Diastereoselective synthesis of 3-[2-((N,N-dimethylamino)methyl)ferrocenyl]-4-(4-methoxyphenyl)hexan-3-ols, in racemic and optically active series, x-ray determination of their relative configuration

1994 ◽  
Vol 13 (1) ◽  
pp. 200-207 ◽  
Author(s):  
M. Gruselle ◽  
B. Malezieux ◽  
L. L. Troitskaya ◽  
V. I. Sokolov ◽  
L. M. Epstein ◽  
...  
Keyword(s):  
Optically Active ◽  
Diastereoselective Synthesis ◽  
Relative Configuration ◽  
X Ray

1,3-Dipolar [3+3] Cycloaddition of 1,4-Benzodiazepinone-Based Nitrones with α-Halohydroxamates for Diastereoselective Synthesis of Novel d-Edge Heterocycle-Fused 1,4-Benzodiazepinones

Synlett ◽  
2021 ◽  
Author(s):  
Hong-Wu Zhao ◽  
Heng Zhang ◽  
Lu-Yu Cai ◽  
Zhe Tang ◽  
Xiao-Zu Fan ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Reaction Mechanism ◽  
Single Crystal ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Diastereoselective Synthesis ◽  
Reaction Conditions ◽  
Relative Configuration ◽  
X Ray ◽  
Single Crystal Structure Analysis

Promoted by K2CO3 (2.0 equiv), the 1,3-dipolar [3+3] cycloaddition between 1, 4-benzodiazepinone-based nitrones and α-halohydroxamates processed smoothly under the mild reaction conditions and delivered structurally novel and complex cis or trans-configured d-edge-heterocycle-fused 1,4-benzodiazepinones in up to >99% isolated yield with >20:1 dr. The relative configuration of the title chemical entities was clearly identified with the use of X-ray single crystal structure analysis. The reaction mechanism was assumed to interpret the diastereoselective production of the obtained cis or trans-configured d-edge-heterocycle-fused 1, 4-benzodiazepinones.

Regio- and Diastereoselective Synthesis and X-ray Structure Determination of (+)-2-Deoxyoryzalexin S from (+)-Podocarpic Acid. Structural Nonidentity with Its Nominal Natural Isolated Enantiomer

2012 ◽  
Vol 75 (11) ◽  
pp. 1944-1950 ◽  
Author(s):  
Francesca Leonelli ◽  
Valentina Latini ◽  
Andrea Trombetta ◽  
Gabriele Bartoli ◽  
Francesca Ceccacci ◽  
...  
Keyword(s):  
Structure Determination ◽  
Diastereoselective Synthesis ◽  
X Ray

Sesquiterpenic lactones of the Inula caspica BLUME species

1990 ◽  
Vol 55 (6) ◽  
pp. 1568-1579 ◽  
Author(s):  
Sergazy M. Adekenov ◽  
Miloš Buděšínský ◽  
Metram A. Abdikalikov ◽  
Coblandy M. Turdybekov ◽  
David Šaman ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Cd Spectroscopy ◽  
X Ray Diffraction ◽  
Relative Configuration ◽  
X Ray

From Inula caspica BLUME (Compositae) were isolated 3β-hydroxy-2α-senecioyloxyisoalantolactone (I), whose structure was confirmed by X-ray diffraction and completed by determination of its absolute configuration, and britannin (II) whose relative configuration was determined by X-ray diffraction and absolute configuration by CD spectroscopy.

scholarly journals Determination of the relative configuration of tropinone and granatanone aldols by using TBDMS ethers

2012 ◽  
Vol 8 ◽  
pp. 1877-1883 ◽  
Author(s):  
Ryszard Lazny ◽  
Aneta Nodzewska ◽  
Katarzyna Sidorowicz ◽  
Przemyslaw Kalicki
Keyword(s):  
Coupling Constants ◽  
Side Chain ◽  
X Ray Diffraction ◽  
Relative Configuration ◽  
X Ray ◽  
Vicinal Coupling Constants ◽  
Nmr Data ◽  
And Shifts ◽  
Solventless Reaction

The relative configurations oftert-butyldimethylsilyl (TBDMS) ethers of all four diastereomers of the aldols of tropinone (8-methyl-8-azabicyclo[3.2.1]octan-3-one), as well as of granatanone (9-methyl-9-azabicyclo[3.3.1]nonan-3-one), were determined from NMR data, and from the observed interconversion of the diastereomers (exo,antitoendo,synandexo,syntoendo,anti). Theexoforms invert toendoisomers in the presence of silica gel. The relative configuration of a new isomer of tropinone aldol accessible synthetically through the direct solventless reaction of tropinone and benzaldehyde in the presence of water was determined asexo,synby comparison of NMR data of the aldol isomers, in particular vicinal coupling constants and shifts corresponding to the side-chain CH group, with data of related TBDMS derivatives and confirmed by single-crystal X-ray diffraction.

Lateral resolution of the electron microbeam analysis

1978 ◽  
Vol 36 (1) ◽  
pp. 542-543
Author(s):  
H.J. Dudek
Keyword(s):  
Quantitative Analysis ◽  
Depth Resolution ◽  
Lateral Resolution ◽  
Cylindrical Particle ◽  
Correction Procedure ◽  
X Ray ◽  
Element Concentrations ◽  
Microbeam Analysis ◽  
The Matrix

The chemical inhomogenities in modern materials such as fibers, phases and inclusions, often have diameters in the region of one micrometer. Using electron microbeam analysis for the determination of the element concentrations one has to know the smallest possible diameter of such regions for a given accuracy of the quantitative analysis.In th is paper the correction procedure for the quantitative electron microbeam analysis is extended to a spacial problem to determine the smallest possible measurements of a cylindrical particle P of high D (depth resolution) and diameter L (lateral resolution) embeded in a matrix M and which has to be analysed quantitative with the accuracy q. The mathematical accounts lead to the following form of the characteristic x-ray intens ity of the element i of a particle P embeded in the matrix M in relation to the intensity of a standard S

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