Vitamin D metabolism and function

Nature ◽  
1980 ◽  
Vol 283 (5742) ◽  
pp. 115-115
Author(s):  
R. H. Wasserman
Keyword(s):  
Vitamin D ◽  
Vitamin D Metabolism ◽  
And Function

Regulation of vitamin D metabolism and function.

1973 ◽  
Vol 53 (2) ◽  
pp. 327-372 ◽  
Author(s):  
J L Omdahl ◽  
H F DeLuca
Keyword(s):  
Vitamin D ◽  
Vitamin D Metabolism ◽  
And Function

scholarly journals Vitamin D metabolism, sex hormones, and male reproductive function

Reproduction ◽  
2012 ◽  
Vol 144 (2) ◽  
pp. 135-152 ◽  
Author(s):  
Martin Blomberg Jensen
Keyword(s):  
Vitamin D ◽  
Association Studies ◽  
Reproductive Function ◽  
Hormone Production ◽  
Vitamin D Metabolism ◽  
Mediated Effects ◽  
Male Reproductive Function ◽  
Expression Studies ◽  
Metabolizing Enzyme ◽  
And Function

The spectrum of vitamin D (VD)-mediated effects has expanded in recent years, and VD is now recognized as a versatile signaling molecule rather than being solely a regulator of bone health and calcium homeostasis. One of the recently identified target areas of VD is male reproductive function. The VD receptor (VDR) and the VD metabolizing enzyme expression studies documented the presence of this system in the testes, mature spermatozoa, and ejaculatory tract, suggesting that both systemic and local VD metabolism may influence male reproductive function. However, it is still debated which cell is the main VD target in the testis and to what extent VD is important for sex hormone production and function of spermatozoa. This review summarizes descriptive studies on testicular VD metabolism and spatial distribution of VDR and the VD metabolizing enzymes in the mammalian testes and discusses mechanistic and association studies conducted in animals and humans. The reviewed evidence suggests some effects of VD on estrogen and testosterone biosynthesis and implicates involvement of both systemic and local VD metabolism in the regulation of male fertility potential.

scholarly journals Low Plasma 25-Hydroxyvitamin D and Risk of Tobacco-Related Cancer

2013 ◽  
Vol 59 (5) ◽  
pp. 771-780 ◽  
Author(s):  
Shoaib Afzal ◽  
Stig E Bojesen ◽  
Børge G Nordestgaard
Keyword(s):  
Vitamin D ◽  
Tobacco Smoke ◽  
Population Based ◽  
Lower Plasma ◽  
Vitamin D Metabolism ◽  
Hydroxyvitamin D ◽  
Hazard Ratios ◽  
25 Hydroxyvitamin D ◽  
And Function

BACKGROUND Tobacco smoke chemicals may influence vitamin D metabolism and function, and conversely vitamin D may modify the carcinogenicity of tobacco smoke chemicals. We tested the hypothesis that lower plasma 25-hydroxyvitamin D [25(OH)D] is associated with a higher risk of tobacco-related cancer in the general population. METHODS A prospective population-based cohort of 9791 individuals from the Copenhagen City Heart Study who were free of cancer at baseline was followed from 1981–1983 until December 2008 with 100% complete follow-up. RESULTS During up to 28 years of follow-up, 1081 participants developed a tobacco-related cancer and 1506 developed other cancers. Decreasing 25(OH)D concentrations, subdivided by clinical categories or by seasonally adjusted percentile categories, were associated with increasing cumulative incidence of tobacco-related cancer (log-rank trend P = 2 × 10−6 and P = 5 × 10−9). Multivariable adjusted hazard ratios of tobacco-related cancer were 1.75 (95% CI, 1.33–2.30) for 25(OH)D <5 vs ≥20 ng/mL, and 2.07 (1.63–2.62) for ≤5th vs >66th percentile. Also, multivariable adjusted hazard ratios for a 50% reduction in 25(OH)D were 1.20 (1.13–1.28) for any tobacco-related cancer, 1.19 (95% CI, 1.09–1.31) for lung cancer, 1.44 (1.19–1.73) for head and neck cancer, 1.28 (1.06–1.54) for bladder cancer, 1.34 (1.04–1.73) for kidney cancer, and 0.95 (0.89–1.01) for other cancers. CONCLUSIONS Lower plasma 25(OH)D was associated with higher risk of tobacco-related cancers, but not with risk of other cancers.

Vitamin D Metabolism and Function

1978 ◽  
Vol 138 (Suppl_5) ◽  
pp. 836 ◽  
Author(s):  
Hector F. DeLuca
Keyword(s):  
Vitamin D ◽  
Vitamin D Metabolism ◽  
And Function

scholarly journals Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Daniel D Bikle
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Phosphate Homeostasis ◽  
Vitamin D Metabolism ◽  
Metabolizing Enzymes ◽  
Clinical Level ◽  
New Information ◽  
A Cell ◽  
And Function

Abstract The interest in vitamin D continues unabated with thousands of publications contributing to a vast and growing literature each year. It is widely recognized that the vitamin D receptor (VDR) and the enzymes that metabolize vitamin D are found in many cells, not just those involved with calcium and phosphate homeostasis. In this mini review I have focused primarily on recent studies that provide new insights into vitamin D metabolism, mechanisms of action, and clinical applications. In particular, I examine how mutations in vitamin D metabolizing enzymes—and new information on their regulation—links vitamin D metabolism into areas such as metabolism and diseases outside that of the musculoskeletal system. New information regarding the mechanisms governing the function of the VDR elucidates how this molecule can be so multifunctional in a cell-specific fashion. Clinically, the difficulty in determining vitamin D sufficiency for all groups is addressed, including a discussion of whether the standard measure of vitamin D sufficiency, total 25OHD (25 hydroxyvitamin) levels, may not be the best measure—at least by itself. Finally, several recent large clinical trials exploring the role of vitamin D supplementation in nonskeletal diseases are briefly reviewed, with an eye toward what questions they answered and what new questions they raised.

Persistent HCV-infection and liver damage change vitamin-D-metabolism

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
A Amanzada ◽  
A Lindhorst ◽  
F Moriconi ◽  
M Blaschke ◽  
T Suermann ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Damage ◽  
Hcv Infection ◽  
Vitamin D Metabolism
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