Thiopyrophosphoantigens: Solid-phase Synthesis and in Vitro Characterization of a New Class of Vγ9 Vδ2 T Cells Activators

2009 ◽  
Vol 52 (12) ◽  
pp. 3716-3722 ◽  
Author(s):  
Perla Breccia ◽  
Francesca Angeli ◽  
Ilaria Cerbara ◽  
Alessandra Topai ◽  
Giovanni Auricchio ◽  
...  
Keyword(s):  
T Cells ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
New Class ◽  
In Vitro Characterization

Oxytocin analogues with non-coded amino acid residues in position 8: [8-Neopentylglycine]oxytocin and [8-cycloleucine]oxytocin

1987 ◽  
Vol 52 (9) ◽  
pp. 2317-2325 ◽  
Author(s):  
Jan Hlaváček ◽  
Jan Pospíšek ◽  
Jiřina Slaninová ◽  
Walter Y. Chan ◽  
Victor J. Hruby
Keyword(s):  
Amino Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
The Other ◽  
Amino Acid Residues ◽  
Phase Synthesis ◽  
Other Hand ◽  
Fragment Condensation

[8-Neopentylglycine]oxytocin (II) and [8-cycloleucine]oxytocin (III) were prepared by a combination of solid-phase synthesis and fragment condensation. Both analogues exhibited decreased uterotonic potency in vitro, each being about 15-30% that of oxytocin. Analogue II also displayed similarly decreased uterotonic potency in vivo and galactogogic potency. On the other hand, analogue III exhibited almost the same potency as oxytocin in the uterotonic assay in vivo and in the galactogogic assay.

Total solid-phase synthesis, purification and characterization of human parathyroid hormone-(1-84)

Biochemistry ◽  
1983 ◽  
Vol 22 (11) ◽  
pp. 2691-2697 ◽  
Author(s):  
T. Fairwell ◽  
A. V. Hospattankar ◽  
R. Ronan ◽  
H. B. Brewer ◽  
J. K. Chang ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Total Solid ◽  
Human Parathyroid Hormone ◽  
Purification And Characterization ◽  
Phase Synthesis

scholarly journals Solid-Phase Synthesis and Kinetic Characterization of Fluorogenic Enzyme-Degradable Hydrogel Cross-linkers

2006 ◽  
Vol 7 (4) ◽  
pp. 1011-1016 ◽  
Author(s):  
Jason A. Moss ◽  
Shula Stokols ◽  
Mark S. Hixon ◽  
Fawn T. Ashley ◽  
Jason Y. Chang ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Kinetic Characterization ◽  
Phase Synthesis

[MeArg1, NLe10]-apelin-12: Optimization of solid-phase synthesis and evaluation of biological properties in vitro and in vivo

Peptides ◽  
2020 ◽  
Vol 129 ◽  
pp. 170320 ◽  
Author(s):  
Maria Sidorova ◽  
Irina Studneva ◽  
Valery Bushuev ◽  
Marina Pal’keeva ◽  
Alexander Molokoedov ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Properties ◽  
Phase Synthesis

A convenient solid-phase synthesis methodology for preparing peptide-derived molecular imaging agents — Synthesis, characterization, and in vitro screening of Tc(I) – chemotactic peptide conjugates

2005 ◽  
Vol 83 (12) ◽  
pp. 2060-2066 ◽  
Author(s):  
Karin A Stephenson ◽  
Sangeeta Ray Banerjee ◽  
Nicole McFarlane ◽  
Douglas R Boreham ◽  
Kevin P Maresca ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Metal Chelate ◽  
Free Ligand ◽  
Peptide Sequence ◽  
In Vitro Screening ◽  
Chemotactic Peptide ◽  
Phase Synthesis ◽  
Synthesis Strategy

A versatile solid-phase synthesis strategy for preparing peptide–chelate conjugates was developed. The methodology was optimized using a series of ligands, designed to bind Tc(I)/Re(I), and a chemotactic peptide fMFL, which was exploited as a model targeting vector. The peptide derivatives were prepared in parallel using a conventional automated peptide synthesizer in multi-milligram quantities, which provided sufficient material to perform complete characterization, radiolabelling, and in vitro screening studies. Because of the robust nature of the metal–chelate complexes, the Re complex of a chelate–peptide conjugate was prepared on the resin using the same methodology employed to prepare the free ligand conjugates. As such, the reported methodology is amenable to the preparation of libraries of novel Tc radiopharmaceutical ligands and their corresponding Re reference standards in which several factors, including peptide sequence, site of derivatization, and both the type and length of the spacer, can be easily varied.Key words: radiopharmaceuticals, technetium, rhenium, peptides, solid-phase synthesis.

scholarly journals Peptidines: glycine-amidine-based oligomers for solution- and solid-phase synthesis

2016 ◽  
Vol 7 (5) ◽  
pp. 3317-3324 ◽  
Author(s):  
Julian Vastl ◽  
Rendy Kartika ◽  
Kichul Park ◽  
Art E. Cho ◽  
David A. Spiegel
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
New Class ◽  
Synthetic Procedure

We introduce a modular synthetic procedure to produce a new class of synthetic oligomers called peptidines composed of repeating di-substituted glycine-derived amidines.

Solid-phase synthesis and characterization of carcinoembryonic antigen (CEA) domains

2009 ◽  
Vol 52 (4) ◽  
pp. 249-260 ◽  
Author(s):  
B.E. Kaplan ◽  
L.J. Hefta ◽  
R.C. Blake II ◽  
K.M. Swiderek ◽  
J.E. Shively
Keyword(s):  
Carcinoembryonic Antigen ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthesis And Characterization ◽  
Phase Synthesis
Sign in / Sign up

Export Citation Format

Share Document