Discovery and Evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity

2008 ◽  
Vol 51 (19) ◽  
pp. 5897-5900 ◽  
Author(s):  
Upender Velaparthi ◽  
Mark Wittman ◽  
Peiying Liu ◽  
Joan M. Carboni ◽  
Francis Y. Lee ◽  
...  
Keyword(s):  
Growth Factor ◽  
Antitumor Activity ◽  
Broad Spectrum ◽  
Insulin Like Growth Factor ◽  
Receptor Kinase ◽  
In Vivo Antitumor Activity

Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

2005 ◽  
Vol 48 (18) ◽  
pp. 5639-5643 ◽  
Author(s):  
Mark Wittman ◽  
Joan Carboni ◽  
Ricardo Attar ◽  
Balu Balasubramanian ◽  
Praveen Balimane ◽  
...  
Keyword(s):  
Growth Factor ◽  
Antitumor Activity ◽  
Insulin Like Growth Factor ◽  
Receptor Kinase ◽  
Factor I ◽  
In Vivo Antitumor Activity ◽  
Growth Factor I

scholarly journals Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

2007 ◽  
Vol 6 (4) ◽  
pp. 1357-1367 ◽  
Author(s):  
Ta-Jen Liu ◽  
Tiffany LaFortune ◽  
Toshiyuki Honda ◽  
Osamu Ohmori ◽  
Shinji Hatakeyama ◽  
...  
Keyword(s):  
Growth Factor ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Insulin Like Growth Factor ◽  
Receptor Kinase ◽  
Factor I ◽  
Growth Factor I ◽  
Proliferation In Vitro

scholarly journals Antitumor Activity of the Insulin-Like Growth Factor-I Receptor Kinase Inhibitor NVP-AEW541 in Musculoskeletal Tumors

2005 ◽  
Vol 65 (9) ◽  
pp. 3868-3876 ◽  
Author(s):  
Katia Scotlandi ◽  
Maria Cristina Manara ◽  
Giordano Nicoletti ◽  
Pier-Luigi Lollini ◽  
Stella Lukas ◽  
...  
Keyword(s):  
Growth Factor ◽  
Antitumor Activity ◽  
Kinase Inhibitor ◽  
Insulin Like Growth Factor ◽  
Receptor Kinase ◽  
Factor I ◽  
Musculoskeletal Tumors ◽  
Growth Factor I

Relationship Between Growth Hormone in vivo Bioactivity, the Insulin-Like Growth Factor-I System and Bone Mineral Density in Young, Physically Fit Men and Women

2008 ◽  
Author(s):  
B. C. Nindl ◽  
J. R. Pierce ◽  
M. J. Durkot ◽  
A. P. Tuckow ◽  
M. J. Kennett ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Growth Factor ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Men And Women ◽  
Factor I ◽  
Growth Factor I

scholarly journals Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity

2000 ◽  
Vol 97 (6) ◽  
pp. 2573-2578 ◽  
Author(s):  
M. L. Gagnon ◽  
D. R. Bielenberg ◽  
Z.'e. Gechtman ◽  
H.-Q. Miao ◽  
S. Takashima ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Antitumor Activity ◽  
Vascular Endothelial ◽  
Neuropilin 1 ◽  
In Vivo Expression ◽  
Endothelial Growth Factor

scholarly journals Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.

1991 ◽  
Vol 266 (11) ◽  
pp. 7300-7305
Author(s):  
H L Foyt ◽  
D LeRoith ◽  
C T Roberts
Keyword(s):  
Growth Factor ◽  
Differential Association ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Mrna Variants ◽  
Growth Factor I
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