Seven New Metabolites from the Marine Red Alga Laurencia majuscula

1993 ◽  
Vol 56 (3) ◽  
pp. 394-401 ◽  
Author(s):  
Anthony D. Wright ◽  
Gabriele M. König ◽  
Rocky de Nys ◽  
Otto Sticher
Keyword(s):  
Red Alga ◽  
Laurencia Majuscula ◽  
New Metabolites

scholarly journals Cytotoxicity and Antibacterial Potential of Halogenated Chamigrenes from Malaysian Red Alga, Laurencia majuscula

2019 ◽  
Vol 6 (02) ◽  
pp. e36-e40
Author(s):  
Takashi Kamada ◽  
Chin-Soon Phan ◽  
Tatsufumi Okino ◽  
Charles Santhanaraju Vairappan
Keyword(s):  
Spectroscopic Data ◽  
2D Nmr ◽  
Red Alga ◽  
Antibiotic Resistant ◽  
North Borneo ◽  
Bioactive Secondary Metabolites ◽  
Laurencia Majuscula ◽  
Mcf 7 ◽  
Antibacterial Potential ◽  
New Metabolites

AbstractRed algae of the genus Laurencia have been known to produce a wide array of bioactive secondary metabolites. Here, we report the isolation of two new halogenated chamigrenes, lauremantanones A (1) and B (2), along with seven known compounds, dendroidiol (3), (+)-elatol (4), cartilagineol (5), obtusol (6), (+)-laurencenone B (7), 2-chloro-3-hydroxy-α-chamigren-9-one (8), and puertitol A (9), from a population of Laurencia majuscula (Harvey) Lucas from Mantanani Island (North Borneo). The structures of the two new metabolites were determined based on spectroscopic data (IR, 1D and 2D NMR, and MS). Compounds isolated from this alga exhibited potent cytotoxic (HeLa, MCF-7, P-388) and antibacterial (against antibiotic-resistant clinical bacteria) activities. The major metabolite of this population has significant importance in the geographical distribution of this species globally.

Tropical Marine Algae. VIII. The Structural Determination of Novel Sesquiterpenoid Metabolites From the Red Alga .Laurencia majuscula

1992 ◽  
Vol 45 (10) ◽  
pp. 1611 ◽  
Author(s):  
R Denys ◽  
JC Coll ◽  
BF Bowden
Keyword(s):  
Natural Products ◽  
Great Barrier Reef ◽  
Marine Algae ◽  
Structural Type ◽  
Red Alga ◽  
Structural Determination ◽  
Barrier Reef ◽  
Natural Products Chemistry ◽  
Laurencia Majuscula

An investigation of the natural products chemistry of the red alga Laurencia mujuscula from the Great Barrier Reef yielded three novel metabolites, (1), (2) and (3a), possessing a new sesquiterpenoid structural type. Known metabolites (6)-(11) were also isolated and the reassignment of n.m.r. spectral values for (11) is reported.

Majapolene A, a Cytotoxic Peroxide, and Related Sesquiterpenes from the Red Alga Laurencia majuscula

1995 ◽  
Vol 58 (12) ◽  
pp. 1848-1860 ◽  
Author(s):  
Karen L. Erickson ◽  
John A. Beutler ◽  
Glenn N. Gray ◽  
John H. Cardellina ◽  
Michael R. Boyd
Keyword(s):  
Red Alga ◽  
Laurencia Majuscula

A new labile bromoterpenoid from the red alga laurencia majuscula: Dehydrochloroprepacifenol

Tetrahedron ◽  
1987 ◽  
Vol 43 (22) ◽  
pp. 5393-5399 ◽  
Author(s):  
Salvatore Caccamese ◽  
Anna Compagnini ◽  
Rosa Maria Toscano ◽  
Francesco Nicolo ◽  
Gervais Chapuis
Keyword(s):  
Red Alga ◽  
Laurencia Majuscula

Pacifenol from the Mediterranean Red Alga Laurencia majuscula

1986 ◽  
Vol 49 (1) ◽  
pp. 173-174 ◽  
Author(s):  
Salvatore Caccamese ◽  
Anna Compagnini ◽  
Rosa Maria Toscano
Keyword(s):  
Red Alga ◽  
The Mediterranean ◽  
Laurencia Majuscula

Delisea pulchra (cf. fimbriata) Revisited. The Structural Determination of Two New Metabolites From the Red Alga Delisea pulchra

1992 ◽  
Vol 45 (10) ◽  
pp. 1625 ◽  
Author(s):  
R Denys ◽  
JC Coll ◽  
BF Bowden
Keyword(s):  
Red Alga ◽  
Structural Determination ◽  
Delisea Pulchra ◽  
First Time ◽  
New Metabolites

Two new metabolites (1a) and (2a) have been isolated from the red alga Delisea pulchra . The previously reported metabolites (3)-(7) were also isolated, and the full n.m.r. characterization of (3), (4) and (6) is reported for the first time.

scholarly journals Cytotoxic effect of acetogenins and sesquiterpenes obtained from the Red alga Laurencia majuscula

2020 ◽  
Vol 19 (3) ◽  
pp. 583-586
Author(s):  
Hajer S. Alorfi ◽  
Mohamed A. Ghandourah ◽  
Adnan J. Turki
Keyword(s):  
Liver Cancer ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Cell Lines ◽  
Cytotoxic Effect ◽  
Red Alga ◽  
Hexane Extract ◽  
Hct 116 ◽  
Layer Chromatography ◽  
Laurencia Majuscula

Purpose: To evaluate the cytotoxicity of n-hexane extract and its metabolites obtained from the red alga, Laurencia majuscula, against three cancer cell lines HCT-116 (colon cancer), PC-3 (prostate cancer) and HepG2 (liver cancer) cells; and to identify the phytochemical compound(s) involved. Methods: Solvent extraction, thin layer chromatography, aluminum oxide column chromatography, and preparative thin layer chromatography (PTLC) were employed for isolating pure compounds from nhexane extract of Laurencia majuscula. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) measurements were used for structural elucidation of the compounds. The cytotoxicity of the nonpolar extract and isolated compounds were evaluated against HCT, PC-3, and HepG2 cells using MTT assay, relative to the standard cytotoxic drug (cisplatin). Results: Three sesquiterpenes (1, 2 and 8), and five acetogenins (3-7) were isolated from the n-hexane extract. The n-hexane extract showed higher potent cytotoxic effect than sesquiterpenes and the acetogenins (3-7). Conclusion: These results indicate that the n-hexane extract of Laurencia majuscula exerts significant cytotoxicity against HCT-116, PC-3 and HepG2 cell lines, thus suggesting that the plant extract may be effective chemotherapeutic agents for the management of colon, postrate and liver cancer. Keywords: Red Sea alga, Rhodomelaceae, Polyketides, Terpenes, Anticancer

Sign in / Sign up

Export Citation Format

Share Document