Cyclin D1 expression in oral squamous cell carcinomas: clinicopathological relevance and correlation with p53 expression

2000 ◽  
Vol 29 (4) ◽  
pp. 167-172 ◽  
Author(s):  
King Y. Lam ◽  
Irene O. L. Ng ◽  
Anthony P. W. Yuen ◽  
Dora L. W. Kwong ◽  
William Wei
Keyword(s):  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Expression ◽  
Oral Squamous Cell Carcinomas

Significance of p53 expression in non-tumoral epithelium adjacent to oral squamous cell carcinomas

2002 ◽  
Vol 116 (05) ◽  
Author(s):  
Miguel Angel Gonzalez-Moles ◽  
Pablo Galindo ◽  
Jose Gutierrez ◽  
Alberto Rodriguez-Archilla ◽  
Isabel Ruiz-Avila ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Expression ◽  
Oral Squamous Cell Carcinomas

Prognostic significance of cyclin D1 amplification and overexpression in oral squamous cell carcinomas

Oral Oncology ◽  
2003 ◽  
Vol 39 (6) ◽  
pp. 610-618 ◽  
Author(s):  
Ryozo Miyamoto ◽  
Narikazu Uzawa ◽  
Shunya Nagaoka ◽  
Yasushi Hirata ◽  
Teruo Amagasa
Keyword(s):  
Cyclin D1 ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas

scholarly journals Fluorescence in situ hybridization for detecting genomic alterations of cyclin D1 and p16 in oral squamous cell carcinomas

Cancer ◽  
2007 ◽  
Vol 110 (10) ◽  
pp. 2230-2239 ◽  
Author(s):  
Narikazu Uzawa ◽  
Itaru Sonoda ◽  
Kunihiro Myo ◽  
Ken-Ichiro Takahashi ◽  
Ryozo Miyamoto ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Genomic Alterations ◽  
Oral Squamous Cell Carcinomas

Clinico-Pathological Correlation Of The Expression Of Cyclin D1 And Bcl-2 In Oral Squamous Cell Carcinomas -A Tissue Microarray Study

2012 ◽  
Vol 3 (2) ◽  
pp. 361-365
Author(s):  
Dr Monica Charlotte Solomon ◽  
◽  
Dr M S Vidyasagar Dr M S Vidyasagar ◽  
Dr Donald Fernandes ◽  
DrVasudeva Gudattu
Keyword(s):  
Cyclin D1 ◽  
Tissue Microarray ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Microarray Study ◽  
Pathological Correlation

scholarly journals Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas

2014 ◽  
Vol 7 (4) ◽  
pp. 1123-1127 ◽  
Author(s):  
YUICHI OHNISHI ◽  
MASAHIRO WATANABE ◽  
MASAHIRO WATO ◽  
AKIO TANAKA ◽  
KENJI KAKUDO ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Differentiation ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas

Expression of cyclin D1 is correlated with poor prognosis in patients with areaca quid chewing-related oral squamous cell carcinomas in Tiwan

2007 ◽  
Vol 28 (4) ◽  
pp. 165-169 ◽  
Author(s):  
Mark Yen-Ping Kuo ◽  
Chiao-Ying Lin ◽  
Liang-Jiunn Hahn ◽  
Shih-Jung Cheng ◽  
Chun-Pin Chiang
Keyword(s):  
Cyclin D1 ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas

scholarly journals Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Luís Silva Monteiro ◽  
Márcio Diniz-Freitas ◽  
Saman Warnakulasuriya ◽  
Tomás Garcia-Caballero ◽  
Jerónimo Forteza-Vila ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Cyclin B1 ◽  
Squamous Cell Carcinomas ◽  
High Expression ◽  
Hybridization Technique ◽  
Oral Squamous Cell Carcinomas ◽  
Numerical Aberrations ◽  
Cyclin A2

We analysed the expression of cyclins A2, B1, D1, and E1 by immunohistochemistry and numerical aberrations in CCND1 gene by fluorescence in situ hybridization technique in 67 primary oral squamous cell carcinomas (OSCC). Cyclin A2 expression was observed in 54 (83.1%) tumours, cyclin D1 in 58 (89.2%), cyclin B1 in 39 (60%), and cyclin E in 21 (32.8%). CCND1 region analysis revealed 26 (43.3%) tumours with the presence of numerical aberrations which were correlated with cyclin D1 high expression (Rho = 0.48; p<0.001). Twenty-nine (45.3%) tumours were classified as high proliferative tumours assessed by Ki-67 protein expression and correlated with tumours with high expression of cyclin A2 (Rho = 0.30; p=0.016) and cyclin B1 (Rho = 0.37; p=0.003). In multivariate analysis for an overall five-year survival (OS), we found an adverse independent prognostic value for cyclin A2 high expression (p=0.031) and for advanced tumour stage (p<0.001). Our results confirm that several cyclins are commonly expressed in OSCC. CCND1 gene is abnormal in more than one-third of the cases and is frequently associated with cyclin D1 high expression. Moreover, cyclin A2 high expression is an independent indicator of worse OS suggesting that this protein may serve as a reliable biological marker to identify high-risk subgroups with poor prognosis.

Alterations of Rb, p16INK4A and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas

2000 ◽  
Vol 160 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Yuuji Nakahara ◽  
Satoru Shintani ◽  
Mariko Mihara ◽  
Akihisa Kiyota ◽  
Yoshiya Ueyama ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas

scholarly journals p53 Expression in Oral cancer: A study of 50 cases

2015 ◽  
Vol 5 (9) ◽  
pp. 747-751 ◽  
Author(s):  
S Ghanghoria ◽  
A Ghanghoria ◽  
A Shukla
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
Squamous Cell Carcinomas ◽  
Biopsy Material ◽  
P53 Expression ◽  
Oral Squamous Cell Carcinomas ◽  
Formalin Fixed Paraffin Embedded

Background: Oral cancer is the sixth most common cancer in the world. P53 mutations are associated with the development of oral squamous cell carcinomas. This study is to determine the presence of p53 oncogene expression in cases of oral malignant, premalignant and benign lesions and to show association of p53 oncogene and lymph node enlargement in malignant lesion.Materials and Methods: Four to five micron-thick sections of formalin fixed, paraffin embedded biopsy material from various intra-oral sites of 50 patients were collected, in the series of 50 cases, 35 oral squamous cell carcinoma, 10 dysplastic lesions and 05 hyperplastic lesions were assessed for p53 expression. The tissue sections were immunohistochemically analyzed for the expression of p53 gene.Results: Out of 50; 22/35 (63%) cases of squamous cell carcinoma, 02/10 (20%) cases of dysplasia (20%), were positive for p53. Five hyperplastic lesions were negative for p53. The P53 protein was not identified in benign lesion.Conclusion: Results indicate that p53 over-expression is seen in oral squamous cell carcinomas. It is a significant marker of carcinogenesis and can be considered as an important marker for clinical evaluation, diagnosis as well as prognosis of disease.Journal of Pathology of Nepal (2015) Vol. 5, 747-751

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