ◽  
Li Zheng ◽  
Yuyao Yi ◽  
Zhuang Yang ◽  
Qiang Qiu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Broad Spectrum ◽  
Selective Inhibitor

scholarly journals MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

2008 ◽  
Vol 7 (4) ◽  
pp. 759-768 ◽  
Author(s):  
Marielle Fournel ◽  
Claire Bonfils ◽  
Yu Hou ◽  
Pu Theresa Yan ◽  
Marie-Claude Trachy-Bourget ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Broad Spectrum ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

2008 ◽  
Vol 7 (5) ◽  
pp. 1054-1065 ◽  
Author(s):  
Christian A. Hassig ◽  
Kent T. Symons ◽  
Xin Guo ◽  
Phan-Manh Nguyen ◽  
Tami Annable ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Broad Spectrum ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor

Tissue distribution of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rats by a RP-HPLC method with fluorescence detection/UV detection

2015 ◽  
Vol 7 (18) ◽  
pp. 7690-7696 ◽  
Author(s):  
Changmin Shao ◽  
Jian Zheng ◽  
Bo Fan ◽  
Shaman Luo ◽  
Jixiang Lin ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tissue Distribution ◽  
Fluorescence Detection ◽  
Broad Spectrum ◽  
Hplc Method ◽  
Uv Detection ◽  
Camptotheca Acuminata ◽  
Rp Hplc ◽  
Derivatives Of

Both 10-methoxycamptothecin (MCPT) and 10-hydroxycamptothecin (HCPT) are natural derivatives of camptothecin (CPT) isolated from Camptotheca acuminata, possessing broad-spectrum antitumor activity.

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity

2000 ◽  
Vol 59 (8) ◽  
pp. 983-991 ◽  
Author(s):  
Rick A Finch ◽  
Mao-Chin Liu ◽  
Susan P Grill ◽  
William C Rose ◽  
Regina Loomis ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ribonucleotide Reductase ◽  
Broad Spectrum ◽  
Potent Inhibitor ◽  
Reductase Activity ◽  
Ribonucleotide Reductase Activity

SJG-136 (NSC 694501), A Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

2004 ◽  
Vol 64 (18) ◽  
pp. 6700-6706 ◽  
Author(s):  
Michael C. Alley ◽  
Melinda G. Hollingshead ◽  
Christine M. Pacula-Cox ◽  
William R. Waud ◽  
John A. Hartley ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Broad Spectrum ◽  
Minor Groove ◽  
Cross Linking ◽  
Dna Minor Groove

scholarly journals TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor Activity in Multiple Dosing Regimens

2011 ◽  
Vol 11 (3) ◽  
pp. 700-709 ◽  
Author(s):  
Yuichi Hikichi ◽  
Kohei Honda ◽  
Kouki Hikami ◽  
Hitoshi Miyashita ◽  
Isao Kaieda ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Broad Spectrum ◽  
Selective Inhibitor ◽  
Multiple Dosing ◽  
Dosing Regimens
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