Wellness and resilience promotion efforts are often an underutilized opportunity to address the mental health needs of children and youth. Organizations and individuals with state-level reach are ideally poised to develop and disseminate infrastructure, training, and resources to support wellness and resilience promotion efforts. This chapter highlights 8 key systems and practices that can inform and support such statewide efforts. Examples within Ohio, a recipient of 2 federal grants to support behavioral and mental health promotion, are used to illustrate the eight systems and practices. The chapter incorporates recommendations for others seeking to promote wellness and resilience in their respective contexts.