Mefenamic Acid Anti-Inflammatory Drug: Probing Its Polymorphs by Vibrational (IR and Raman) and Solid-State NMR Spectroscopies

2014 ◽  
Vol 118 (16) ◽  
pp. 4333-4344 ◽  
Author(s):  
Vanessa R. R. Cunha ◽  
Celly M. S. Izumi ◽  
Philippe A. D. Petersen ◽  
Alviclér Magalhães ◽  
Marcia L. A. Temperini ◽  
...  
Keyword(s):  
Solid State ◽  
Mefenamic Acid ◽  
Solid State Nmr ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Ir And Raman

Synthesis and solid-state characterization of diclofenac imidazolium monohydrate: an imidazolium pharmaceutical ionic liquid

CrystEngComm ◽  
2020 ◽  
Vol 22 (32) ◽  
pp. 5345-5354
Author(s):  
Cecilia C. P. da Silva ◽  
Bolaji C. Dayo Owoyemi ◽  
Benedito R. Alvarenga-Jr ◽  
Natalia Alvarez ◽  
Javier Ellena ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Solid State ◽  
Solvent Evaporation ◽  
Inflammatory Drug ◽  
Hydrated Salt ◽  
Anti Inflammatory ◽  
Solid State Characterization

A new imidazolium hydrated salt (DCF–IMI–H2O) of the nonsteroidal anti-inflammatory drug diclofenac (DCF) was synthesized by solvent evaporation.

Hydrate modifications of the non-steroidal anti-inflammatory drug diclofenac sodium: Solid-state characterisation of a trihydrate form

2007 ◽  
Vol 45 (3) ◽  
pp. 443-449 ◽  
Author(s):  
Monica Bartolomei ◽  
Andrea Rodomonte ◽  
Eleonora Antoniella ◽  
Giuliano Minelli ◽  
Paola Bertocchi
Keyword(s):  
Solid State ◽  
Diclofenac Sodium ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Packing Interactions and Physicochemical Properties of Novel Multicomponent Crystal Forms of the Anti-Inflammatory Azelaic Acid Studied by X-ray and Solid-State NMR

2015 ◽  
Vol 16 (1) ◽  
pp. 154-166 ◽  
Author(s):  
Inês C. B. Martins ◽  
Mariana Sardo ◽  
Sérgio M. Santos ◽  
Auguste Fernandes ◽  
Alexandra Antunes ◽  
...  
Keyword(s):  
Solid State ◽  
Physicochemical Properties ◽  
Azelaic Acid ◽  
Solid State Nmr ◽  
Crystal Forms ◽  
X Ray ◽  
Anti Inflammatory ◽  
Packing Interactions

scholarly journals Novel Polymorphic Cocrystals of the Non-Steroidal Anti-Inflammatory Drug Niflumic Acid: Expanding the Pharmaceutical Landscape

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2140
Author(s):  
Francisco Javier Acebedo-Martínez ◽  
Carolina Alarcón-Payer ◽  
Antonio Frontera ◽  
Rafael Barbas ◽  
Rafel Prohens ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Solid State ◽  
Pharmaceutical Industry ◽  
Thermal Analyses ◽  
Active Pharmaceutical Ingredient ◽  
Niflumic Acid ◽  
X Ray Diffraction ◽  
Inflammatory Drug ◽  
X Ray ◽  
Anti Inflammatory

Any time the pharmaceutical industry develops a new drug, potential polymorphic events must be thoroughly described, because in a crystalline pharmaceutical solid, different arrangements of the same active pharmaceutical ingredient can yield to very different physicochemical properties that might be crucial for its efficacy, such as dissolution, solubility, or stability. Polymorphism in cocrystal formulation cannot be neglected, either. In this work, two different cocrystal polymorphs of the non-steroidal anti-inflammatory drug niflumic acid and caffeine are reported. They have been synthesized by mechanochemical methods and thoroughly characterized in solid-state by powder and single crystal X-ray diffraction respectively, as well as other techniques such as thermal analyses, infrared spectroscopy and computational methods. Both theoretical and experimental results are in agreement, confirming a conformational polymorphism. The polymorph NIF–CAF Form I exhibits improved solubility and dissolution rate compared to NIF–CAF Form II, although Form II is significantly more stable than Form I. The conditions needed to obtain these polymorphs and their transition have been carefully characterized, revealing an intricate system.

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