Primary motor cortex stimulation affects visual guidance and attention systems

2014 ◽  
Author(s):  
Thomas Taylor ◽  
Mickie Vanhoy ◽  
Jingjing Wang ◽  
Shanshan Haung
Keyword(s):  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Motor Cortex Stimulation ◽  
Visual Guidance ◽  
Attention Systems

scholarly journals Distinct behavioral response of primary motor cortex stimulation in itch and pain after burn injury

2019 ◽  
Vol 690 ◽  
pp. 89-94 ◽  
Author(s):  
Aurore Thibaut ◽  
Emily A. Ohrtman ◽  
Leon Morales-Quezada ◽  
Laura C. Simko ◽  
Colleen M. Ryan ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Behavioral Response ◽  
Primary Motor Cortex ◽  
Burn Injury ◽  
Motor Cortex Stimulation

Is Closed-Loop, Time-Locked Primary Motor Cortex Stimulation an Ideal Target for Improving Movements in Neurological Disorders?

2016 ◽  
Vol 31 (9) ◽  
pp. 1341-1341 ◽  
Author(s):  
Matt J.N. Brown ◽  
Antonella Macerollo ◽  
James M. Kilner ◽  
Robert Chen
Keyword(s):  
Motor Cortex ◽  
Neurological Disorders ◽  
Closed Loop ◽  
Primary Motor Cortex ◽  
Motor Cortex Stimulation

scholarly journals A systematic review of the proposed mechanisms underpinning pain relief by primary motor cortex stimulation in animals

2020 ◽  
Vol 719 ◽  
pp. 134489 ◽  
Author(s):  
Dylan Henssen ◽  
Esmay Giesen ◽  
Maudy van der Heiden ◽  
Mijke Kerperien ◽  
Sibylle Lange ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pain Relief ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Motor Cortex Stimulation

scholarly journals The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>

2019 ◽  
Vol 09 (03) ◽  
pp. 138-152
Author(s):  
Priscila Medeiros ◽  
Sylmara Esther Negrini-Ferrari ◽  
Ana Carolina Medeiros ◽  
Lais Leite Ferreira ◽  
Josie Resende Torres da Silva ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Motor Cortex ◽  
Rattus Norvegicus ◽  
Primary Motor Cortex ◽  
Motor Cortex Stimulation ◽  
Peripheral Neuropathic Pain ◽  
Cold Allodynia ◽  
Pain Condition ◽  
Neuropathic Pain Condition

scholarly journals Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down

2020 ◽  
Author(s):  
Jaisan Islam ◽  
Elina KC ◽  
Byeong Ho Oh ◽  
Soochong Kim ◽  
Sang-hwan Hyun ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Motor Cortex ◽  
Trigeminal Neuralgia ◽  
Trigeminal Ganglion ◽  
Primary Motor Cortex ◽  
Infraorbital Nerve ◽  
Motor Cortex Stimulation ◽  
Trigeminal Neuropathic Pain ◽  
Optogenetic Stimulation ◽  
Stimulation Of

Abstract Background Previous studies have reported that electrical stimulation of the motor cortex is effective in reducing trigeminal neuropathic pain; however, the effects of optical motor cortex stimulation remain unclear. Objective The present study aimed to investigate whether optical stimulation of the primary motor cortex can modulate chronic neuropathic pain in rats with infraorbital nerve constriction injury. Methods Animals were randomly divided into a trigeminal neuralgia group, a sham group, and a control group. Trigeminal neuropathic pain was generated via constriction of the infraorbital nerve and animals were treated via selective inhibition of calcitonin gene-related peptide in the trigeminal ganglion. We assessed alterations in behavioral responses in the pre-stimulation, stimulation, and post-stimulation conditions. In vivo extracellular recordings were obtained from the ventral posteromedial nucleus of the thalamus, and viral and α-CGRP expression were investigated in the primary motor cortex and trigeminal ganglion, respectively. Results We found that optogenetic stimulation significantly improved pain behaviors in the trigeminal neuralgia animals and it provided more significant improvement with inhibited α-CGRP state than active α-CGRP state. Electrophysiological recordings revealed decreases in abnormal thalamic firing during the stimulation-on condition. Conclusion Our findings suggest that optical motor cortex stimulation can alleviate pain behaviors in a rat model of trigeminal neuropathic pain. Transmission of trigeminal pain signals can be modulated via knock-down of α-CGRP and optical motor cortex stimulation.

scholarly journals Optogenetic Stimulation of The Motor Cortex Alleviates Neuropathic Pain in Rats of Infraorbital Nerve Injury With/Without CGRP Knock-Down

2020 ◽  
Author(s):  
Jaisan Islam ◽  
Elina KC ◽  
Byeong Ho Oh ◽  
Soochong Kim ◽  
Sang-hwan Hyun ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Motor Cortex ◽  
Trigeminal Neuralgia ◽  
Trigeminal Ganglion ◽  
Primary Motor Cortex ◽  
Infraorbital Nerve ◽  
Motor Cortex Stimulation ◽  
Trigeminal Neuropathic Pain ◽  
Optogenetic Stimulation ◽  
Stimulation Of

Abstract Background: Previous studies have reported that electrical stimulation of the motor cortex is effective in reducing trigeminal neuropathic pain; however, the effects of optical motor cortex stimulation remain unclear. Objective: The present study aimed to investigate whether optical stimulation of the primary motor cortex can modulate chronic neuropathic pain in rats with infraorbital nerve constriction injury.Methods: Animals were randomly divided into a trigeminal neuralgia group, a sham group, and a control group. Trigeminal neuropathic pain was generated via constriction of the infraorbital nerve and animals were treated via selective inhibition of calcitonin gene-related peptide in the trigeminal ganglion. We assessed alterations in behavioral responses in the pre-stimulation, stimulation, and post-stimulation conditions. In vivo extracellular recordings were obtained from the ventral posteromedial nucleus of the thalamus, and viral and α-CGRP expression were investigated in the primary motor cortex and trigeminal ganglion, respectively.Results: We found that optogenetic stimulation significantly improved pain behaviors in the trigeminal neuralgia animals and it provided more significant improvement with inhibited α-CGRP state than active α-CGRP state. Electrophysiological recordings revealed decreases in abnormal thalamic firing during the stimulation-on condition.Conclusion: Our findings suggest that optical motor cortex stimulation can alleviate pain behaviors in a rat model of trigeminal neuropathic pain. Transmission of trigeminal pain signals can be modulated via knock-down of α-CGRP and optical motor cortex stimulation.

scholarly journals Functional connectivity of the primary motor cortex stimulation in patients with central post-stroke pain

PAIN RESEARCH ◽  
2015 ◽  
Vol 30 (3) ◽  
pp. 173-176 ◽  
Author(s):  
Koichi Hosomi ◽  
Takeshi Shimizu ◽  
Tomoyuki Maruo ◽  
Yoshiyuki Watanabe ◽  
Koo Hui Ming ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Motor Cortex Stimulation ◽  
Post Stroke

scholarly journals Motor cortex stimulation: mild transient benefit in a primate model of Parkinson disease

2007 ◽  
Vol 106 (4) ◽  
pp. 695-700 ◽  
Author(s):  
Alex K. Wu ◽  
Kevin W. McCairn ◽  
Gabriel Zada ◽  
Tiffany Wu ◽  
Robert S. Turner
Keyword(s):  
Motor Cortex ◽  
Parkinson Disease ◽  
Video Analysis ◽  
Therapeutic Efficacy ◽  
Primary Motor Cortex ◽  
Motor Cortex Stimulation ◽  
Motor Threshold ◽  
Primate Model ◽  
Consistent Change ◽  
Food Retrieval

Object The authors sought to examine the therapeutic efficacy of motor cortex stimulation (MCS) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)–treated macaques and to characterize therapeutic differences with varying modes, frequencies, and durations of stimulation. Methods Motor cortex stimulation was delivered at currents below motor threshold and at frequencies between 5 and 150 Hz through epidural electrodes over the primary motor cortex. The animals were studied during and without MCS using video analysis, activity logging, and food retrieval tasks. Animals were examined using two different stimulation protocols. The first protocol consisted of 1 hour of MCS therapy daily. The second protocol exposed the animal to continuous MCS for more than 24 hours with at least 2 weeks between MCS treatments. Conclusions Daily MCS yielded no consistent change in symptoms, but MCS at 2-week intervals resulted in significant increases in activity. Effects of biweekly MCS disappeared, however, within 24 hours of the onset of continuous MCS. In this study, MCS only temporarily reduced the severity of MPTP-induced parkinsonism.

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