Rapid detection of earthworm small molecular peptide F-1 in cells by NU-1000- surface assisted laser desorption/ionization mass spectrometry

2021 ◽  
Author(s):  
Jingnan Wang
Keyword(s):  
Mass Spectrometry ◽  
Rapid Detection ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
In Cells

Lysine detection and quantification by laser desorption/ionization mass spectrometry on gold nanoparticle-enhanced target

2018 ◽  
Vol 10 (45) ◽  
pp. 5398-5405 ◽  
Author(s):  
Adrian Arendowski ◽  
Tomasz Ruman
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticle ◽  
Rapid Detection ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Spectrometry Method ◽  
Desorption Ionization ◽  
Detection And Quantification

Laser desorption/ionization mass spectrometry method on gold nanoparticle enhanced target (AuNPET) was used for rapid detection and quantification of lysine.

scholarly journals Detection of Metabolites in Cells through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

ACS Omega ◽  
2018 ◽  
Vol 3 (12) ◽  
pp. 17386-17391 ◽  
Author(s):  
Jinshun Cang ◽  
Li-Yi Chen ◽  
Yu-Syuan Lin ◽  
Huan-Tsung Chang
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
In Cells

scholarly journals Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 610
Author(s):  
Mariann Inga Van Meter ◽  
Salah M. Khan ◽  
Brynne V. Taulbee-Cotton ◽  
Nathan H. Dimmitt ◽  
Nathan D. Hubbard ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Active Pharmaceutical Ingredients ◽  
Laser Desorption Ionization ◽  
Over The Counter ◽  
Pharmaceutical Ingredients ◽  
Desorption Ionization

Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as agglomeration in tablets formulated with amorphous acetaminophen tablets. Multiple method advancements are presented to better resolve agglomeration caused by crystallinity in standard tablets. In this study, we also evaluate three “budget” over-the-counter headache medications (subsequently labeled as brands A, B, and C) for agglomeration of the three APIs in the formulation: Acetaminophen, aspirin, and caffeine. Electrospray laser desorption ionization mass spectrometry imaging (ELDI-MSI) was used to diagnose agglomeration in the tablets by creating molecular images and observing the spatial distributions of the APIs. Brand A had virtually no agglomeration or clustering of the active ingredients. Brand B had extensive clustering of aspirin and caffeine, but acetaminophen was observed in near equal abundance across the tablet. Brand C also had extensive clustering of aspirin and caffeine, and minor clustering of acetaminophen. These results show that agglomeration with active ingredients in over-the-counter tablets can be simultaneously detected using ELDI-MS imaging.

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