scholarly journals Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 106 ◽  
Author(s):  
Larisa Janisova ◽  
Andrey Gruzinov ◽  
Olga V. Zaborova ◽  
Nadiia Velychkivska ◽  
Ondřej Vaněk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Plasma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Plasma Proteins ◽  
Molecular Mechanisms ◽  
Analytical Ultracentrifugation ◽  
Drug Carrier ◽  
Human Blood Plasma ◽  
Hydroxypropyl Methacrylamide

The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system. We investigate the possible interaction and the interaction mechanism of a polymeric drug delivery system based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA) with the most abundant proteins in human blood plasma—namely, human serum albumin (HSA), immunoglobulin G (IgG), fibrinogen (Fbg), and apolipoprotein (Apo) E4 and A1—using a combination of small-angle X-ray scattering (SAXS), analytical ultracentrifugation (AUC), and nuclear magnetic resonance (NMR). Through rigorous investigation, we present evidence of weak interactions between proteins and polymeric nanomedicine. Such interactions do not result in the formation of the protein corona and do not affect the efficiency of the drug delivery.

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

scholarly journals Pharmacokinetic and Biodistribution Studies of a Bone-Targeting Drug Delivery System Based onN-(2-Hydroxypropyl)methacrylamide Copolymers

2006 ◽  
Vol 3 (6) ◽  
pp. 717-725 ◽  
Author(s):  
Dong Wang ◽  
Monika Sima ◽  
R. Lee Mosley ◽  
Jasmine P. Davda ◽  
Nicole Tietze ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bone Targeting ◽  
Biodistribution Studies ◽  
Hydroxypropyl Methacrylamide

Application of Abdominal Imaging Based on Nano Drug Delivery System for Diagnosis and Treatment of Liver Cancer

2021 ◽  
Vol 21 (2) ◽  
pp. 824-832
Author(s):  
Zhenzhen Fan ◽  
Qingsheng Liu ◽  
Fangfang Lu ◽  
Zhihui Dong ◽  
Peng Gao
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Liver Cancer ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Diagnosis And Treatment ◽  
Fluorescent Nanoparticles ◽  
Abdominal Image

Liver cancer has a high incidence and a poor prognosis, which seriously affects human health. Doxorubicin is one of the chemotherapeutics used in the treatment of tumours, but its severe adverse reactions, especially cardiac toxicity, have limited its clinical application. The nanometre drug delivery system enables drug-loaded nanoparticles to be specifically concentrated in tumour tissues, increasing cell uptake and improving curative effect. Therefore, in this paper, folic acid-modified mesoporous silica nanoparticles (MSN-NH2-PEG-FA) were synthesized by modifying the folic acid on the surface of a drug carrier by using the characteristics of the expression of folic acid receptors, and using it as a drug. The carrier was loaded with antitumor drug doxorubicin hydrochloride (DOX), and a nanometre drug delivery system (MSN-NH2-PEG-FA/DOX) was constructed. At the same time, the near-infrared dye Cy5 was used to mark the mother nucleus to construct fluorescent nanoparticles (MSN-NH2-PEG-FA/DOX-Cy5) for cell and tumour imaging, so as to obtain the abdominal image of liver cancer patients, thereby realizing diagnosis and treatment. The research results show that the carrier can specifically gather in the liver area, reduce the distribution in the heart, reduce the toxic and side effects of drugs, and prolong the survival time of patients. The results of this study provide new ideas for the treatment of liver cancer, and provide a new theoretical basis and experimental basis for the study of inorganic nanomaterials as targeted drug delivery systems.

An Implantable Immunosuppressive Cyclosporine Drug Delivery System

2005 ◽  
Vol 288-289 ◽  
pp. 125-128 ◽  
Author(s):  
Shen Guo Wang ◽  
Qing Cai ◽  
Jian Zhong Bei ◽  
Wei Yun Shi ◽  
Li Xin Xie
Keyword(s):  
Drug Delivery ◽  
Anterior Chamber ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Immunosuppressive Agent ◽  
Drug Preparation ◽  
Long Time ◽  
Clinically Significant

In the article a kind biodegradable drug carrier (glycolide-co-lactide-co-caprolactone) tricomponent copolymer (PGLC) was synthesized by ring opening copolymerization of glycolide (GA), lactide (LA) and ε-caprolactone (CL), and was used to manufacture an implantable drug preparation---Cyclosporine-PGLC drug delivery system (Cs-PGLC DDS).The Cs could slowly release from the Cs-PGLC DDS near linearly and last for a long time in vitro. A clinically significant Cs concentration in the cornea and anterior chamber could be achieved by implanting the Cs-PGLC DDS in anterior chamber. It was demonstrated that the Cs-PGLC DDS is a long-effective intraocular immunosuppressive agent for remaining corneal allograft clear and significantly prolong its survival time.

scholarly journals Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

2015 ◽  
Vol 112 (10) ◽  
pp. 2978-2983 ◽  
Author(s):  
Tuo Wei ◽  
Chao Chen ◽  
Juan Liu ◽  
Cheng Liu ◽  
Paola Posocco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Drug Carrier ◽  
Drug Loading ◽  
Cancer Drug ◽  
Self Assembling

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.

scholarly journals Nanoemulsion Drug Delivery System: A Review

2020 ◽  
Vol 11 (SPL4) ◽  
Author(s):  
Ashish B. Budhrani ◽  
Shubhra R. Rai ◽  
Aarati S. Panchbhai ◽  
Rajshri B. Dongarwar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Water System ◽  
Physicochemical Characteristics ◽  
High Energy ◽  
Low Energy ◽  
Emulsified Water ◽  
Nano Emulsion

Nano-emulsion dosage forms have nano-sized droplets of disperse phase and are kinetically stable dosage form. Nano-emulsions are included under the category of new drug delivery system containing emulsified water in oil/oil in water system having mean globule size ranges from 10 nm to 1000 nm.  In the field of pharmacy, nano-emulsions play an essential role in the delivery of medication through various drug administration routes like parenteral, topical and oral route. Nano-emulsions are nano-sized emulsions which are used under high investigation as a drug carrier for enhancing the delivery of therapeutic agents. Nano-emulsions have enhanced functional properties as compared to standard emulsions. They are nowadays growing work for utilizing nano-sized particles in the research of pharmaceuticals, cosmetics and food products.  Mainly, intrigue has been creating simultaneously with higher emulsification techniques and mechanisms of stabilization. Nano-emulsions are formulated by both methods like high energy emulsification or low energy emulsification methods. Rapid energy emulsification technique includes high shear mixing, high-pressure homogenization or ultrasonication. In contrast, low energy emulsification technique includes the merit of the physicochemical characteristics of the system, which exploits phase transitions to obtained nano-emulsion. This review article is an effort to summarize comparative aspects like introduction, types, advantages, disadvantages, components, factors affecting, methods of preparations, methods of analysis of nano-emulsion and applications of nano-emulsion.

An integrated targeting drug delivery system based on the hybridization of graphdiyne and MOFs for visualized cancer therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (24) ◽  
pp. 11709-11718 ◽  
Author(s):  
Zhongbo Xue ◽  
Mengyao Zhu ◽  
Yuze Dong ◽  
Tong Feng ◽  
Zhuozhi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Tumor Therapy ◽  
Framework Structure

Graphdiyne and UIO-66-NH2 form a framework structure as a drug carrier and apply to tumor therapy.

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