Targeting Matrix Metalloproteinases: Exploring the Dynamics of the S1′ Pocket in the Design of Selective, Small Molecule Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm500505f ◽

2014 ◽

Vol 57 (24) ◽

pp. 10205-10219 ◽

Author(s):

Benjamin Fabre ◽

Ana Ramos ◽

Beatriz de Pascual-Teresa

Keyword(s):

Matrix Metalloproteinases ◽

Small Molecule ◽

Small Molecule Inhibitors

Download Full-text

Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ◽

10.1016/j.bbamcr.2017.04.011 ◽

2017 ◽

Vol 1864 (11) ◽

pp. 2001-2014 ◽

Author(s):

Jayda E. Meisel ◽

Mayland Chang

Keyword(s):

Matrix Metalloproteinases ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Download Full-text

Molecular Imaging of Matrix Metalloproteinases In Vivo Using Small Molecule Inhibitors for SPECT and PET

Current Medicinal Chemistry ◽

10.2174/092986706778522002 ◽

2006 ◽

Vol 13 (23) ◽

pp. 2819-2838 ◽

Author(s):

S. Wagner ◽

H.-J. Breyholz ◽

A. Faust ◽

C. Holtke ◽

B. Levkau ◽

...

Keyword(s):

Molecular Imaging ◽

Matrix Metalloproteinases ◽

Small Molecule ◽

Small Molecule Inhibitors

Download Full-text

From molecular diagnostics to molecular targeted therapy with natural product small molecule inhibitors in oral squamous cell carcinoma

Planta Medica ◽

10.1055/s-2007-986722 ◽

2007 ◽

Vol 73 (09) ◽

Author(s):

VB Konkimalla ◽

VL Suhas ◽

NR Chandra ◽

E Gebhart ◽

T Efferth

Keyword(s):

Squamous Cell Carcinoma ◽

Targeted Therapy ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Natural Product ◽

Molecular Diagnostics ◽

Small Molecule ◽

Squamous Cell ◽

Molecular Targeted Therapy ◽

Small Molecule Inhibitors

Download Full-text

Faculty Opinions recommendation of Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1004750.54854 ◽

2002 ◽

Author(s):

Carol Otey

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors

Download Full-text

Faculty Opinions recommendation of Identification of small molecule inhibitors of anthrax lethal factor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016978.201559 ◽

2004 ◽

Author(s):

Kristina Downing

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Lethal Factor ◽

Anthrax Lethal Factor

Download Full-text

Faculty Opinions recommendation of Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1017973.285766 ◽

2005 ◽

Author(s):

George Perry

Keyword(s):

Small Molecule ◽

Amyloid Beta ◽

Small Molecule Inhibitors

Download Full-text

Faculty Opinions recommendation of High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023153.264839 ◽

2005 ◽

Author(s):

Robert Kelley

Keyword(s):

T Cell ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Download Full-text

Faculty Opinions recommendation of Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1024840.292879 ◽

2005 ◽

Author(s):

Chandra Kumar

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Phosphoinositide Dependent Kinase

Download Full-text

Faculty Opinions recommendation of Identification of new small molecule inhibitors of cystic fibrosis transmembrane conductance regulator protein: in vitro and in vivo studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1069767.522696 ◽

2007 ◽

Author(s):

Kim Barrett

Keyword(s):

Cystic Fibrosis ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

In Vivo Studies ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Regulator Protein ◽

Cystic Fibrosis Transmembrane

Download Full-text

Faculty Opinions recommendation of Discovery and characterization of small molecule inhibitors of the BET family bromodomains.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13411091.14784061 ◽

2011 ◽

Author(s):

Martin Stahl

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors

Download Full-text