Multiple pregnancy after IVF: A retrospective study

ABSTRACT Objectives To determine the predictive factors for pregnancy after stimulated intrauterine insemination (IUI). Materials and methods A retrospective analysis of 136 patients undergoing 443 stimulated IUI cycles was done in an attempt to identify significant variables predictive of treatment success. The primary outcome measures were clinical pregnancy and live birth rates. Predictive factors evaluated were female age, duration of infertility, indication for IUI, number of preovulatory follicles, and postwash total motile fraction (TMF). Results The overall clinical pregnancy rate and live birth rate were 7.2% and 5.1 per cycle respectively. The mean number of IUI cycles per patient was 3.2, the miscarriage rate was 15%, and the multiple pregnancy rate was 3.1%. Among the predictive factors evaluated, female age (age > 37 years; p = 0.039), the duration of infertility (5.36 vs 6.71 years, p = 0.032), and the TMF (between 10 and 20 million, p = 0.003) significantly influenced the clinical pregnancy rate. Conclusion The clinical management of the selected infertile couple should be performed in an expedited manner taking into consideration the age of the woman, etiology, and duration of infertility and motile fraction of sperms. How to cite this article Patel AP, Patel MS, Shah SR, Jani SK. Predictive Factors for Pregnancy after Intrauterine Insemination: A Retrospective Study of Factors Affecting Outcome. J South Asian Feder Obst Gynae 2016;8(2):140-144.

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Safety and Efficacy of Higher Order Multifetal Pregnancy Reduction: A Single-Center Retrospective Study

American Journal of Perinatology Reports ◽

10.1055/s-0040-1715167 ◽

2020 ◽

Vol 10 (03) ◽

pp. e228-e233

Author(s):

Yan Liu ◽

Xie Tong Wang ◽

Hong Yan Li ◽

Hai Yan Hou ◽

Hong Wang ◽

...

Keyword(s):

Retrospective Study ◽

Birth Weight ◽

Pregnancy Loss ◽

Multiple Pregnancy ◽

Perinatal Outcomes ◽

Higher Order ◽

Sample Population ◽

Safety And Efficacy ◽

Multifetal Pregnancy ◽

Multifetal Pregnancy Reduction

Abstract Objective This research was aimed to study the safety and efficacy of higher order multifetal pregnancy reduction (MFPR). Study Design This was a retrospective study of patients from an academic maternity center between 2005 and 2015. We evaluated outcomes of 131 consecutive patients who underwent higher order MFPR (quadruplets and greater). MFPR was performed at 11 to 18 weeks of gestation in all cases. In total, 122 of 131 cases of higher order multiple pregnancy were reduced to twins. We discuss the perinatal outcomes of patients who underwent higher order MFPR, followed by a comparative analysis between the 122 cases of MFPR that were reduced to twins and 101 cases of nonreduced twin pregnancies. Results The study included 104 sets of quadruplets, 20 sets of quintuplets, 5 sets of sextuplets, 1 set of septuplets, and 1 set of octuplets. The perinatal outcomes of the 131 cases were as follows: pregnancy loss, preterm deliveries at 28 to 33 (+6/7) weeks, and preterm deliveries at 34 to 36 (+6/7) weeks occurred in 23.66, 9, and 37% of cases, respectively. The mean time of delivery was 36.56 ± 1.77 weeks, and mean birth weight was 2,409.90 ± 458.16 g, respectively. A total of 122 cases that were reduced to twins were compared with nonreduced twins. The pregnancy loss rate for reduced twins was significantly higher than that for nonreduced twins. The preterm labor rate, mean delivery week, mean birth weight, birth-weight discordance, incidence of gestational diabetes mellitus, and pregnancy-induced hypertension were not significantly different between the groups (p > 0.05). Conclusion Perinatal outcomes were significantly improved by reducing the number of fetuses in higher order multifetal pregnancies. This study involved a large, diverse sample population, and the results can be used as a reference while conducting prenatal counseling.

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A 3 year retrospective study of pregnancies complicated with placenta previa in a tertiary care centre

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20210003 ◽

2021 ◽

Author(s):

Vatsala Kamath ◽

Aparna C. Aravind ◽

Nishita Shettian

Keyword(s):

Retrospective Study ◽

Caesarean Section ◽

Pregnant Women ◽

Neonatal Intensive Care ◽

Placenta Previa ◽

Elective Caesarean Section ◽

Tertiary Care ◽

Multiple Pregnancy ◽

Age Group ◽

Tertiary Care Centre

Background: Placenta previa describes when a placenta is implanted partially or completely over the internal OS. About one third of the ante partum haemorrhage belongs to placenta previa. The incidence is increased beyond the age of 35 years, with high birth order pregnancies, prior caesarean deliveries and in multiple pregnancy. The aim of the study was to determine maternal and fetal outcome in pregnancies complicated with placenta previa.Methods: A 3 year retrospective study done in OBG department of A. J. Institute of Medical Sciences, Mangalore from January 2017- January 2020. All pregnant women who are diagnosed with placenta previa during regular antenatal care (ANC) follow up, at or after admission and during caesarean delivery are included in the study. Data were collected from the hospital records.Results: During the study period, there were 34 pregnant women with placenta previa. Maximum were in the age group of 31-35 years of age and 8.82 percentage were in the age group more than 35 years. Out of the study subjects,76.5 percentage were multigravidas and 50 percentage were giving history of prior one caesarean section. 29.4 percentage of study subjects had true placenta previa and 85.2 percentage underwent elective caesarean section. There were significantly higher number of babies required neonatal intensive care unit (NICU) admissions.Conclusions: An increase in the incidence of women with advanced maternal age, multiparity, prior caesarean deliveries contributes to a rise in the number of pregnancies complicated with placenta previa.

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The effects of different post-thawed culture periods on clinical outcomes in frozen embryo transfer cycle: a retrospective study

10.22541/au.161901490.03685505/v1 ◽

2021 ◽

Author(s):

Yuhu Li ◽

Xuexiang Cai ◽

Bo Ma ◽

Ning LI ◽

liuguang zhang

Keyword(s):

Retrospective Study ◽

Pregnancy Rate ◽

Clinical Outcomes ◽

Embryo Transfer ◽

Live Birth ◽

Birth Rate ◽

Low Birthweight ◽

Multiple Pregnancy ◽

Implantation Rate ◽

Live Birth Rate

Objective To evaluate the effects of different post-thawed culture periods on the clinical outcomes Design A retrospective study. Setting Two IVF centers. Population Women undergoing first cleavage-stage embryo transfer in frozen-thawed cycles. Methods 9832 FET cycles were divided into three groups according to female age: < 35, 35-39 and > 39 years, and two groups depending on post-thawed culture period: short and long culture groups. The long culture group divided into three groups depending on blastomere growth number: ≤ 2, one ≤ 2 and the other > 2, and > 2 groups. Main Outcome Measures Implantation rate (IR), clinical pregnancy rate (CPR), multiple pregnancy rate (MPR), live birth rate (LBR) and neonatal characteristics. Results Long post-thawed culture caused a significant increase in the IR, CPR, MPR and LBR (P/CI = 0.002/1.034-1.162, 0.027/1.011-1.194, 0.028/1.014-1.255 and 0.001/1.054-1.245 respectively), and blastomere growth number had a significant effect on IR, CPR, MPR and LBR (P = 0.000, 0.000, 0.000 and 0.000 respectively). No significant differences were present in neonatal characteristics between the two post-thawed culture groups. Singleton group had a higher average gestational age and birthweight as well as a lower cesarean section rate, preterm labor rate and low birthweight rate. Conclusions Long post-thawed culture was associated with higher IR, CPR, MPR and LBR, and transferring a well-developed embryo after long post-thawed culture might be a viable embryo transfer strategy to decrease MPR while maintaining CPR and LBR. Funding None Keywords Post-thawed culture, blastomere growth, neonatal characteristics, live birth rate.

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