H–2 region product as determinant in immune cytolysis of syngeneic tumour cells by anti-MSV T lymphocytes

Nature ◽  
1976 ◽  
Vol 260 (5553) ◽  
pp. 707-709 ◽  
Author(s):  
ELISABETH GOMARD ◽  
VERONIQUE DUPREZ ◽  
YVETTE HENIN ◽  
JEAN PAUL LEVY
Keyword(s):  
T Lymphocytes ◽  
Tumour Cells ◽  
Region Product ◽  
Immune Cytolysis

4-Hydroperoxyclophosphamide: a model for eliminating residual human tumour cells and T-lymphocytes from the bone marrow graft

1982 ◽  
Vol 52 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Martin Körbling ◽  
Allan D. Hess ◽  
Peter J. Tutschka ◽  
Herbert Kaizer ◽  
Michael O. Colvin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Lymphocytes ◽  
Tumour Cells ◽  
Human Tumour ◽  
Marrow Graft ◽  
Human Tumour Cells ◽  
Bone Marrow Graft

▾ Aldesleukin for metastatic renal cell carcinoma?

1993 ◽  
Vol 31 (8) ◽  
pp. 29-30
Keyword(s):  
Renal Cell Carcinoma ◽  
T Lymphocytes ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Interleukin 2 ◽  
Protein Product ◽  
Tumour Cells ◽  
Lak Cells

Interleukin 2 (IL2), a protein product of T lymphocytes, promotes the development of lymphokine-activated killer (LAK) cells, which can lyse tumour cells.1 Aldesleukin (Proleukin – EuroCetus), a recombinant human IL2, has recently been marketed for the treatment of patients with metastatic renal cell carcinoma.

Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes

1999 ◽  
Vol 47 (5) ◽  
pp. 278-286 ◽  
Author(s):  
Nicole M. Haynes ◽  
Mark J. Smyth ◽  
Michael H. Kershaw ◽  
Joseph A. Trapani ◽  
Phillip K. Darcy
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Fas Ligand ◽  
Tumour Cells

CD8+ T lymphocytes isolated from renal cancer patients recognize tumour cells through an HLA- and TCR/CD3-independent pathway

2006 ◽  
Vol 56 (7) ◽  
pp. 1065-1076 ◽  
Author(s):  
Ilaria Lionello ◽  
Patrizia Mangia ◽  
Luca Gattinoni ◽  
Daniela Pende ◽  
Arcadi Cippone ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cancer Patients ◽  
Renal Cancer ◽  
Tumour Cells ◽  
Cd8 T Lymphocytes

Induction of human cytotoxic T lymphocytes that preferentially recognise tumour cells bearing a conformational p53 mutant

2000 ◽  
Vol 49 (8) ◽  
pp. 417-425 ◽  
Author(s):  
Stephanie E. B. McArdle ◽  
Robert C. Rees ◽  
Kevin A. Mulcahy ◽  
Jeanine Saba ◽  
Catherine A. McIntyre ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Tumour Cells

scholarly journals Characterization of antigen-presenting properties of tumour cells using virus-specific cytotoxic T lymphocytes

2000 ◽  
Vol 82 (8) ◽  
pp. 1474-1479 ◽  
Author(s):  
D C J Spierings ◽  
E Agsteribbe ◽  
J Wilschut ◽  
V Langrish
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Tumour Cells ◽  
Antigen Presenting

Chimeric T-cell receptors: highly specific tools to target cytotoxic T-lymphocytes to tumour cells

1997 ◽  
Vol 23 (2) ◽  
pp. 97-112 ◽  
Author(s):  
H. Abken ◽  
A. Hombach ◽  
C. Heuser ◽  
R. Sircar ◽  
C. Pohl ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
T Cell Receptors ◽  
Tumour Cells ◽  
Cell Receptors

scholarly journals Cloned cytotoxic T lymphocytes that recognize an I-A region product in the context of a class I antigen.

1986 ◽  
Vol 163 (4) ◽  
pp. 972-980 ◽  
Author(s):  
N Shinohara ◽  
J A Bluestone ◽  
D H Sachs
Keyword(s):  
T Lymphocytes ◽  
Cell Surface ◽  
Gene Product ◽  
Cytotoxic T Lymphocytes ◽  
Class Ii ◽  
Class I ◽  
Target Antigen ◽  
Ia Antigens ◽  
Region Product ◽  
Class Ii Antigen

Cloned CTLs QM3 and QM7 isolated from a bulk CTL line B10.QBR anti-B10.MBR recognized a combination of the H-2Kb molecule and an I-Ak subregion gene product. Such a combinatorial specificity was revealed by complementation of the target antigen in F1 animals between two negative parental strains carrying H-2Kb and I-Ak, respectively. We confirmed the involvement of the H-2Kb molecule by blocking killing with anti-Kb mAb and failure of certain mutant H-2Kb genes to complement with I-Ak to generate the determinant in F1 animals. Although the nature of the I-Ak subregion gene product is not definitive, there was a correlation between the expression of Ia antigens on the cell surface and susceptibility of the cells to lysis by these CTLs, suggesting that it is the classical I-Ak class II antigen.

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