Green Chemistry Approaches to the Synthesis of 5-Alkoxycarbonyl-4-aryl-3,4- dihydropyrimidin-2(1H)-ones by a Three-Component Coupling of One-Pot Condensation Reaction:  Comparison of Ethanol, Water, and Solvent-free Conditions

2003 ◽  
Vol 68 (2) ◽  
pp. 587-590 ◽  
Author(s):  
D. Subhas Bose ◽  
Liyakat Fatima ◽  
Hari Babu Mereyala
Keyword(s):  
Green Chemistry ◽  
Condensation Reaction ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
One Pot Condensation ◽  
Three Component Coupling

scholarly journals Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Saeed Khodabakhshi
Keyword(s):  
Green Chemistry ◽  
Organic Solvents ◽  
Condensation Reaction ◽  
Reaction Times ◽  
Solvent Free ◽  
Coumarin Derivatives ◽  
Inexpensive Method ◽  
Keto Esters ◽  
Pechmann Condensation ◽  
Solvent Free Conditions

Various coumarin derivatives have been efficiently synthesized via barium dichloride-catalyzed Pechmann condensation reaction of various phenols and β-keto esters under solvent-free conditions. This novel and inexpensive method has advantages such as short reaction times, excellent product yields, and avoidance of organic solvents in agreement with green chemistry principles.

Antimony(III) chloride impregnated on alumina — An efficient and economical Lewis acid catalyst for one-pot synthesis of dihydropyrimidinones under solvent-free conditions

2006 ◽  
Vol 84 (3) ◽  
pp. 433-437 ◽  
Author(s):  
Kamal K Kapoor ◽  
Bilal A Ganai ◽  
Satish Kumar ◽  
Charanjeet S Andotra
Keyword(s):  
Lewis Acid ◽  
Condensation Reaction ◽  
Thermal Conditions ◽  
Acid Catalyst ◽  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Lewis Acid Catalyst

The antimony(III) chloride impregnated on alumina efficiently catalyses a one-pot, three-component condensation reaction among an aldehyde, a β-ketoester, and urea or thiourea to afford the corresponding dihydropyrimidinones in good to excellent yields. The reactions are probed in microwave (MW), ultrasonic, and thermal conditions and the best results are found using MW under solvent-free conditions.Key words: Biginelli dihydropyrimidinones synthesis, SbCl3–Al2O3, MW, sonication, solid supported.

Synthesis of 4-selenylidene-4H,5H-chromeno[3,4-e][1,3]oxazin-5-one

2017 ◽  
Vol 41 (8) ◽  
pp. 452-454 ◽  
Author(s):  
Rahele Zhiani
Keyword(s):  
Ambient Temperature ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
One Pot ◽  
Acyl Chlorides ◽  
Solvent Free Conditions ◽  
One Pot Condensation

A green and efficient synthesis of [1,3]oxazines has been achieved via a three-component, one-pot condensation of 4-hydroxycoumarin, potassium selenocyanate and acyl chlorides in the presence of N-methylimidazole under solvent-free conditions at ambient temperature.

scholarly journals One Pot, Solvent-Free Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-Ones/Thiones under Microwave Irradiation (CEM) Using Reusable Nickel Nanoparticles

2015 ◽  
Vol 50 ◽  
pp. 17-25 ◽  
Author(s):  
Mayur K. Vekariya ◽  
Rajesh H. Vekariya ◽  
Nirav N. Barot ◽  
Tauhid A. Shaikh ◽  
Harjinder Kaur ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Nickel Nanoparticles ◽  
Condensation Reaction ◽  
Solvent Free ◽  
High Yield ◽  
One Pot ◽  
Mass Spectral ◽  
Keto Esters ◽  
Aryl Aldehydes ◽  
Solvent Free Conditions

A library of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were synthesized via Biginelli condensation reaction of β-keto esters, aryl aldehydes and urea/thiourea under solvent-free conditions utilizing nickel nanoparticles under microwave irradiation (CEM Discover). The structures of the all compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and Mass spectral data. Nickel nanoparticles can be recovered and reused five times without loss of their efficiency. Short reaction time, high yield of products and simple workup procedure, solvent-free conditions and reusability of the catalyst are the superior features of this protocol.

scholarly journals Zr(HSO4)4: An Efficient Catalyst for the Synthesis of 3-(2'- Benzothiazolyl)-2,3-dihydroquinazolin- 4(1H)-ones

2012 ◽  
Vol 9 (2) ◽  
pp. 739-743 ◽  
Author(s):  
Liqiang Wu
Keyword(s):  
Solvent Free ◽  
Isatoic Anhydride ◽  
Efficient Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Solvent Free Conditions ◽  
One Pot Condensation ◽  
The One

A simple and efficient synthesis of 3-(2'-benzothiazolyl)-2,3-dihydro quinazolin-4(1H)- ones has been accomplished by the one-pot condensation of isatoic anhydride, aldehyde and 2-aminobenzothiazole under solvent-free conditions in the presence of Zr(HSO4)4.

scholarly journals Efficient Synthesis of 1-Amidoalkyl-2-Naphthols by One-Pot, Three-Component Reaction under Solvent-Free Conditions

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Zahed Karimi-Jaberi ◽  
Marziyeh Jokar ◽  
S. Zoleykha Abbasi
Keyword(s):  
Trichloroacetic Acid ◽  
Reaction Times ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Three Component Reaction ◽  
One Pot Condensation ◽  
High Yields ◽  
Free Media

Two efficient and direct procedures have been developed for the preparation of 1-amidoalkyl-2-naphthols by a one-pot condensation of aldehydes, 2-naphthol, and amides in the presence of trichloroacetic acid or cobalt (II) chloride as catalyst. The reactions were carried out under solvent-free media. High yields, short reaction times, easy workup of the catalyst are advantages of these procedures.

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