Cyclin D1 expression in oral squamous cell carcinomas: clinicopathological relevance and correlation with p53 expression

2000 ◽  
Vol 29 (4) ◽  
pp. 167-172 ◽  
Author(s):  
King Y. Lam ◽  
Irene O. L. Ng ◽  
Anthony P. W. Yuen ◽  
Dora L. W. Kwong ◽  
William Wei
2002 ◽  
Vol 116 (05) ◽  
Author(s):  
Miguel Angel Gonzalez-Moles ◽  
Pablo Galindo ◽  
Jose Gutierrez ◽  
Alberto Rodriguez-Archilla ◽  
Isabel Ruiz-Avila ◽  
...  

Oral Oncology ◽  
2003 ◽  
Vol 39 (6) ◽  
pp. 610-618 ◽  
Author(s):  
Ryozo Miyamoto ◽  
Narikazu Uzawa ◽  
Shunya Nagaoka ◽  
Yasushi Hirata ◽  
Teruo Amagasa

Cancer ◽  
2007 ◽  
Vol 110 (10) ◽  
pp. 2230-2239 ◽  
Author(s):  
Narikazu Uzawa ◽  
Itaru Sonoda ◽  
Kunihiro Myo ◽  
Ken-Ichiro Takahashi ◽  
Ryozo Miyamoto ◽  
...  

2014 ◽  
Vol 7 (4) ◽  
pp. 1123-1127 ◽  
Author(s):  
YUICHI OHNISHI ◽  
MASAHIRO WATANABE ◽  
MASAHIRO WATO ◽  
AKIO TANAKA ◽  
KENJI KAKUDO ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Luís Silva Monteiro ◽  
Márcio Diniz-Freitas ◽  
Saman Warnakulasuriya ◽  
Tomás Garcia-Caballero ◽  
Jerónimo Forteza-Vila ◽  
...  

We analysed the expression of cyclins A2, B1, D1, and E1 by immunohistochemistry and numerical aberrations in CCND1 gene by fluorescence in situ hybridization technique in 67 primary oral squamous cell carcinomas (OSCC). Cyclin A2 expression was observed in 54 (83.1%) tumours, cyclin D1 in 58 (89.2%), cyclin B1 in 39 (60%), and cyclin E in 21 (32.8%). CCND1 region analysis revealed 26 (43.3%) tumours with the presence of numerical aberrations which were correlated with cyclin D1 high expression (Rho = 0.48; p<0.001). Twenty-nine (45.3%) tumours were classified as high proliferative tumours assessed by Ki-67 protein expression and correlated with tumours with high expression of cyclin A2 (Rho = 0.30; p=0.016) and cyclin B1 (Rho = 0.37; p=0.003). In multivariate analysis for an overall five-year survival (OS), we found an adverse independent prognostic value for cyclin A2 high expression (p=0.031) and for advanced tumour stage (p<0.001). Our results confirm that several cyclins are commonly expressed in OSCC. CCND1 gene is abnormal in more than one-third of the cases and is frequently associated with cyclin D1 high expression. Moreover, cyclin A2 high expression is an independent indicator of worse OS suggesting that this protein may serve as a reliable biological marker to identify high-risk subgroups with poor prognosis.


2000 ◽  
Vol 160 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Yuuji Nakahara ◽  
Satoru Shintani ◽  
Mariko Mihara ◽  
Akihisa Kiyota ◽  
Yoshiya Ueyama ◽  
...  

2015 ◽  
Vol 5 (9) ◽  
pp. 747-751 ◽  
Author(s):  
S Ghanghoria ◽  
A Ghanghoria ◽  
A Shukla

Background: Oral cancer is the sixth most common cancer in the world. P53 mutations are associated with the development of oral squamous cell carcinomas. This study is to determine the presence of p53 oncogene expression in cases of oral malignant, premalignant and benign lesions and to show association of p53 oncogene and lymph node enlargement in malignant lesion.Materials and Methods: Four to five micron-thick sections of formalin fixed, paraffin embedded biopsy material from various intra-oral sites of 50 patients were collected, in the series of 50 cases, 35 oral squamous cell carcinoma, 10 dysplastic lesions and 05 hyperplastic lesions were assessed for p53 expression. The tissue sections were immunohistochemically analyzed for the expression of p53 gene.Results: Out of 50; 22/35 (63%) cases of squamous cell carcinoma, 02/10 (20%) cases of dysplasia (20%), were positive for p53. Five hyperplastic lesions were negative for p53. The P53 protein was not identified in benign lesion.Conclusion: Results indicate that p53 over-expression is seen in oral squamous cell carcinomas. It is a significant marker of carcinogenesis and can be considered as an important marker for clinical evaluation, diagnosis as well as prognosis of disease.Journal of Pathology of Nepal (2015) Vol. 5, 747-751


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