Temporary Inactivation of Plasma Amine Oxidase by Alkylhydrazines. A Combined Enzyme/Model Study Implicates Cofactor Reduction/Reoxidation but Cofactor Deoxygenation and Subsequent Reoxygenation in the Case of Hydrazine Itself

2001 ◽  
Vol 66 (6) ◽  
pp. 1925-1937 ◽  
Author(s):  
Younghee Lee ◽  
Heung-Bae Jeon ◽  
He Huang ◽  
Lawrence M. Sayre
Keyword(s):  
Amine Oxidase ◽  
Model Study ◽  
Enzyme Model ◽  
Plasma Amine Oxidase

Amine oxidase. XII. Association and dissociation, and number of subunits of beef plasma amine oxidase

Biochemistry ◽  
1968 ◽  
Vol 7 (12) ◽  
pp. 4329-4335 ◽  
Author(s):  
Frances M. Achee ◽  
Charles H. Chervenka ◽  
Richard A. Smith ◽  
Kerry T. Yasunobu
Keyword(s):  
Amine Oxidase ◽  
Plasma Amine Oxidase

Purification and active-site characterization of equine plasma amine oxidase

1994 ◽  
Vol 56 (2) ◽  
pp. 127-141 ◽  
Author(s):  
Scott R. Carter ◽  
Michele A. McGuirl ◽  
Doreen E. Brown ◽  
David M. Dooley
Keyword(s):  
Active Site ◽  
Amine Oxidase ◽  
Site Characterization ◽  
Equine Plasma ◽  
Plasma Amine Oxidase

Novel inactivators of plasma amine oxidase

1975 ◽  
Vol 97 (19) ◽  
pp. 5613-5614 ◽  
Author(s):  
Alan L. Maycock ◽  
Robert H. Suva ◽  
Robert H. Abeles
Keyword(s):  
Amine Oxidase ◽  
Plasma Amine Oxidase

Biogenic amine-related enzymes and personality variations in normals

1977 ◽  
Vol 7 (1) ◽  
pp. 149-157 ◽  
Author(s):  
D. L. Murphy ◽  
R. H. Belmaker ◽  
M. Buchsbaum ◽  
N. F. Martin ◽  
R. Ciaranello ◽  
...  
Keyword(s):  
Biogenic Amine ◽  
Sensation Seeking ◽  
Amine Oxidase ◽  
Psychiatric Patients ◽  
Chronic Schizophrenia ◽  
Personality Variables ◽  
Scale Scores ◽  
Plasma Amine Oxidase ◽  
Positive Correlations ◽  
Sensation Seeking Scale

SynopsisAltered activities of biogenic amine-related enzymes have been reported in some studies of patients with affective disorders and chronic schizophrenia. To evaluate whether any relationship between personality variations, including non-diagnosed psychopathology, and these enzymes might occur in non-psychiatric patients, 95 young adult volunteers were studied. Higher MMPI and Zuckerman sensation-seeking scale scores were found in male, but not female, volunteers with lower platelet and plasma amine oxidase activities. Males generally exhibited negative correlations, while females had positive correlations between the psychological test scores and amine oxidase activities. In contrast to the amine oxidase results, no associations were observed between plasma dopamine β-hydroxylase activities and the personality variables.

scholarly journals Electron nuclear double-resonance (ENDOR) spectroscopy of amine oxidase from pig plasma

1986 ◽  
Vol 237 (2) ◽  
pp. 609-612 ◽  
Author(s):  
G J Baker ◽  
P F Knowles ◽  
K B Pandeya ◽  
J B Rayner
Keyword(s):  
Hyperfine Coupling ◽  
Amine Oxidase ◽  
Double Resonance ◽  
Spectroscopic Studies ◽  
Water Molecules ◽  
Electron Nuclear Double Resonance ◽  
Endor Spectroscopy ◽  
Amino Acid Histidine ◽  
Plasma Amine Oxidase ◽  
Hyperfine Couplings

Electron nuclear double-resonance (‘ENDOR’) spectroscopic studies on pig plasma amine oxidase have been carried out at 15 K. Deuterium-exchange studies show the presence of two sets of exchangeable protons, probably from two water molecules; from the magnitude of their hyperfine couplings, one is assigned to be equatorially, and the other axially, co-ordinated. Only one 14N hyperfine coupling is observed, suggesting that the bonding of all amino acid (histidine) or organic cofactor ligands is similar. Upon addition of azide, a further hyperfine coupling to nitrogen is observed which is smaller than that observed for the native enzyme; the hyperfine couplings to the remaining nitrogens are slightly altered.

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