Structure–Activity Relationship Analysis of Bufadienolide-Induced in Vitro Growth Inhibitory Effects on Mouse and Human Cancer Cells

2013 ◽  
Vol 76 (6) ◽  
pp. 1078-1084 ◽  
Author(s):  
Laetitia Moreno Y. Banuls ◽  
Ernst Urban ◽  
Michel Gelbcke ◽  
François Dufrasne ◽  
Brigitte Kopp ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Activity Relationship ◽  
In Vitro Growth ◽  
Inhibitory Effects ◽  
Human Cancer Cells ◽  
Relationship Analysis ◽  
Structure Activity ◽  
Growth Inhibitory

scholarly journals Occurrence of a Taurine Derivative in an Antarctic Glass Sponge

2014 ◽  
Vol 9 (4) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Marianna Carbone ◽  
Laura Núñez-Pons ◽  
M. Letizia Ciavatta ◽  
Francesco Castelluccio ◽  
Conxita Avila ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Cancer Cells ◽  
Natural Product ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Butanol Extract ◽  
Human Cancer Cells ◽  
Hexactinellid Sponge ◽  
Growth Inhibitory

The n-butanol extract of an Antarctic hexactinellid sponge, Anoxycalyx (Scolymastra) joubini, was found to contain a taurine-conjugated anthranilic acid, never reported so far either as a natural product or by synthesis. The compound was inactive against human cancer cells in an in vitro growth inhibitory test, and also showed no antibacterial activity.

Glanduliferins A and B, two new glucosylated steroids from Impatiens glandulifera, with in vitro growth inhibitory activity in human cancer cells

Fitoterapia ◽  
2016 ◽  
Vol 109 ◽  
pp. 138-145 ◽  
Author(s):  
Alessio Cimmino ◽  
Véronique Mathieu ◽  
Marco Evidente ◽  
Marlène Ferderin ◽  
Laetitia Moreno Y Banuls ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Inhibitory Activity ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Impatiens Glandulifera ◽  
Human Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

scholarly journals In vitro growth inhibition of human cancer cells by novel honokiol analogs

2012 ◽  
Vol 20 (10) ◽  
pp. 3202-3211 ◽  
Author(s):  
Jyh Ming Lin ◽  
A.S. Prakasha Gowda ◽  
Arun K. Sharma ◽  
Shantu Amin
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Human Cancer Cells

In vitro growth inhibitory effects of 13,28-epoxyoleanane triterpene saponins in cancer cells

2013 ◽  
Vol 6 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Mohamed Haddad ◽  
Anne-Cécile Lelamer ◽  
Laetitia Moreno Y Banuls ◽  
Pedro Vasquez ◽  
Maelle Carraz ◽  
...  
Keyword(s):  
Cancer Cells ◽  
In Vitro Growth ◽  
Triterpene Saponins ◽  
Inhibitory Effects ◽  
Growth Inhibitory

scholarly journals BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7139
Author(s):  
Pedro Novais ◽  
Patrícia M. A. Silva ◽  
Joana Moreira ◽  
Andreia Palmeira ◽  
Isabel Amorim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Spindle Assembly Checkpoint ◽  
Human Cancer ◽  
Antitumor Agent ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Human Cancer Cells ◽  
Antimitotic Activity ◽  
Growth Inhibitory

Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitosis, which induce a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by massive apoptosis, as revealed by live cell imaging. Collectively, the results indicate that the diarylpentanoid BP-M345 exerts its antiproliferative activity by inhibiting mitosis through microtubule perturbation and causing cancer cell death, thereby highlighting its potential as antitumor agent.

In vitro growth inhibitory effects of 13, 28-epoxyoleanane triterpene saponins in cancer cells

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Haddad ◽  
AC Lelamer ◽  
L Moreno Y Banuls ◽  
M Carraz ◽  
P Vasquez ◽  
...  
Keyword(s):  
Cancer Cells ◽  
In Vitro Growth ◽  
Triterpene Saponins ◽  
Inhibitory Effects ◽  
Growth Inhibitory

scholarly journals Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase

2013 ◽  
Vol 12 (1) ◽  
pp. 33 ◽  
Author(s):  
Laetitia Moreno Y Banuls ◽  
Adriana Katz ◽  
Walter Miklos ◽  
Alessio Cimmino ◽  
Daniel M Tal ◽  
...  
Keyword(s):  
Cancer Cells ◽  
In Vitro Growth ◽  
Inhibitory Effects ◽  
Alpha Subunits ◽  
Growth Inhibitory
Sign in / Sign up

Export Citation Format

Share Document