Conformational Analysis of the Phosphorylated Epidermal Growth Factor Receptor
Keyword(s):
Phosphorylation-induced conformational changes have been well documented with different receptor tyrosine kinases. However, the susceptible epitopes and the tyrosine residue(s) involved in particular structural alteration mostly remain to be determined. Using a conformation-specific anti-peptide antibody, we have not only identified one such domain in the C-terminal tail of the EGF receptor but also identified the phosphate acceptor sites that are involved in the conformational change.
2016 ◽
Vol 292
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pp. 597-610
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2008 ◽
Vol 30
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pp. 1426-1447
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2003 ◽
Vol 289
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pp. 317-325
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1997 ◽
Vol 8
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pp. 1709-1721
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1996 ◽
Vol 93
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pp. 6252-6257
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