This chapter highlights traumatic brain injury (TBI) and various health disparities within this population, particularly gaps related to patients from culturally diverse backgrounds. A review of three main health disparities is included, related to increased risk for sustaining a TBI, intervention barriers related to TBI, and long-term outcome after TBI. This chapter also evaluates how culture influences aspects of TBI intervention by exploring cultural considerations apparent in diverse populations. The chapter concludes with an examination of a case study based on an actual patient who sustained a TBI and details how his Native American culture impacted his healthcare choices and how his healthcare providers adapted intervention strategies given cultural influences unique to his clinical presentation.