Alterations in Cellular Retinol Metabolism Contribute to Differential Retinoid Responsiveness in Normal Human Mammary Epithelial Cells Versus Breast Cancer Cells

2002 ◽  
Vol 72 (2) ◽  
pp. 95-105 ◽  
Author(s):  
Leslie J. Hayden ◽  
Michael A. Satre
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Normal Human ◽  
Retinol Metabolism

scholarly journals An oestrogen-dependent model of breast cancer created by transformation of normal human mammary epithelial cells

2007 ◽  
Vol 9 (3) ◽  
Author(s):  
Stephan Duss ◽  
Sylvie André ◽  
Anne-Laure Nicoulaz ◽  
Maryse Fiche ◽  
Hervé Bonnefoi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Normal Human ◽  
Dependent Model

Effect of the extracellular matrix on plasminogen activator isozyme activities of human mammary epithelial cells in culture

1983 ◽  
Vol 3 (6) ◽  
pp. 982-990
Author(s):  
N S Yang ◽  
C Park ◽  
C Longley ◽  
P Furmanski
Keyword(s):  
Extracellular Matrix ◽  
Epithelial Cells ◽  
Plasminogen Activator ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Collagen Gels ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Normal Human ◽  
Mcf 7

Multiple molecular forms of plasminogen activator were detected in normal human mammary epithelial cells in culture. Cells derived from (normal) breast mammoplasty specimens and grown on the surface of collagen gels exhibited three major classes of plasminogen activator isozymes (Mr = 100,000 [100K], 75,000 [75K], and 55,000 [55K]). The activity of the 100K and 75K isozymes was greatly reduced when the cells were grown on conventional tissue-culture-grade plastic surfaces. MCF-7, a human mammary carcinoma cell line, exhibited predominantly or exclusively the 55K isozyme, irrespective of the cell growth substratum. The activity of the 55K isozyme was more than twofold higher for MCF-7 cells grown on collagen gels than for cells grown on plastic. Progesterone, diethylstilbestrol, and estrogen stimulated the activity of the 55K isozyme of MCF-7 cells, but only when the cells were grown on a plastic surface. The plasminogen activator activities of the normal human mammary epithelial cells were not stimulated by these hormones, irrespective of the growth substratum. These results show that the expression of plasminogen activator isozymes by human mammary epithelial cells is subject to modulation by the extracellular matrix. Normal and malignant cells may differ in their responsiveness to these effects.

scholarly journals AhR ligands reactivate LINE-1 retrotransposon in triple-negative breast cancer cells MDA-MB-231 and non-tumorigenic mammary epithelial cells NMuMG

2020 ◽  
Vol 175 ◽  
pp. 113904
Author(s):  
Noelia Miret ◽  
C. Daniel Zappia ◽  
Gabriela Altamirano ◽  
Carolina Pontillo ◽  
Lorena Zárate ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial

17β‐hydroxysteroid dehydrogenases in normal human mammary epithelial cells and breast tissue

1999 ◽  
Vol 57 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Minna Miettinen ◽  
Mika Mustonen ◽  
Matti Poutanen ◽  
Veli Isomaa ◽  
Marie Wickman ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Breast Tissue ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Hydroxysteroid Dehydrogenases ◽  
Human Mammary Epithelial ◽  
Normal Human
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