Activation of the respiratory burst by Pneumocystis carinii. Efficiency of different antibody isotypes, complement, lung surfactant protein D, and mannan-binding lectin

Apmis ◽  
2003 ◽  
Vol 111 (3) ◽  
pp. 405-415 ◽  
Author(s):  
ALEX L. LAURSEN ◽  
NIELS OBEL ◽  
UFFE HOLMSKOV ◽  
JENS C. JENSENIUS ◽  
EL MOUKHTAR ALIOUAT ◽  
...  
Keyword(s):  
Respiratory Burst ◽  
Lung Surfactant ◽  
Pneumocystis Carinii ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Antibody Isotypes ◽  
Lung Surfactant Protein ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Surfactant Protein D Increases Fusion of Mycobacterium tuberculosis- Containing Phagosomes with Lysosomes in Human Macrophages

2006 ◽  
Vol 74 (12) ◽  
pp. 7005-7009 ◽  
Author(s):  
J. Scott Ferguson ◽  
Jennifer L. Martin ◽  
Abul K. Azad ◽  
Travis R. McCarthy ◽  
Peter B. Kang ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Respiratory Burst ◽  
Lung Surfactant ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Intracellular Growth ◽  
Human Macrophages ◽  
Inhibition Of Growth ◽  
Lung Surfactant Protein ◽  
Bacterial Agglutination

ABSTRACT Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst.

scholarly journals Porcine Lung Surfactant Protein D: Complementary DNA Cloning, Chromosomal Localization, and Tissue Distribution

2000 ◽  
Vol 164 (3) ◽  
pp. 1442-1450 ◽  
Author(s):  
Martin van Eijk ◽  
Henk P. Haagsman ◽  
Thomas Skinner ◽  
Alan Archibold ◽  
Kenneth B. M. Reid ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Chromosomal Localization ◽  
Lung Surfactant ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Dna Cloning ◽  
Complementary Dna ◽  
Complementary Dna Cloning ◽  
Lung Surfactant Protein

Dynamic Strength of the Interaction between Lung Surfactant Protein D (SP-D) and Saccharide Ligands†

Biochemistry ◽  
2007 ◽  
Vol 46 (43) ◽  
pp. 12231-12237 ◽  
Author(s):  
Esben Thormann ◽  
Jakob K. Dreyer ◽  
Adam C. Simonsen ◽  
Per L. Hansen ◽  
Søren Hansen ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Dynamic Strength ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Lung Surfactant Protein

scholarly journals Mechanism of Interaction Between Lung Surfactant Protein-D and Influenza A Virus Hemagglutinin

2012 ◽  
Vol 102 (3) ◽  
pp. 63a
Author(s):  
Boon Chong Goh ◽  
Xueqing Zou ◽  
Michael J. Rynkiewicz ◽  
Barbara A. Seaton ◽  
Klaus J. Schulten
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Lung Surfactant ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Mechanism Of Interaction ◽  
Lung Surfactant Protein

scholarly journals Effect of Two Point Mutations in Lung Surfactant Protein-D on Enhancing its Inhibition Activity Against Influenza a Virus

2013 ◽  
Vol 104 (2) ◽  
pp. 556a
Author(s):  
Boon Chong Goh ◽  
Xueqing Zou ◽  
Michael J. Rynkiewicz ◽  
Barbara A. Seaton ◽  
Klaus Schulten
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Lung Surfactant ◽  
Point Mutations ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Inhibition Activity ◽  
Lung Surfactant Protein

scholarly journals Protective Role of Lung Surfactant Protein D in a Murine Model of Invasive Pulmonary Aspergillosis

2001 ◽  
Vol 69 (4) ◽  
pp. 2728-2731 ◽  
Author(s):  
Taruna Madan ◽  
Uday Kishore ◽  
Mamta Singh ◽  
Peter Strong ◽  
Ejaj M. Hussain ◽  
...  
Keyword(s):  
Murine Model ◽  
Lung Surfactant ◽  
Invasive Pulmonary Aspergillosis ◽  
Surfactant Protein ◽  
Protective Role ◽  
Surfactant Protein D ◽  
Protective Effects ◽  
Pulmonary Aspergillosis ◽  
Lung Surfactant Protein

ABSTRACT The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7 days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia.

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