scholarly journals Pharmacokinetic and Biodistribution Studies of a Bone-Targeting Drug Delivery System Based onN-(2-Hydroxypropyl)methacrylamide Copolymers

2006 ◽  
Vol 3 (6) ◽  
pp. 717-725 ◽  
Author(s):  
Dong Wang ◽  
Monika Sima ◽  
R. Lee Mosley ◽  
Jasmine P. Davda ◽  
Nicole Tietze ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bone Targeting ◽  
Biodistribution Studies ◽  
Hydroxypropyl Methacrylamide

Targeting of soluble cross-linked N-(2-hydroxypropyl)methacrylamide copolymers in vivo. A potential drug delivery system

1984 ◽  
Vol 12 (6) ◽  
pp. 1064-1065 ◽  
Author(s):  
SUSAN A. CARTLIDGE ◽  
PAVLA REJMANOVÁ ◽  
RUTH DUNCAN ◽  
JINDŘICH KOPEČEK ◽  
JOHN B. LLOYD
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Drug ◽  
Hydroxypropyl Methacrylamide

Doxycycline containing hydroxyapatite ceramic microspheres as a bone‐targeting drug delivery system

2020 ◽  
Vol 108 (4) ◽  
pp. 1351-1362 ◽  
Author(s):  
Carlos Soriano‐Souza ◽  
Helder Valiense ◽  
Elena Mavropoulos ◽  
Victor Martinez‐Zelaya ◽  
Andrea Machado Costa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydroxyapatite Ceramic ◽  
Bone Targeting

scholarly journals Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 106 ◽  
Author(s):  
Larisa Janisova ◽  
Andrey Gruzinov ◽  
Olga V. Zaborova ◽  
Nadiia Velychkivska ◽  
Ondřej Vaněk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Plasma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Plasma Proteins ◽  
Molecular Mechanisms ◽  
Analytical Ultracentrifugation ◽  
Drug Carrier ◽  
Human Blood Plasma ◽  
Hydroxypropyl Methacrylamide

The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system. We investigate the possible interaction and the interaction mechanism of a polymeric drug delivery system based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA) with the most abundant proteins in human blood plasma—namely, human serum albumin (HSA), immunoglobulin G (IgG), fibrinogen (Fbg), and apolipoprotein (Apo) E4 and A1—using a combination of small-angle X-ray scattering (SAXS), analytical ultracentrifugation (AUC), and nuclear magnetic resonance (NMR). Through rigorous investigation, we present evidence of weak interactions between proteins and polymeric nanomedicine. Such interactions do not result in the formation of the protein corona and do not affect the efficiency of the drug delivery.

Osteotropic Nanoscale Drug Delivery System via a Single Aspartic Acid as the Bone-Targeting Moiety

2017 ◽  
Vol 17 (3) ◽  
pp. 1747-1752 ◽  
Author(s):  
Erica J Carbone ◽  
Komal Rajpura ◽  
Tao Jiang ◽  
Ho-Man Kan ◽  
Xiaohua Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Aspartic Acid ◽  
Delivery System ◽  
Bone Targeting
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