Endoplasmic Reticulum Stress Suppressive Compounds from the Edible Mushroom Mycoleptodonoides aitchisonii

2014 ◽  
Vol 77 (7) ◽  
pp. 1729-1733 ◽  
Author(s):  
Jae-Hoon Choi ◽  
Tomohiro Suzuki ◽  
Hiroshi Okumura ◽  
Keiichi Noguchi ◽  
Mitsuru Kondo ◽  
...  

Tetrahedron ◽  
2011 ◽  
Vol 67 (35) ◽  
pp. 6649-6653 ◽  
Author(s):  
Jae-Hoon Choi ◽  
Nobuhiko Ozawa ◽  
Yasuhiro Yamakawa ◽  
Kaoru Nagai ◽  
Hirofumi Hirai ◽  
...  


2015 ◽  
Vol 10 (4) ◽  
pp. 844 ◽  
Author(s):  
Jing-Wei Zhang ◽  
Gong-Ling Wen ◽  
Lei Zhang ◽  
Dong-Mei Duan ◽  
Zhong-Hai Ren

<p class="Abstract">A drimane type sesquiterpenoids, sulphureuine B was isolated from the edible mushroom <em>Laetiporus sulphureus</em> and its antiproliferative properties were investigated using U-87MG glioma cells. It was observed that sulphu-reuine B-induced apoptosis in U-87MG cells and the mechanisms involved are endoplasmic reticulum stress, mitochondrial and death receptor mediated pathways. Endoplasmic reticulum stress was identified from the results of enormous cytoplasmic vacuolation, CHOP elevation and caspase-12 cleavage. Further, we found that treatment of sulphureuine B-induced PERK, IRE1α, and ATF6α activations. In addition, sulphureuine B-induced Bcl-2 down-regulation, cleavage of PARP, and caspase-8 activation were also affected. All these experimental results clearly revealed that sulphureuine B-induced apoptosis mediated through endoplasmic reticulum stress, mitochondrial, and death receptor signaling pathways.</p><p> </p>



2015 ◽  
Vol 21 ◽  
pp. 85-86
Author(s):  
William Kurban ◽  
Salma Makhoul Ahwach ◽  
Melanie Thomas ◽  
Luisa Onsteed-Haas ◽  
Michael Haas










2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
G Metzger ◽  
P Di Fazio ◽  
DK Bartsch ◽  
T Gress ◽  
TT Wissniowski


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