Artificial transmembrane ion channels from self-assembling peptide nanotubes

Nature ◽  
1994 ◽  
Vol 369 (6478) ◽  
pp. 301-304 ◽  
Author(s):  
M. Reza Ghadiri ◽  
Juan R. Granja ◽  
Lukas K. Buehler
Keyword(s):  
Ion Channels ◽  
Peptide Nanotubes ◽  
Self Assembling

Self-Assembling Cyclic β3-Peptide Nanotubes as Artificial Transmembrane Ion Channels

1998 ◽  
Vol 120 (4) ◽  
pp. 651-656 ◽  
Author(s):  
Thomas D. Clark ◽  
Lukas K. Buehler ◽  
M. Reza Ghadiri
Keyword(s):  
Ion Channels ◽  
Peptide Nanotubes ◽  
Self Assembling

scholarly journals Nanoscale assemblies and their biomedical applications

2013 ◽  
Vol 10 (80) ◽  
pp. 20120740 ◽  
Author(s):  
Tais A. P. F. Doll ◽  
Senthilkumar Raman ◽  
Raja Dey ◽  
Peter Burkhard
Keyword(s):  
Biomedical Applications ◽  
Vaccine Development ◽  
Building Blocks ◽  
Eukaryotic Cells ◽  
Peptide Nanotubes ◽  
Protein Cages ◽  
Bacterial Microcompartments ◽  
Self Assembling ◽  
Development Section ◽  
Characteristic Features

Nanoscale assemblies are a unique class of materials, which can be synthesized from inorganic, polymeric or biological building blocks. The multitude of applications of this class of materials ranges from solar and electrical to uses in food, cosmetics and medicine. In this review, we initially highlight characteristic features of polymeric nanoscale assemblies as well as those built from biological units (lipids, nucleic acids and proteins). We give special consideration to protein nanoassemblies found in nature such as ferritin protein cages, bacterial microcompartments and vaults found in eukaryotic cells and designed protein nanoassemblies, such as peptide nanofibres and peptide nanotubes. Next, we focus on biomedical applications of these nanoscale assemblies, such as cell targeting, drug delivery, bioimaging and vaccine development. In the vaccine development section, we report in more detail the use of virus-like particles and self-assembling polypeptide nanoparticles as new vaccine delivery platforms.

scholarly journals Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate (BSH) delivery system for boron neutron capture t (BNCT)

2020 ◽  
Author(s):  
Hiroyuki Michiue ◽  
Mizuki Kitamatsu ◽  
Asami Fukunaga ◽  
Nobushige Tsuboi ◽  
Atsushi Fujimura ◽  
...  
Keyword(s):  
Delivery System ◽  
Neutron Capture ◽  
Peptide Nanotubes ◽  
Self Assembling ◽  
Boron Neutron Capture

Self-assembling peptide nanotubes

Nano Today ◽  
2008 ◽  
Vol 3 (3-4) ◽  
pp. 22-30 ◽  
Author(s):  
Shane Scanlon ◽  
Amalia Aggeli
Keyword(s):  
Peptide Nanotubes ◽  
Self Assembling

Designer cyclopeptides for self-assembled tubular structures

2000 ◽  
Vol 72 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Darshan Ranganathan ◽  
C. Lakshmi ◽  
V. Haridas ◽  
M. Gopikumar
Keyword(s):  
Design Strategy ◽  
Single Step ◽  
Simple Design ◽  
Tubular Structures ◽  
Peptide Nanotubes ◽  
X Ray ◽  
X Ray Crystallography ◽  
Self Assembling ◽  
Direct Condensation ◽  
Hydrogen Bonded

A simple design strategy for a facile and direct entry into hydrogen-bonded peptide nanotubes is delineated with polymethylene-bridged cystine-based macrocycles. The key feature of the design is the placement of a pair of self-complementary hydrogen-bonding (NH–CO or NH–CO–NH) groups at almost opposite poles of the ring. A large variety of cyclobisamides and bisureas prepared in a single step by direct condensation of commercially available 1,ω-alkane dicarbonyl dichloride or diisocyanate with either cystine diOMe or its extended bispeptide were examined by X-ray crystallography and shown to possess an inherent property of self-assembling into hydrogen-bonded, open-ended, hollow tubular structures. The totally hydrophobic interior of the cyclobisamide tubes creates a micro environment capable of solubilizing highly lipophilic substances in water. The cyclic bisurea tubes are demonstrated to act as excellent receptors for selective binding to 1,ω-alkane dicarboxylates. The scope of the design is extended to the creation of tubular structures by stacking of rings through aromatic π-π interactions.

scholarly journals Design of Self-Assembling Peptide Nanotubes with Delocalized Electronic States

Small ◽  
2006 ◽  
Vol 2 (1) ◽  
pp. 99-102 ◽  
Author(s):  
Nurit Ashkenasy ◽  
W. Seth Horne ◽  
M. Reza Ghadiri
Keyword(s):  
Electronic States ◽  
Peptide Nanotubes ◽  
Self Assembling

scholarly journals Self-Assembling Peptide Nanotubes with Antiviral Activity against Hepatitis C Virus

2011 ◽  
Vol 18 (11) ◽  
pp. 1453-1462 ◽  
Author(s):  
Ana Montero ◽  
Pablo Gastaminza ◽  
Mansun Law ◽  
Guofeng Cheng ◽  
Francis V. Chisari ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Peptide Nanotubes ◽  
Self Assembling

Self-Assembling Peptide Nanotubes

1999 ◽  
pp. 61-66 ◽  
Author(s):  
Juan R. Granja ◽  
M. Reza Ghadiri
Keyword(s):  
Peptide Nanotubes ◽  
Self Assembling
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