Evaluating the claim that high confidence implies high accuracy in eyewitness identification.

Author(s):  
Andrew M. Smith ◽  
Laura Smalarz ◽  
Ryan Ditchfield ◽  
Nydia T. Ayala
2021 ◽  
Vol 17 (12) ◽  
pp. e1009675
Author(s):  
Sarah A. Robinson ◽  
Matthew I. J. Raybould ◽  
Constantin Schneider ◽  
Wing Ki Wong ◽  
Claire Marks ◽  
...  

Identifying the epitope of an antibody is a key step in understanding its function and its potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with similar epitope complementarity, however, antibodies from markedly different lineages but with similar structures can engage the same epitope. We describe a novel computational method for epitope profiling based on structural modelling and clustering. Using the method, we demonstrate that sequence dissimilar but functionally similar antibodies can be found across the Coronavirus Antibody Database, with high accuracy (92% of antibodies in multiple-occupancy structural clusters bind to consistent domains). Our approach functionally links antibodies with distinct genetic lineages, species origins, and coronavirus specificities. This indicates greater convergence exists in the immune responses to coronaviruses than is suggested by sequence-based approaches. Our results show that applying structural analytics to large class-specific antibody databases will enable high confidence structure-function relationships to be drawn, yielding new opportunities to identify functional convergence hitherto missed by sequence-only analysis.


2017 ◽  
Vol 18 (1) ◽  
pp. 10-65 ◽  
Author(s):  
John T. Wixted ◽  
Gary L. Wells

Summary The U.S. legal system increasingly accepts the idea that the confidence expressed by an eyewitness who identified a suspect from a lineup provides little information as to the accuracy of that identification. There was a time when this pessimistic assessment was entirely reasonable because of the questionable eyewitness-identification procedures that police commonly employed. However, after more than 30 years of eyewitness-identification research, our understanding of how to properly conduct a lineup has evolved considerably, and the time seems ripe to ask how eyewitness confidence informs accuracy under more pristine testing conditions (e.g., initial, uncontaminated memory tests using fair lineups, with no lineup administrator influence, and with an immediate confidence statement). Under those conditions, mock-crime studies and police department field studies have consistently shown that, for adults, (a) confidence and accuracy are strongly related and (b) high-confidence suspect identifications are remarkably accurate. However, when certain non-pristine testing conditions prevail (e.g., when unfair lineups are used), the accuracy of even a high-confidence suspect ID is seriously compromised. Unfortunately, some jurisdictions have not yet made reforms that would create pristine testing conditions and, hence, our conclusions about the reliability of high-confidence identifications cannot yet be applied to those jurisdictions. However, understanding the information value of eyewitness confidence under pristine testing conditions can help the criminal justice system to simultaneously achieve both of its main objectives: to exonerate the innocent (by better appreciating that initial, low-confidence suspect identifications are error prone) and to convict the guilty (by better appreciating that initial, high-confidence suspect identifications are surprisingly accurate under proper testing conditions).


2017 ◽  
Author(s):  
Carolyn Semmler ◽  
John Cameron Dunn ◽  
Laura Mickes ◽  
John Wixted

Estimator variables are factors that can affect the accuracy of eyewitness identifications but that are outside of the control of the criminal justice system. Examples include (1) the duration of exposure to the perpetrator, (2) the passage of time between the crime and the identification (retention interval), (3) the distance between the witness and the perpetrator at the time of the crime. Suboptimal estimator variables (e.g., long distance) have long been thought to reduce the reliability of eyewitness identifications (IDs), but recent evidence suggests that this is not true of IDs made with high confidence and may or may not be true of IDs made with lower confidence. The evidence suggests that while suboptimal estimator variables decrease discriminability (i.e., the ability to distinguish innocent from guilty suspects), they do not decrease the reliability of IDs made with high confidence. Such findings are inconsistent with the longstanding “optimality hypothesis” and therefore require a new theoretical framework. Here, we propose that a signal-detection-based likelihood ratio account – which has long been a mainstay of basic theories of recognition memory – naturally accounts for these findings.


2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 11036-11036
Author(s):  
S. Rosenwald ◽  
H. Gibori ◽  
S. Gilad ◽  
L. Cohen ◽  
I. Leizerman ◽  
...  

11036 Background: Hundreds of thousands of patients are diagnosed each year with metastatic cancer. For ∼10% of these, the tumor primary site is never identified, and they are defined as Cancer of Unknown Primary (CUP). Identification of tumor tissue-of- origin has significant therapeutic implications and presents a major diagnostic challenge. In previous work we showed that by combining expression profiles of tissue-specific microRNAs with a biologically-motivated classification scheme, tumor tissue-of-origin can be identified with high accuracy. Here we describe the development of this approach into a practical diagnostic assay. Methods: We developed protocols for extraction of high-quality RNA that retain the microRNA fraction from FFPE archival tissue samples. Proprietary, highly specific qRT-PCR was used to profile microRNA expression levels in hundreds of samples. Results: A training set of nearly 400 primary and metastatic tumors samples with known primary sites, representing 25 different tumor types, was used to define a standardized diagnostics assay (miRview mets). The assay uses a qRT-PCR protocol to measure a panel of 48 microRNA biomarkers. The assay was validated on a test set of nearly 200 primary and metastatic tumors whose primary sites were blinded. The classification protocol identifies either a single, high-confidence origin or two possible low-confidence predictions. Overall, correct primary site was identified for 83% of the tumors. For 70% of the cases a single high-confidence prediction was made; these cases had a higher accuracy: 90% of the primary sites predicted with high confidence were accurately identified. Conclusions: Previous studies highlighted the tissue-specificity of microRNA expression. We developed this potential into a diagnostic assay that identifies tumor origins with high accuracy. This assay provides an important new tool for diagnosing tumor tissue origin. [Table: see text]


Author(s):  
M. Nishigaki ◽  
S. Katagiri ◽  
H. Kimura ◽  
B. Tadano

The high voltage electron microscope has many advantageous features in comparison with the ordinary electron microscope. They are a higher penetrating efficiency of the electron, low chromatic aberration, high accuracy of the selected area diffraction and so on. Thus, the high voltage electron microscope becomes an indispensable instrument for the metallurgical, polymer and biological specimen studies. The application of the instrument involves today not only basic research but routine survey in the various fields. Particularly for the latter purpose, the performance, maintenance and reliability of the microscope should be same as those of commercial ones. The authors completed a 500 kV electron microscope in 1964 and a 1,000 kV one in 1966 taking these points into consideration. The construction of our 1,000 kV electron microscope is described below.


1983 ◽  
Vol 38 (5) ◽  
pp. 550-563 ◽  
Author(s):  
Michael McCloskey ◽  
Howard E. Egeth

2000 ◽  
Author(s):  
Steven E. Clark ◽  
Jennifer L. Tunnicliff ◽  
Allison Abbe ◽  
Dominique Hysmith

2012 ◽  
Author(s):  
Steven E. Clark ◽  
Molly B. Moreland ◽  
Scott D. Gronlund

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