Glanduliferins A and B, two new glucosylated steroids from Impatiens glandulifera, with in vitro growth inhibitory activity in human cancer cells

Fitoterapia ◽  
2016 ◽  
Vol 109 ◽  
pp. 138-145 ◽  
Author(s):  
Alessio Cimmino ◽  
Véronique Mathieu ◽  
Marco Evidente ◽  
Marlène Ferderin ◽  
Laetitia Moreno Y Banuls ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Inhibitory Activity ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Impatiens Glandulifera ◽  
Human Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

scholarly journals Occurrence of a Taurine Derivative in an Antarctic Glass Sponge

2014 ◽  
Vol 9 (4) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Marianna Carbone ◽  
Laura Núñez-Pons ◽  
M. Letizia Ciavatta ◽  
Francesco Castelluccio ◽  
Conxita Avila ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Cancer Cells ◽  
Natural Product ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Butanol Extract ◽  
Human Cancer Cells ◽  
Hexactinellid Sponge ◽  
Growth Inhibitory

The n-butanol extract of an Antarctic hexactinellid sponge, Anoxycalyx (Scolymastra) joubini, was found to contain a taurine-conjugated anthranilic acid, never reported so far either as a natural product or by synthesis. The compound was inactive against human cancer cells in an in vitro growth inhibitory test, and also showed no antibacterial activity.

scholarly journals Growth inhibitory activity of biflavonoids and diterpenoids from the leaves of the Libyan Juniperus phoenicea against human cancer cells

2019 ◽  
Vol 33 (8) ◽  
pp. 2075-2082 ◽  
Author(s):  
Afaf Al Groshi ◽  
Hiba A. Jasim ◽  
Andrew R. Evans ◽  
Fyaz M.D. Ismail ◽  
Nicola M. Dempster ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Inhibitory Activity ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Juniperus Phoenicea

Structure–Activity Relationship Analysis of Bufadienolide-Induced in Vitro Growth Inhibitory Effects on Mouse and Human Cancer Cells

2013 ◽  
Vol 76 (6) ◽  
pp. 1078-1084 ◽  
Author(s):  
Laetitia Moreno Y. Banuls ◽  
Ernst Urban ◽  
Michel Gelbcke ◽  
François Dufrasne ◽  
Brigitte Kopp ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Activity Relationship ◽  
In Vitro Growth ◽  
Inhibitory Effects ◽  
Human Cancer Cells ◽  
Relationship Analysis ◽  
Structure Activity ◽  
Growth Inhibitory

Cationic liposomes as efficient nanocarriers for the drug delivery of an anticancer cholesterol-based ruthenium complex

2015 ◽  
Vol 3 (15) ◽  
pp. 3011-3023 ◽  
Author(s):  
Giuseppe Vitiello ◽  
Alessandra Luchini ◽  
Gerardino D'Errico ◽  
Rita Santamaria ◽  
Antonella Capuozzo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Ruthenium Complex ◽  
Human Cancer ◽  
High Growth ◽  
Human Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Mcf 7

Cationic nanovectors loaded with Ru-based nucleolipids exert a high growth-inhibitory activity against human cancer cells (MCF-7 (A), WiDr (B), and HeLa (C)).

Novel juglone and plumbagin 5- O derivatives and their in vitro growth inhibitory activity against apoptosis-resistant cancer cells

2016 ◽  
Vol 26 (2) ◽  
pp. 334-337 ◽  
Author(s):  
Serena Fiorito ◽  
Salvatore Genovese ◽  
Vito Alessandro Taddeo ◽  
Véronique Mathieu ◽  
Robert Kiss ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Inhibitory Activity ◽  
In Vitro Growth ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

scholarly journals In vitro growth inhibition of human cancer cells by novel honokiol analogs

2012 ◽  
Vol 20 (10) ◽  
pp. 3202-3211 ◽  
Author(s):  
Jyh Ming Lin ◽  
A.S. Prakasha Gowda ◽  
Arun K. Sharma ◽  
Shantu Amin
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Human Cancer Cells

scholarly journals BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7139
Author(s):  
Pedro Novais ◽  
Patrícia M. A. Silva ◽  
Joana Moreira ◽  
Andreia Palmeira ◽  
Isabel Amorim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Spindle Assembly Checkpoint ◽  
Human Cancer ◽  
Antitumor Agent ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Human Cancer Cells ◽  
Antimitotic Activity ◽  
Growth Inhibitory

Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitosis, which induce a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by massive apoptosis, as revealed by live cell imaging. Collectively, the results indicate that the diarylpentanoid BP-M345 exerts its antiproliferative activity by inhibiting mitosis through microtubule perturbation and causing cancer cell death, thereby highlighting its potential as antitumor agent.

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