Further Evidence relating to the Mode of Action of Nicotine in the Central Nervous System

Nature ◽  
1967 ◽  
Vol 214 (5092) ◽  
pp. 977-979 ◽  
Author(s):  
A. K. ARMITAGE ◽  
G. H. HALL
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mode Of Action ◽  
The Central Nervous System

SITE AND MODE OF ACTION OF CLONIDINE IN THE CENTRAL NERVOUS SYSTEM

2009 ◽  
Vol 201 (S602) ◽  
pp. 106-109
Author(s):  
Ilari Paakkari ◽  
Heikki Karppanen ◽  
Pirkko Paakkari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mode Of Action ◽  
The Central Nervous System

The Mode of Action of the Corpus Cardiacum on the Hind Gut in Periplaneta Americana

1962 ◽  
Vol 39 (3) ◽  
pp. 319-324
Author(s):  
K. G. DAVEY
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Mode Of Action ◽  
Periplaneta Americana ◽  
Corpus Cardiacum ◽  
Corpora Cardiaca ◽  
The Central Nervous System ◽  
Hind Gut

1. Addition of a homogenate of corpora cardiaca to the fluid bathing an isolated hind gut of Periplaneta produces an increase in tonus, amplitude, frequency and co-ordination of contractions. 2. The corpus cardiacum acts by stimulating cells in the upper colon to release an indolalkylamine. 3. This amine acts on the mucles through a peripheral nervous system which can function in isolation from the central nervous system.

scholarly journals Effect of Barbiturates on Synaptic Currents

1976 ◽  
Vol 4 (3) ◽  
pp. 199-202 ◽  
Author(s):  
T. A. Torda ◽  
P. W. Gage
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuromuscular Junction ◽  
Synaptic Transmission ◽  
Time Constant ◽  
Mode Of Action ◽  
Synaptic Currents ◽  
End Plate ◽  
The Central Nervous System ◽  
Central Synapses

Thiopentone and pentobarbitone reduce the time constant of decay of miniature end-plate currents when applied in anaesthetic concentrations to the neuromuscular junction. Such an effect at central synapses would lead to failure of synaptic transmission in the central nervous system and may reflect a common mode of action of many anaesthetic drugs.

Relation of blood pH and CO2 to central stimulatory effects of saline on dogs

1963 ◽  
Vol 205 (4) ◽  
pp. 723-726
Author(s):  
Olle Höök ◽  
Morton Rubinstein ◽  
Robert B. Aird
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Normal Saline ◽  
Mode Of Action ◽  
Neck Muscles ◽  
Excitatory Effect ◽  
Muscular Tone ◽  
Blood Ph ◽  
The Central Nervous System

Normal saline (0.9% NaCl, pH 5.85) infused intracisternally in dogs has a general excitatory effect on the central nervous system, producing increased rate and depth of respiration and increased muscular tone with muscle discharges, especially from facial, cranial, and neck muscles. This excitatory effect correlated most closely with changes in systemic pCO2. being enhanced when the arterial pCO2 was decreased and being depressed when the arterial pCO2 was increased. This excitatory effect also can be depressed or abolished by relatively small concentrations of CaCl2. Mode of action is discussed.

scholarly journals Wilhelm Siegmund Feldberg, C. B. E. 19 November 1900—23 October 1993

1997 ◽  
Vol 43 ◽  
pp. 145-170 ◽  
Author(s):  
G. W. Bisset ◽  
T. V. P. Bliss
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Synaptic Transmission ◽  
20Th Century ◽  
Mode Of Action ◽  
Experimental Approach ◽  
Chemical Nature ◽  
Working Life ◽  
The Central Nervous System ◽  
The Brain

Wilhelm Siegmund Feldberg, one of the greatest neuropharmacologists of the 20th century, was born in Hamburg on 19 November 1900. During a working life of 65 years, he published over 350 papers. His early work in Berlin on the pharmacology of histamine and acetylcholine was followed in the 1930s by his fundamental work with Dale, which finally established the chemical nature of synaptic transmission in the peripheral nervous system. In later years he turned to the central nervous system, introducing a new and widely adopted experimental approach to elucidate the site and mode of action of drugs in the brain.

Further Observations on the Influence of Toxins on the Central Nervous System

1914 ◽  
Vol 60 (249) ◽  
pp. 184-191
Author(s):  
D. Orr ◽  
R. G. Rows
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Mode Of Action ◽  
Peripheral Nerves ◽  
The Central Nervous System

For some years, we have been engaged in an investigation into the mode of action of toxins upon the central nervous system, and up to the present time have devoted our attention exclusively to the question of the upward passage of bacterial poisons along the sheaths of peripheral nerves to the spinal cord and brain. Experiment has shown us that toxins readily travel upwards in the perineural lymphatics, in which they induce an inflammation whose phenomena vary with the intensity of the irritant; and that this is continued without interruption to the central nervous system, granted that the toxins gain that level. Continuity of extension is, therefore, an important feature of lymphogenous inflammation, and is as constant in the central as in the peripheral nervous system.

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